Cremagel L (free With Accurate Dosing Dispenser & Finger Gloves) Gel 30 G

Name CREMAGEL L (also known as CremaGel-L, Crema Gel) Gel.

Composition CREMAGEL L Gel contains two active ingredients: Diltiazem (2% w/w) and Lidocaine Hydrochloride (2% w/w). Diltiazem is a calcium channel blocker, and Lidocaine is a local anaesthetic.

Uses CREMAGEL L Gel is primarily used for the management of anal fissures and haemorrhoids. It provides relief from pain, swelling, irritation, itching, and discomfort associated with these anal conditions. The gel works by relaxing the smooth muscles around the anal sphincter, reducing anal pressure, increasing local blood flow to promote healing of fissures, and providing topical anaesthesia and lubrication during ano-rectal procedures.

Dosage and Administration This medicine is for external (anal) use only. A thin layer of the gel should be gently applied to the affected perianal skin or inside the anus area, typically 2-3 times daily or as directed by a healthcare professional. Before application, clean and dry the affected area. It is crucial to wash hands thoroughly before and after applying the gel. A finger covering or disposable gloves can be used for application.

Side Effects Common side effects may include local reactions at the application site such as burning sensation, itching, redness, and swelling. Other reported side effects include headache, nausea, light-headedness, and dizziness. If any side effects persist or worsen, consult a doctor.

Precautions Consult your doctor before using CREMAGEL L if you have any pre-existing medical conditions, especially severe heart block, liver or kidney impairment, or if you are pregnant or breastfeeding. Avoid contact with eyes, nose, or mouth; in case of accidental exposure, rinse with water and seek medical attention. Do not stop using the medicine suddenly. Be cautious if experiencing light-headedness or dizziness, and avoid driving or operating machinery. Inform your doctor about any other medications you are taking, as interactions may occur with antihypertensives and CYP3A4 inhibitors.

Storage Store CREMAGEL L Gel below 30°C (or 25°C) in a cool and dry place, away from direct sunlight and out of reach of children.

What is CREMAGEL L used for?

CREMAGEL L is primarily used for the management of anal fissures, which are small tears in the lining of the anus that can cause significant pain and discomfort. It is also used to relieve pain, swelling, inflammation, and discomfort associated with hemorrhoids (piles) and other anorectal conditions. Additionally, it can provide topical anesthesia and lubrication during ano-rectal procedures and examinations.

How does CREMAGEL L work?

CREMAGEL L contains two active ingredients: Diltiazem and Lidocaine. Diltiazem, a calcium channel blocker, works by relaxing the smooth muscle around the anal sphincter. This action increases local blood flow, reduces anal pressure, and helps alleviate pain and spasms, thereby promoting the healing of anal fissures. Lidocaine Hydrochloride is a local anesthetic that numbs the affected area by blocking nerve signals, providing quick pain relief.

How should I apply CREMAGEL L and what is the usual dosage?

CREMAGEL L is for external use only. Ensure your hands are clean before application. Gently apply a thin layer of the gel to the affected perianal skin or inside the anus area. It is typically applied 2-3 times daily or as directed by your doctor. Wash your hands thoroughly after application to avoid spreading the gel. Avoid contact with your eyes, nose, or mouth; if accidental exposure occurs, rinse with water and seek medical advice promptly.

What are the possible side effects of CREMAGEL L?

Common side effects of CREMAGEL L are usually temporary and may include local reactions at the application site such as burning, itching, redness, or swelling. Other potential side effects can include headache and nausea. If these symptoms persist, worsen, or cause concern, it is advisable to consult your doctor.

Is CREMAGEL L safe during pregnancy or breastfeeding?

If you are pregnant, caution is advised while using CREMAGEL L, and it should only be used if clearly needed and the benefits outweigh the risks. It is best to consult your doctor before using this medicine during pregnancy. Lidocaine, one of the active ingredients, is excreted in human milk, so caution is also advised for breastfeeding mothers, and consulting a healthcare provider is recommended.

Can CREMAGEL L be taken with other medications?

While CREMAGEL L is for external use and less likely to interact systemically, certain interactions are noted. Antihypertensives (like amlodipine and lisinopril) may interact with CREMAGEL L's diltiazem component, potentially leading to excessively low blood pressure. CYP3A4 inhibitors (such as ketoconazole and ritonavir) can increase diltiazem levels in the bloodstream. It is essential to inform your doctor about all medications, supplements, and herbal products you are taking.

What precautions should I take while using CREMAGEL L?

CREMAGEL L is for external use only. Do not apply it to broken or infected skin unless advised by a doctor. Patients with severe heart block or certain heart conditions should use it with caution due to the diltiazem component. If you experience lightheadedness or dizziness, avoid driving or operating machinery until these sensations subside. Limit alcohol consumption as it can interact with diltiazem and increase the risk of side effects like dizziness. Also, inform your doctor if you have liver or kidney impairment.

What happens if a dose of CREMAGEL L is missed?

If you miss a dose of CREMAGEL L, apply it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular application schedule. Do not apply a double amount to compensate for a missed dose.

How should CREMAGEL L be stored?

CREMAGEL L should be stored in a cool, dry place, below 25°C, and away from direct sunlight. It is important to keep it out of the reach and sight of children.