Midorise 5 Mg Tablet (10 Tab)

MIDORISE 5 MG TABLET

MIDORISE 5 MG TABLET, manufactured by TORRENT PHARMACEUTICALS LTD., is a medication primarily used to manage low blood pressure.

Composition MIDORISE 5 MG TABLET contains 5 mg of Midodrine Hydrochloride as its active ingredient.

Uses This medicine is an antihypotensive, primarily prescribed for the treatment of low blood pressure (hypotension), especially idiopathic postural hypotension or orthostatic hypotension. This condition involves a sudden drop in blood pressure when moving from a sitting or lying position to standing, leading to symptoms such as dizziness, lightheadedness, fainting, blurred vision, and weakness. Midodrine works by stimulating alpha-1 adrenergic receptors in the blood vessels, causing them to constrict, which in turn increases peripheral vascular resistance and raises blood pressure.

Dosage and Administration MIDORISE 5 MG TABLET is taken orally with water, and the tablet should be swallowed whole without crushing or chewing. It is typically administered two to three times daily during daytime hours (e.g., morning, midday, and late afternoon before 6 PM), with doses spaced at least three hours apart. The last daily dose should be taken before an evening meal and at least four hours before bedtime. It should not be taken if you plan to lie down for an extended period. The exact dosage and duration of treatment are determined by a healthcare professional based on the patient's condition and response. Regular monitoring of blood pressure is crucial during treatment.

Side Effects Common side effects may include supine hypertension (increased blood pressure when lying down), headache, nausea, rash, difficulty or frequent urination, urinary retention, flushing (a sense of warmth), goosebumps or chills, tingling sensations, stomach pain, dry mouth, dizziness, drowsiness, and leg cramps. More serious, though less common, side effects can include chest pain, palpitations, blurred vision, reflex bradycardia (slow heart rate), and arrhythmias (irregular heart rhythms). Seek immediate medical attention if allergic reactions such as hives, swelling of the face, lips, tongue, or throat occur.

Precautions MIDORISE 5 MG TABLET is contraindicated in individuals with severe heart disease (including heart failure or high blood pressure), overactive thyroid, adrenal gland tumors (phaeochromocytoma), severe kidney disease, urinary retention, narrow-angle glaucoma, or known hypersensitivity to midodrine. Caution is advised in patients with liver problems, a history of stroke, prostate disorders, or certain eye problems related to diabetes. Pregnant or breastfeeding individuals should consult their doctor before use, and the medicine should be discontinued immediately if pregnancy is confirmed during treatment. This medication is not recommended for children under 18 years of age. Avoid consuming alcohol as it may worsen dizziness and drowsiness. Do not discontinue the medication abruptly. Exercise caution when driving or operating heavy machinery if experiencing dizziness or lightheadedness. Inform your doctor about all other medications, especially thyroid hormones, tricyclic antidepressants, MAO inhibitors, vasoconstrictors, sympathomimetic agents, and digitalis preparations, as interactions can occur.

Storage Store MIDORISE 5 MG TABLET at room temperature, ideally between 20°C to 25°C (68°F to 77°F), or below 30°C. Keep the medicine in its original packaging, away from light, moisture, and heat, and out of the sight and reach of children and pets.

What is Midorise 5 MG Tablet used for?

Midorise 5 MG Tablet is primarily used to treat low blood pressure (hypotension), specifically symptomatic orthostatic hypotension. This condition causes symptoms such as dizziness, lightheadedness, fainting, blurred vision, and weakness, particularly when transitioning from a lying or sitting position to standing. It is prescribed when daily activities are severely affected and other treatments, like support stockings, have not been adequate.

How does Midorise 5 MG Tablet work?

Midorise 5 MG Tablet contains the active ingredient midodrine hydrochloride, which is a prodrug. Once in the body, it is converted into its active form, desglymidodrine. This active metabolite acts as an alpha-1 adrenergic agonist, stimulating alpha-1 receptors found in blood vessels. This stimulation causes the blood vessels to constrict or narrow, which increases peripheral vascular resistance and, consequently, raises blood pressure.

What is the usual dosage for Midorise 5 MG Tablet?

The usual dosage for adults is typically 2.5 mg to 10 mg, taken two to three times a day during waking hours. Doses should be spaced at least 3-4 hours apart. It is crucial to take the last daily dose before an evening meal and at least 4 hours before bedtime to prevent a significant increase in blood pressure when lying down (supine hypertension). Your doctor will determine the exact dose and duration based on your medical condition and response.

What are the possible side effects of Midorise 5 MG Tablet?

Common side effects can include supine hypertension (high blood pressure while lying down), headache, nausea, rash, difficulty or frequent urination, urinary retention, flushing (a sensation of warmth), and piloerection (goosebumps or tingling sensation of the scalp). Less common but more serious side effects may include chest pain, palpitations, blurred vision, reflex bradycardia (abnormally slow heart rate), and irregular heart rhythms (arrhythmias). If any side effects persist or worsen, you should consult your doctor.

Is Midorise 5 MG Tablet safe during pregnancy or breastfeeding?

Midorise 5 MG Tablet is generally not recommended for use during pregnancy and is contraindicated. If you become pregnant while on this medication, you should discontinue it immediately and consult your doctor. Similarly, it is probably unsafe during breastfeeding as there is limited human data, but it suggests the drug may pass into breast milk and could potentially harm the baby.

Can Midorise 5 MG Tablet be taken with other medications?

Midorise 5 MG Tablet can interact with various medications. It's important to inform your doctor about all prescription, over-the-counter, and herbal products you are taking. Interactions can occur with other blood pressure medications (e.g., reserpine, guanethidine, alpha-receptor blockers), antihistamines, thyroid hormones (like thyroxine), tricyclic antidepressants, MAO-inhibitors, vasoconstrictors (e.g., epinephrine), sympathomimetic agents (e.g., ephedrine), digitalis preparations, fludrocortisone acetate, perphenazine, amiodarone, and metoclopramide.

What precautions should be taken while on Midorise 5 MG Tablet?

Regular monitoring of your blood pressure, both when lying down and standing, is crucial due to the risk of supine hypertension. You should promptly report any symptoms of supine hypertension, such as palpitations, headaches, or blurred vision, to your doctor. The medication should not be taken if you plan to lie down for an extended period or within 4 hours of bedtime. Midorise 5 MG Tablet is contraindicated in individuals with severe heart disease, uncontrolled high blood pressure, severe kidney disease, pheochromocytoma, overactive thyroid, enlarged prostate with urinary retention, narrow-angle glaucoma, or certain types of diabetic eye disease. Alcohol consumption should be avoided as it may worsen dizziness and drowsiness.

What happens if a dose of Midorise 5 MG Tablet is missed?

If you miss a dose of Midorise 5 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Midorise 5 MG Tablet be stored?

Midorise 5 MG Tablet should be stored at room temperature, typically between 15-30°C (68-77°F). It should be kept in its original packaging, protected from excessive heat, moisture, and direct light. Always keep this medicine out of the reach and sight of children and pets.