Drofem Tablet

DROFEM TABLET by FDC LTD is a combination medication containing Drotaverine and Mefenamic acid. It is primarily used to relieve various types of pain, especially those associated with muscle spasms and inflammation.

What is DROFEM TABLET used for?

DROFEM TABLET is used to treat abdominal pain, muscle pain, migraine headaches, and functional bowel disorders. It is also effective for dysmenorrhea (menstrual cramps), heavy bleeding during periods, renal colic pain (pain from kidney stones), and pain experienced after surgery.

How does DROFEM TABLET work?

DROFEM TABLET combines two active ingredients: Drotaverine and Mefenamic acid. Drotaverine is an antispasmodic that works by reducing calcium reuptake by cells, which helps to relax smooth muscles and relieve contractions. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that blocks the effect of chemical messengers (prostaglandins) that cause pain and inflammation in the body. Together, these components effectively relieve pain and discomfort.

What is the usual dosage?

The dosage of DROFEM TABLET depends on the specific condition being treated, the severity of symptoms, and individual response to the medicine. It is crucial to follow your doctor's instructions regarding the exact dosage and duration. Generally, it's recommended to take the lowest effective dose for the shortest duration. One common dosage mentioned is one tablet, taken up to three times daily, for a course duration of seven days, with a strength of 80 mg Drotaverine and 250 mg Mefenamic acid. DROFEM TABLET should be swallowed whole with water and can be taken with or after food to minimize stomach upset.

What are the possible side effects?

Common side effects of DROFEM TABLET may include gastrointestinal disturbances, nausea, vomiting, diarrhea, dry mouth, thirst, heartburn, rashes, itching, abdominal pain, indigestion, headache, and dizziness. Some individuals may also experience vertigo, insomnia, low blood pressure (hypotension), fast heart rate, sweating, constipation, and changes in blood cell counts. If these side effects persist or worsen, it is advisable to consult a doctor. More serious, though rare, side effects can include an increased risk of heart attack or stroke, gastrointestinal bleeding, and kidney problems.

Is it safe during pregnancy or breastfeeding?

DROFEM TABLET is generally not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus and may have severe side effects. Similarly, it is contraindicated during breastfeeding as its components can pass into breast milk and may cause adverse effects in nursing infants. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding to discuss alternatives or if the benefits outweigh the risks.

Can it be taken with other medications?

DROFEM TABLET can interact with various medications. It should be used with caution or avoided with:

• Anticoagulants (blood thinners) like warfarin and heparin, as it can increase the risk of bleeding.
• Other pain killers or NSAIDs (e.g., aspirin, ibuprofen) due to an increased risk of gastrointestinal issues and bleeding.
• Antihypertensives (blood pressure medications) such as Aliskiren, Captopril, and Valsartan, as their efficacy may be reduced.
• Anti-diabetic medicines, as DROFEM TABLET can aggravate their blood-glucose-lowering action.
• Corticosteroids like prednisone and dexamethasone, which can increase the risk of stomach ulcers.
• Immunosuppressive agents like cyclosporine and tacrolimus, which may increase the risk of kidney damage.
• Certain antidepressants (e.g., SSRIs and SNRIs) can increase the risk of bleeding. Always inform your healthcare provider about all other medications, including over-the-counter drugs and supplements, to avoid potential interactions.

What precautions should be taken?

• Allergies: Do not take DROFEM TABLET if you are allergic to mefenamic acid, drotaverine, or any of its ingredients.
• Pre-existing Medical Conditions: Inform your doctor if you have a history of asthma, peptic ulcers, porphyria, bleeding problems, severe heart failure, recent heart surgery, or liver or kidney impairment. It is contraindicated in severe kidney or liver disease, and in patients with active bleeding or peptic ulcer disease.
• Alcohol Consumption: Avoid alcohol while taking DROFEM TABLET, as it can increase drowsiness, dizziness, and the risk of stomach bleeding.
• Driving and Operating Machinery: DROFEM TABLET may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating heavy machinery if you experience these symptoms.
• Children: The safety and efficacy of DROFEM TABLET in children have not been established, so it should not be given to them without a doctor's advice.

What happens if a dose is missed?

If you miss a dose of DROFEM TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects.

How should it be stored?

Store DROFEM TABLET in a cool, dry place, away from direct sunlight and moisture. Keep it out of sight and reach of children. The ideal temperature for storage is below 30°C.