NUFORCE 50 TABLET

Name

Brand Name: Nuforce 50 Tablet Common Name: Fluconazole Tablet

Composition

Each NUFORCE 50 TABLET contains 50 mg of Fluconazole. Fluconazole is an antifungal agent belonging to the class of triazole antifungals.

Uses

NUFORCE 50 TABLET is primarily used to treat a wide range of fungal and yeast infections. It works by inhibiting the growth of fungi by disrupting their cell membrane formation.

It is prescribed for conditions such as:

• Vaginal yeast infections (vaginal candidiasis).
• Oral and esophageal candidiasis (thrush, including denture sore mouth).
• Systemic candidiasis (fungal infections affecting the blood, brain, heart, eyes, or other organs).
• Cryptococcal meningitis (a fungal infection in the brain and spinal cord).
• Dermatomycoses, including athlete's foot (tinea pedis), ringworm (tinea corporis), and jock itch (tinea cruris).
• Fungal infections of fingernails and toenails.
• It is also used as a preventive measure against candidal infections in immunocompromised patients, such as those undergoing bone marrow transplants, chemotherapy, or radiation therapy.

Dosage and Administration

NUFORCE 50 TABLET should be taken in the dose and duration as prescribed by your doctor. It can be swallowed whole with or without food. The dosage and length of treatment depend on the specific condition being treated. It is important to complete the full course of treatment to ensure the infection is completely cured and to prevent recurrence.

Side Effects

Common side effects may include:

• Headache
• Nausea
• Vomiting
• Stomach pain or abdominal pain
• Diarrhea
• Rash
• Increased alanine aminotransferase and aspartate aminotransferase (liver enzymes)
• Dizziness
• Altered food tastes
• Hair loss (rare)

More serious side effects, though rare, warrant immediate medical attention, such as signs of an allergic reaction (rash, swelling of lips/throat/face, difficulty breathing), or signs of liver problems (yellow skin/eyes, persistent tiredness, dark urine).

Precautions

• Pregnancy and Breastfeeding: NUFORCE 50 TABLET is generally not recommended during pregnancy or breastfeeding unless specifically advised by a doctor, due to potential risks to the developing baby or infant.
• Liver and Kidney Problems: Use with caution in patients with liver or kidney disease. Dosage adjustments may be necessary, and liver function may be monitored during prolonged treatment.
• Heart Conditions: Inform your doctor if you have a history of heart problems or abnormal levels of potassium, calcium, or magnesium in your blood.
• Drug Interactions: Inform your doctor about all current medications, as Fluconazole can interact with various drugs, including antacids, heart rhythm regulators, antibiotics, and blood thinners. Avoid antacid treatments within one hour before or two hours after taking NUFORCE 50 TABLET.
• Alcohol Consumption: Avoid or limit alcohol consumption during treatment as it may increase the risk of liver damage.
• Driving and Operating Machines: This medicine may cause dizziness, so avoid driving or operating heavy machinery if you experience this side effect.
• Allergies: Do not take if allergic to Fluconazole or any other components of the tablet.

Storage

Store NUFORCE 50 TABLET below 30°C (preferably between 20°C to 25°C). Keep the medicine in its original package, tightly closed, and protect it from light and moisture. Keep out of sight and reach of children.

NUFORCE 50 TABLET by MANKIND PHARMA LTD. contains Fluconazole, an antifungal medication used to treat various fungal and yeast infections.

What is NUFORCE 50 TABLET used for?

NUFORCE 50 TABLET is primarily used to treat a wide range of fungal infections caused by yeasts like Candida and fungi like Cryptococcus. These include systemic candidiasis (infections affecting blood, brain, heart, eyes, or urinary tract), mucosal candidiasis (thrush in the mouth, throat, and esophagus), vaginal yeast infections (vaginal candidiasis), and cryptococcal meningitis (a fungal infection of the brain and spinal cord). It is also effective against certain skin fungal infections such as ringworm, athlete's foot, and jock itch. Additionally, it can be prescribed to prevent fungal infections in individuals with weakened immune systems, such as those with HIV, undergoing chemotherapy or radiation therapy, or who have received a bone marrow transplant.

How does NUFORCE 50 TABLET work?

NUFORCE 50 TABLET works as an antifungal agent by inhibiting an enzyme called lanosterol 14-alpha-demethylase, which is vital for the synthesis of ergosterol. Ergosterol is a crucial component of the fungal cell membrane. By blocking its production, Fluconazole disrupts the integrity and formation of the fungal cell membrane, ultimately leading to the death or inhibited growth of the fungi.

What is the usual dosage of NUFORCE 50 TABLET?

The dosage of NUFORCE 50 TABLET varies significantly based on the type and severity of the fungal infection, as well as individual patient factors such as age and kidney function. For adults, typical daily doses can range from 50 mg to 400 mg. A single 150 mg dose is often prescribed for vaginal thrush. In children, the dosage is determined by body weight, usually between 3 mg and 12 mg per kilogram once daily. Your doctor will determine the appropriate dose and duration of treatment for your specific condition.

What are the possible side effects of NUFORCE 50 TABLET?

Common side effects associated with NUFORCE 50 TABLET include headache, stomach discomfort, nausea, vomiting, diarrhea, abdominal pain, indigestion, dizziness, changes in taste, and rash.

More serious but less common side effects require immediate medical attention. These can include severe allergic reactions (e.g., widespread rash, swelling of the lips, mouth, or throat, difficulty breathing), liver problems (indicated by yellowing of the skin or eyes, dark urine, pale stools, persistent stomach pain, unusual tiredness, or loss of appetite), heart rhythm problems (such as a fast or irregular heartbeat, dizziness, or fainting), severe skin reactions (like blistering or peeling skin), and adrenal insufficiency (characterized by chronic fatigue, muscle weakness, loss of appetite, weight loss, or abdominal pain).

Is NUFORCE 50 TABLET safe during pregnancy or breastfeeding?

Pregnancy: NUFORCE 50 TABLET is generally not recommended during pregnancy, particularly in the first trimester, unless your doctor deems it absolutely necessary for severe or life-threatening fungal infections. For common conditions like thrush, topical treatments are often preferred. High doses (400 to 1200 mg per day for many weeks) of fluconazole have been rarely associated with a pattern of birth defects. It is important to use an effective form of birth control during treatment and for at least one week after the last dose.

Breastfeeding: Fluconazole, the active ingredient, can pass into breast milk. While the amounts are generally considered less than the doses used to treat infants directly, it's advisable to consult your doctor before taking it while breastfeeding. Mild side effects in breastfed infants, such as stomach upset or diarrhea, have been reported in some cases. If your baby has a fungal infection, the amount of fluconazole in breast milk is typically not sufficient to treat it, and the baby would require their own medication.

Can NUFORCE 50 TABLET be taken with other medications?

NUFORCE 50 TABLET can interact with a variety of other medications, potentially altering their effects or increasing the risk of side effects.

Do not take NUFORCE 50 TABLET with: Astemizole, terfenadine, cisapride, pimozide, quinidine, erythromycin, adagrasib, flibanserin, lomitapide, lonafarnib, triazolam, and other medications that can cause heart rhythm changes.

Inform your doctor if you are taking any of the following, as dose adjustments or close monitoring may be necessary: Blood thinners (e.g., warfarin, dabigatran, clopidogrel), oral medications for diabetes (e.g., glipizide, glyburide), certain blood pressure medicines (e.g., hydrochlorothiazide, amlodipine, losartan), organ transplant medications (e.g., cyclosporine, tacrolimus, sirolimus), rifampicin or rifabutin (for tuberculosis), certain antivirals for HIV or hepatitis, certain cholesterol-lowering drugs (statins), certain antidepressants (e.g., amitriptyline, escitalopram), certain seizure medications (e.g., carbamazepine, phenytoin), NSAIDs (e.g., ibuprofen), amiodarone (for heart problems), certain opioid pain medications, theophylline, and steroid medications. Always provide your doctor with a complete list of all prescription, over-the-counter, herbal, and vitamin supplements you are using.

What precautions should be taken while taking NUFORCE 50 TABLET?

Before taking NUFORCE 50 TABLET, inform your doctor if you have any pre-existing medical conditions, especially liver, kidney, or heart problems, or if you have abnormal levels of potassium, calcium, or magnesium in your blood. Be vigilant for signs of serious skin reactions or liver problems, such as yellowing of the skin or eyes, dark urine, or persistent stomach pain. If you experience dizziness, avoid driving or operating heavy machinery. It is crucial to complete the entire course of medication as prescribed by your doctor, even if your symptoms improve, to ensure the infection is fully cleared and to prevent its recurrence. Also, it is advisable to avoid or limit alcohol consumption during treatment, as it may increase the risk of liver damage.

What happens if a dose of NUFORCE 50 TABLET is missed?

If you miss a dose of NUFORCE 50 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one.

How should NUFORCE 50 TABLET be stored?

NUFORCE 50 TABLET should be stored at room temperature, typically below 25°C or 30°C (68°F to 86°F), in a cool, dry place. Keep the tablets protected from light and moisture. Always ensure that the medication is kept out of the reach of children. Do not use the medicine beyond its expiration date.