Xilingio (m) 25/5/1000mg Tab

XILINGIO (M) 25/5/1000MG Tablet

• Name: XILINGIO (M) 25/5/1000MG Tablet (Brand Name)
• Composition: Each tablet contains Empagliflozin (25 mg), Linagliptin (5 mg), and Metformin (1000 mg).
• Uses:
  • XILINGIO M 25/5/1000MG Tablet is prescribed for adults with type 2 diabetes mellitus to manage blood sugar levels when diet and exercise alone are insufficient.
  • It helps control fasting and after-meal blood glucose, improves insulin sensitivity, decreases glucose production in the liver, promotes urinary excretion of excess glucose, and regulates glucagon secretion.
  • This medication may also offer cardiovascular benefits.
• Dosage and Administration:
  • Take orally, typically once daily, at the same time each day, and usually with food.
  • Swallow the tablet whole; do not crush, chew, or break it.
  • Dosage is determined by your doctor and should not be altered without medical advice.
  • Maintain adequate fluid intake throughout the day.
• Side Effects:
  • Common: Stomach discomfort, diarrhea, nausea, bloating, increased urination, urinary tract infections, genital mycotic infections, upper respiratory tract infection, headache, stuffy or runny nose, sore throat, and decreased appetite. Most digestive symptoms usually improve within a few weeks.
  • Serious: Hypoglycemia (low blood sugar), particularly when combined with insulin or sulfonylureas, and lactic acidosis (a rare but serious risk associated with metformin, especially with alcohol consumption).
• Precautions:
  • Contraindicated in patients with severe kidney problems (eGFR below 30 mL/min/1.73m²), metabolic acidosis (including diabetic ketoacidosis), severe liver disease, type 1 diabetes, or known allergies to its ingredients.
  • Caution is advised during pregnancy and breastfeeding; generally, avoidance is recommended.
  • Avoid alcohol consumption as it increases the risk of lactic acidosis and hypoglycemia.
  • Inform your doctor about any pre-existing health conditions, especially kidney or liver problems, and all other medications you are taking, including diuretics.
  • Temporary discontinuation may be necessary before planned surgeries or contrast imaging tests.
• Storage:
  • Store at room temperature, between 20 and 25°C or below 30°C.
  • Keep in the original container, tightly closed, to protect from moisture and light.
  • Keep out of reach of children.
  • Do not use after the expiry date.

Here are some frequently asked questions about XILINGIO (M) 25/5/1000MG TAB:

What is XILINGIO (M) 25/5/1000MG TAB used for?

XILINGIO (M) 25/5/1000MG TAB is a combination medicine primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus. It helps control both fasting and after-meal blood glucose levels, particularly when diet and exercise alone are insufficient. This medication may also offer cardiovascular benefits, such as reducing the risk of cardiovascular death in adults with type 2 diabetes and established heart disease, and lowering the chances of hospitalization due to heart failure in adults with reduced ejection fraction.

How does XILINGIO (M) 25/5/1000MG TAB work?

XILINGIO (M) 25/5/1000MG TAB contains three active ingredients: Empagliflozin (25mg), Linagliptin (5mg), and Metformin (1000mg).

• Empagliflozin (an SGLT2 inhibitor) works by blocking the kidneys from reabsorbing glucose, leading to excess glucose being removed from the body through urine, thereby lowering blood glucose levels.
• Linagliptin (a DPP-4 inhibitor) increases the levels of incretin hormones, which stimulate the pancreas to release more insulin (especially after meals) and decrease glucagon secretion, helping to control blood sugar.
• Metformin works by decreasing glucose production in the liver, reducing glucose absorption from food, and improving the body's sensitivity to insulin.

What is the usual dosage of XILINGIO (M) 25/5/1000MG TAB?

The daily dose of XILINGIO (M) 25/5/1000MG TAB should be taken exactly as prescribed by your doctor. It is usually taken once daily with meals to help reduce gastrointestinal side effects. Your doctor will determine the appropriate dosage based on factors such as your kidney function, blood sugar control, and response to the medicine. It should be swallowed whole and not crushed, chewed, or broken.

What are the possible side effects of XILINGIO (M) 25/5/1000MG TAB?

Common side effects of XILINGIO (M) 25/5/1000MG TAB may include nausea, diarrhea, abdominal discomfort, bloating, urinary tract infections (UTIs), and genital mycotic (fungal) infections. Other reported side effects include increased urination, nasopharyngitis (inflammation of the throat and nasal passages), back pain, headache, and constipation. Serious side effects like lactic acidosis (due to the metformin component), severe allergic reactions, and pancreatitis are rare but possible. Most mild side effects are temporary and often resolve on their own, but if they persist or worsen, or if any serious side effects occur, you should consult your doctor.

Is XILINGIO (M) 25/5/1000MG TAB safe during pregnancy or breastfeeding?

XILINGIO (M) 25/5/1000MG TAB is generally not recommended during pregnancy or breastfeeding due to potential risks to the baby. Caution is advised, and it's best to consult your doctor to discuss alternative diabetes treatments if you are pregnant, planning to become pregnant, or breastfeeding.

Can XILINGIO (M) 25/5/1000MG TAB be taken with other medications?

XILINGIO (M) 25/5/1000MG TAB can interact with several other medications.

• Diuretics (e.g., furosemide, hydrochlorothiazide) may increase the risk of volume depletion or dehydration when taken with this medicine.
• Insulin or insulin secretagogues (e.g., glimepiride, glargine) can increase the risk of hypoglycemia (low blood sugar).
• Cationic medicines like cimetidine and trimethoprim may interact with the metformin component.
• CYP3A4 inducers like rifampicin may reduce the effectiveness of linagliptin. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using XILINGIO (M) 25/5/1000MG TAB?

• Kidney Health: XILINGIO (M) is contraindicated in patients with severe renal impairment (eGFR below 30 mL/min/1.73m²) and should not be initiated in those with severe kidney disease or on dialysis, as it can worsen their condition. Regular monitoring of kidney function is important.
• Dehydration: This medicine can cause increased urination, leading to potential dehydration. It is important to maintain adequate fluid intake.
• Alcohol: Avoid alcohol consumption as it can lead to unwanted side effects, including an increased risk of lactic acidosis and low blood sugar.
• Liver Health: Caution is advised for patients with liver problems, as the medicine could potentially worsen their condition.
• Infections: XILINGIO (M) may increase the risk of urinary tract infections and genital mycotic infections. Maintaining good hygiene can help prevent these.
• Hypoglycemia: While less likely on its own, the risk of low blood sugar increases when taken with other antidiabetic medications like insulin or sulfonylureas. Monitor blood sugar levels regularly and carry a source of fast-acting sugar.
• Metabolic Acidosis: This medicine is contraindicated in patients with metabolic acidosis, including diabetic ketoacidosis.
• Surgery/Imaging: Inform your doctor before any planned surgeries or contrast imaging tests, as you may need to temporarily stop the medication.

What happens if a dose of XILINGIO (M) 25/5/1000MG TAB is missed?

If you miss a dose of XILINGIO (M) 25/5/1000MG TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Missing doses can lead to high blood sugar levels and associated symptoms.

How should XILINGIO (M) 25/5/1000MG TAB be stored?

XILINGIO (M) 25/5/1000MG TAB should be stored at room temperature, typically between 20 and 25°C. Keep it in its original container with a tight closure to protect it from moisture and light. Avoid storing it in humid places like bathrooms. Always keep the medication out of the sight and reach of children. Do not use the medicine after the expiry date printed on the package.