Moximac (10 Tab)

MOXIMAC (10 TAB) by MACLEODS PHARMACEUTICALS LTD.

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Name

• Brand Name: Moximac Tablet,
• Common Name: Moxifloxacin (as Moxifloxacin Hydrochloride),,

Composition

• Each tablet contains Moxifloxacin 400mg,,. Moxifloxacin belongs to the fluoroquinolone class of antibiotics.

Uses Moximac Tablet is an antibiotic primarily used to treat a wide range of bacterial infections. It works by inhibiting bacterial DNA replication, thus killing the bacteria and preventing their reproduction,,,. Specific conditions it is prescribed for include:

• Respiratory Infections: Acute bacterial sinusitis, acute bacterial worsening of chronic bronchitis, and community-acquired pneumonia,,,,.
• Urinary Tract Infections (UTIs),,,.
• Skin and Soft Tissue Infections,,,,.
• Prostatitis.
• Complicated Intra-abdominal Infections (often in combination with other medicines like metronidazole).
• Pelvic Inflammatory Disease,.
• Tuberculosis (as a second-line antimycobacterial drug when first-line options are not suitable).

Dosage and Administration

• The typical dosage for adults is one 400mg tablet once daily,,,.
• It can be taken with or without food,,,.
• Swallow the tablet whole with water; do not crush, chew, or break it,.
• It is crucial to follow the prescribed dosage and duration, and to complete the full course of treatment even if symptoms improve, to ensure complete eradication of the infection and prevent antibiotic resistance,,. Do not take a double dose to compensate for a missed one,.

Side Effects Common Side Effects:

• Nausea, vomiting, stomach pain, diarrhea,,,,.
• Headache, dizziness,,,,.
• Loss of appetite, indigestion,.
• Insomnia (difficulty sleeping),.
• Change in taste,.
• Increased transaminase levels (liver enzymes),,. Serious Side Effects (less common but require medical attention):
• Tendon rupture or tendinitis,,.
• Irregular heartbeat (QT prolongation),,.
• Severe allergic reactions.
• Liver problems,.
• Muscle weakness (especially in patients with myasthenia gravis),.
• Peripheral neuropathy (pain, burning, tingling, numbness, or weakness),.
• Photosensitivity (increased skin sensitivity to sunlight),,.

Precautions

• Contraindications: Do not take Moximac if you are allergic to Moxifloxacin or any other quinolone antibiotics,,. It is not recommended during pregnancy or breastfeeding without consulting a doctor,,,, and should not be used in individuals under 18 years of age,.
• Pre-existing Conditions: Inform your doctor if you have heart problems (especially irregular heartbeat, QT prolongation, or uncorrected hypokalemia), liver disease, kidney disease, a history of tendon disorders related to quinolones, myasthenia gravis, seizure disorders, or diabetes,,,,.
• Drug Interactions: Moximac can interact with medicines that prolong the QT interval (e.g., certain antiarrhythmics, tricyclic antidepressants, macrolides), sucralfate, zinc, iron supplements, charcoal, blood thinners (like warfarin), and blood sugar-lowering medications (like glibenclamide),,,. Medicines that lower potassium levels should also be avoided.
• Warnings: Avoid alcohol consumption as it may increase dizziness,. Moximac may cause dizziness and affect driving ability, so operate vehicles or machinery only when alert,,,. Avoid excessive exposure to sunlight, as it can make your skin more sensitive,,.

Storage

• Store in a cool and dry place, away from direct sunlight,,,.
• Keep out of sight and reach of children,.
• Store at room temperature, typically below 25°C or 30°C,,,.

MOXIMAC (Moxifloxacin Hydrochloride 400mg Film Coated Tablets) is an antibiotic manufactured by Macleods Pharmaceuticals Ltd., primarily used to treat various bacterial infections.

What is MOXIMAC used for?

MOXIMAC is an antibiotic used to treat a wide range of bacterial infections in adults. These include infections of the urinary tract, nose, throat, skin and soft tissues, and lungs (pneumonia, acute bronchitis, acute bacterial sinusitis). It is also indicated for infections of the female upper genital tract and complicated intra-abdominal infections, often in combination with other medications. It is also used as a second-line antimycobacterial drug for tuberculosis when first-line drugs are not appropriate.

How does MOXIMAC work?

MOXIMAC contains Moxifloxacin, a fluoroquinolone antibiotic. It works by inhibiting two essential bacterial enzymes: DNA gyrase (topoisomerase II) and topoisomerase IV. These enzymes are crucial for bacterial DNA replication, transcription, and repair. By blocking their activity, Moxifloxacin disrupts the bacteria's ability to multiply and repair themselves, ultimately killing the bacteria and stopping the infection.

What is the usual dosage for MOXIMAC?

For adults, adolescents, and children weighing at least 30 kg and above 15 years of age, the recommended dose is one 400 mg tablet once daily. It can be taken with or without food, preferably at a fixed time each day. The tablet should be swallowed whole with sufficient liquid.

What are the possible side effects of MOXIMAC?

Common side effects may include headache, dizziness, nausea, vomiting, stomach pain, diarrhea, increased transaminase levels in the blood, constipation, heartburn, insomnia, and decreased potassium levels. Serious but rare side effects can include tendon rupture, irregular heartbeat (QT prolongation), severe allergic reactions, and liver problems. If you experience severe side effects or persistent symptoms, contact your doctor.

Is MOXIMAC safe during pregnancy or breastfeeding?

MOXIMAC is generally considered unsafe during pregnancy as its safety in human pregnancy has not been investigated, and animal studies have shown reproductive toxicity. It should only be used if the benefit outweighs the risks and no alternative treatments are available. The use of moxifloxacin during breastfeeding is contraindicated, as small amounts pass into breast milk and it has been shown to cause joint lesions in immature animals.

Can MOXIMAC be taken with other medications?

MOXIMAC can interact with several medications. It should not be taken with drugs that prolong the QT interval (e.g., certain antiarrhythmics, antipsychotics) or medications that can reduce potassium levels (e.g., diuretics, laxatives). Antacids, sucralfate, and supplements containing iron, aluminum, magnesium, or zinc can reduce MOXIMAC's absorption, so MOXIMAC should be taken 2 to 4 hours before or 4 to 6 hours after these agents. It may also enhance the effect of blood thinners like warfarin and could lower the effect of blood sugar-lowering medications. Always inform your doctor about all medicines, herbal preparations, and supplements you are taking.

What precautions should be taken while using MOXIMAC?

Avoid excessive sunlight exposure as MOXIMAC can increase photosensitivity. Stay hydrated and complete the full course of treatment to prevent bacterial resistance. Caution is advised in patients with heart conditions, a history of tendon disorders, myasthenia gravis, or CNS disorders like epilepsy, as MOXIMAC can increase the risk of seizures. Patients with diabetes should monitor blood glucose carefully. Avoid alcohol consumption as it may increase side effects like dizziness.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember, provided it was due fewer than 12 hours ago. If more than 12 hours have passed, or if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

How should MOXIMAC be stored?

MOXIMAC tablets should be stored below 30°C (or below 25°C) in a dry place, protected from light, and in the original container. Keep it out of reach of children and pets.