Valprol Syrup 200 Ml

VALPROL SYRUP 200 ML

VALPROL SYRUP, manufactured by Intas Pharmaceuticals Ltd., is a medication primarily used as an anticonvulsant and mood stabilizer. It is available as a syrup, often with a pineapple flavor.

• Composition: Each 5 mL of VALPROL SYRUP contains 200 mg of Sodium Valproate. Sodium Valproate works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, an inhibitory neurotransmitter that helps stabilize electrical activity and calm nerve impulses.

• Uses: VALPROL SYRUP is prescribed for:

  • Epilepsy/Seizures: Management of various types of seizures, including partial, absence (petit mal), and generalized tonic-clonic (grand mal) seizures, by decreasing abnormal nerve activity in the brain.
  • Bipolar Disorder: Treatment of manic episodes and stabilization of mood swings in individuals with bipolar disorder.
  • Migraine Prevention: Prevention of recurrent migraine headaches.

• Dosage and Administration: The syrup is administered orally, typically with or after food, using a measuring cup or syringe for accurate dosing. Dosage is individualized based on the patient's age, weight, and the condition being treated, and may be increased gradually by a healthcare professional. It should not be stopped suddenly without medical advice, as this can worsen seizures.

• Side Effects: Common side effects can include stomach pain, nausea, vomiting, diarrhea, dizziness, drowsiness, headache, weight changes, hair loss, and tremors. More serious, though rare, side effects may involve liver problems, pancreatitis, severe allergic reactions (e.g., rash, swelling), severe skin reactions, and suicidal thoughts.

• Precautions:

  • Pregnancy and Breastfeeding: VALPROL SYRUP is generally not recommended during pregnancy (Pregnancy Category D) due to the risk of serious birth defects and developmental problems; effective contraception is advised for women of childbearing age. Caution is advised during breastfeeding as the medicine may pass into breastmilk.
  • Liver/Kidney Disease: Contraindicated in patients with severe liver disease, severe hepatitis, urea cycle disorders, or porphyria, and should be used with caution in kidney disease.
  • Alcohol: Avoid alcohol consumption as it can increase dizziness and drowsiness.
  • Activities: May cause drowsiness or dizziness; caution is advised when driving or operating machinery.
  • Interactions: Inform your doctor about all other medications being taken, as interactions can occur with other anticonvulsants, antidepressants, anticoagulants (e.g., warfarin), and oral contraceptives.

• Storage: Store in a cool, dry place away from direct sunlight, typically between 10ºC to 25ºC or below 30ºC. Keep out of reach of children.

Valprol Syrup, containing Sodium Valproate (200 mg/5 ml), is an anti-epileptic medication primarily used to manage various neurological conditions. It is manufactured by Intas Pharmaceuticals Ltd..

What is Valprol Syrup used for?

Valprol Syrup is primarily used to manage epilepsy and various types of seizures in both children and adults. It also treats manic episodes associated with bipolar disorder and can be used for migraine prevention.

How does Valprol Syrup work?

Valprol Syrup works by increasing the levels of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that helps control nerve activity. By enhancing GABA's inhibitory effects, it stabilizes electrical activity in the brain, which reduces the occurrence of seizures and helps regulate mood in bipolar disorder.

What is the usual dosage?

The dosage of Valprol Syrup is determined by a doctor based on the patient's age, body weight, the severity of the condition, and response to the medicine. It is typically given in divided doses, preferably with or after meals, and should not be diluted. For adults with epilepsy, daily doses often range from 1,000 to 2,000 mg (20 to 30 mg/kg body weight per day), potentially increasing to a maximum of 2,500 mg per day if needed. For children, the dose is also weight-dependent and set by a doctor, with extreme caution needed for those under two years of age.

What are the possible side effects?

Common side effects of Valprol Syrup include nausea, vomiting, diarrhoea, abdominal pain, dizziness, drowsiness, tremors, hair loss, and weight gain. Some individuals may also experience headaches, blurred vision, or changes in appetite. Serious, though rare, side effects can include liver problems, pancreatitis, and suicidal thoughts.

Is it safe during pregnancy or breastfeeding?

Valprol Syrup is generally not recommended during pregnancy due to the risk of birth defects and developmental problems in the baby, classified as pregnancy category D. It should only be used if the benefits outweigh the risks in life-threatening situations, under strict medical supervision. During breastfeeding, caution is advised as the medicine can pass into breast milk in small amounts. A doctor should be consulted to weigh the risks and benefits, and close monitoring of the infant is recommended.

Can it be taken with other medications?

Valprol Syrup can interact with several other medications. It may interfere with other anticonvulsants (like phenytoin and carbamazepine), increasing their effects. It can also enhance the effects of antidepressants and antipsychotics. Concurrent use with salicylates (like aspirin) and anticoagulants (like warfarin) may increase the risk of bleeding. Oral contraceptives may interfere with Valprol Syrup's effectiveness.

What precautions should be taken?

Inform your doctor about any pre-existing conditions, especially liver disease, bleeding disorders, mitochondrial disorders, or kidney problems. Valprol Syrup should be used with caution in elderly patients, and dose adjustments may be necessary. It can cause dizziness and drowsiness, so avoid driving or operating heavy machinery until you understand how it affects you. Alcohol consumption should be avoided as it can increase drowsiness and dizziness.

What happens if a dose is missed?

If a dose of Valprol Syrup is missed, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one.

How should it be stored?

Valprol Syrup should be stored at room temperature, away from direct sunlight and moisture, to maintain its effectiveness. It is important to keep the bottle tightly capped and out of reach of children.