Vozan 20mg Tab

VOZAN 20MG TABLET

VOZAN 20MG TABLET is a medication primarily used for the treatment of various acid-related gastrointestinal disorders. It is manufactured by Eris Oaknet Healthcare Pvt Ltd (also referred to as Eris Life Sciences Ltd).

Composition

• Active Ingredient: Each tablet contains 20mg of Vonoprazan.

Uses

VOZAN 20MG TABLET is a potassium-competitive acid blocker (P-CAB) that works by reducing the amount of acid produced in the stomach. It is prescribed for:

• Stomach Ulcers: Treatment and prevention of gastric and duodenal ulcers.
• Gastroesophageal Reflux Disease (GERD): Management of GERD, including its symptoms like heartburn and acid regurgitation.
• Erosive Esophagitis: Healing of erosive esophagitis and relief of associated heartburn.
• Helicobacter pylori Eradication: Used in combination with specific antibiotics (e.g., amoxicillin and clarithromycin or metronidazole) to eliminate H. pylori bacteria, which can cause stomach ulcers.
• Ulcer Recurrence Prevention: To prevent the recurrence of gastric or duodenal ulcers, especially in individuals taking low-dose aspirin or NSAIDs.

Dosage and Administration

• VOZAN 20MG TABLET should be swallowed whole with plenty of water, and can be taken with or without food.
• Typical Adult Dosages (may vary based on condition and doctor's advice):
  • Erosive Esophagitis: 20mg once daily for 8 weeks; for maintenance, 10mg once daily for up to 6 months.
  • Stomach Ulcers: 20mg once daily for 8 weeks.
  • Duodenal Ulcers: 20mg once daily for 6 weeks.
  • H. pylori Eradication: 20mg twice daily for 7-14 days, in combination with prescribed antibiotics.
• Dosage adjustments may be necessary for patients with renal or hepatic impairment.

Side Effects

• Common Side Effects: Diarrhea, stomach pain, nausea, indigestion, bloating, high blood pressure, headache, changes in taste sense, urinary tract infection, stomach inflammation, and nasopharyngitis.
• Serious Side Effects (less common but require medical attention): Clostridioides difficile-associated infection, pseudomembranous colitis, benign gastric polyps (with prolonged use), increased risk of osteoporosis-related fractures (with long-term or high doses), hepatic function abnormalities, hypomagnesemia (with prolonged use), and severe skin reactions like Stevens-Johnson syndrome.

Precautions

• Allergies: Do not take if allergic to Vonoprazan or any other ingredients.
• Drug Interactions: Avoid concomitant use with Rilpivirine, Atazanavir, and Nelfinavir (anti-HIV medications). It may also reduce the effectiveness of medicines requiring an acidic stomach environment (e.g., Iron salts, certain antifungals).
• Pregnancy and Breastfeeding: Limited safety information is available; consult a doctor before use.
• Driving: May cause dizziness; avoid driving or operating machinery until you know how it affects you.
• Organ Impairment: Use with caution in patients with kidney or liver disease.
• Long-term Use: Prolonged use may lead to Vitamin B12 deficiency, hypomagnesemia, and fundic gland polyps.
• Other: May mask symptoms of gastric malignancy. Avoid alcohol consumption. Not recommended for children under 18 years.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep out of the sight and reach of children.
• Store below 30°C.

What is VOZAN 20MG Tablet used for?

VOZAN 20MG Tablet is primarily used for the treatment and prevention of sores in the lining of the stomach or intestine, also known as gastric and duodenal ulcers. It is also prescribed to heal damage to the esophagus caused by excess stomach acid (erosive esophagitis) and to alleviate associated heartburn. Additionally, when prescribed with other antibiotics, it helps to eliminate Helicobacter pylori bacteria, which can lead to stomach ulcers and other gastrointestinal issues. It can also be used for the management of Gastro-oesophageal reflux disease (GERD).

How does VOZAN 20MG Tablet work?

VOZAN 20MG Tablet contains vonoprazan, which is a potassium-competitive acid blocker (P-CAB). It works by inhibiting a specific enzyme in the stomach cells called H+/K+-ATPase, also known as the proton pump. This enzyme is responsible for the final step of acid production in the stomach. By blocking this pump, vonoprazan effectively reduces the amount of stomach acid, which helps to heal ulcers and alleviate acid-related symptoms. Unlike traditional proton pump inhibitors (PPIs), vonoprazan does not require stomach acid to function and binds to the proton pumps temporarily, allowing for faster and more consistent control of gastric pH.

What is the usual dosage for VOZAN 20MG Tablet?

The usual adult dosage for VOZAN 20MG Tablet varies depending on the condition being treated. For gastric ulcers, it is typically 20mg administered orally once daily for 8 weeks. For duodenal ulcers, it's 20mg once daily for 6 weeks. For reflux esophagitis, the usual dose is 20mg once daily for 4 weeks, with a possible extension if needed. For the eradication of Helicobacter pylori, it's often used as part of a triple therapy regimen with antibiotics, typically 20mg twice daily for 7 days. It is important to follow your doctor's exact instructions and not to alter the prescribed dosage.

What are the possible side effects of VOZAN 20MG Tablet?

Common side effects of VOZAN 20MG Tablet may include diarrhea, stomach pain, nausea, high blood pressure, indigestion, and bloating. Other reported side effects include headache, changes in taste, vaginal yeast infection, and cold-like symptoms. If you experience any severe or persistent side effects, it is essential to consult your healthcare provider.

Is VOZAN 20MG Tablet safe during pregnancy or breastfeeding?

There is limited safety information available on the use of VOZAN 20MG Tablet in pregnant women. It is not known whether vonoprazan can harm an unborn baby. Therefore, it should only be used during pregnancy if the potential benefits justify the potential risks, and you should consult your doctor. Regarding breastfeeding, it is advised not to breastfeed your baby while on this medicine as it may pass into breast milk. Always discuss potential risks and benefits with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can VOZAN 20MG Tablet be taken with other medications?

VOZAN 20MG Tablet can interact with certain other medications. It may reduce the effectiveness of medicines such as Rilpivirine, Nelfinavir, and Atazanavir (used to treat HIV/AIDS). It can also affect medicines that require a more acidic environment in the stomach to work effectively, such as iron salts, Erlotinib, Dasatinib, Nilotinib, Mycophenolate mofetil, and Ketoconazole/Itraconazole. It's crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking or might take to avoid possible interactions.

What precautions should be taken while using VOZAN 20MG Tablet?

Before taking VOZAN 20MG Tablet, inform your doctor if you have any liver or kidney problems, low blood magnesium, calcium, or potassium levels, or if you are taking a diuretic. This medicine may cause dizziness, so you should not drive or operate machinery until you know how it affects you. Avoid consuming alcohol, as it can reduce the effectiveness of the tablet and delay the healing of ulcers. Also, avoid spicy, acidic, or fatty foods that can trigger acid reflux, and avoid lying down immediately after eating.

What happens if a dose of VOZAN 20MG Tablet is missed?

If you miss a dose of VOZAN 20MG Tablet and it is within 12 hours of your usual time (for erosive esophagitis and heartburn), take it as soon as you remember. If it is more than 12 hours after the missed dose, skip the missed dose and take your next dose at the regular time. For H. pylori infection treatment, if a dose is missed within 4 hours, take it as soon as possible; otherwise, skip the missed dose. Never double the next dose to compensate for a missed one.

How should VOZAN 20MG Tablet be stored?

VOZAN 20MG Tablet should be stored in a cool and dry place, away from sunlight. Keep it out of the sight and reach of children and pets. It is recommended to store it at room temperature, generally below 30°C.