Xmet Trio 500/0.2/1 Tab

XMET TRIO 500/0.2/1 TABLET

XMET TRIO 500/0.2/1 TABLET is a medication manufactured by Glenmark Pharmaceuticals Ltd. and is prescribed for the management of Type 2 Diabetes Mellitus.

Composition Each tablet of XMET TRIO 500/0.2/1 contains a combination of three active ingredients:

• Metformin Hydrochloride: 500 mg
• Voglibose: 0.2 mg
• Glimepiride: 1 mg

These ingredients work synergistically to control blood sugar levels. Glimepiride, a sulfonylurea, increases insulin release from the pancreas. Metformin, a biguanide, reduces glucose production in the liver, delays intestinal glucose absorption, and enhances insulin sensitivity. Voglibose, an alpha-glucosidase inhibitor, prevents the breakdown of complex sugars in the intestine, thereby lowering post-meal glucose spikes.

Uses XMET TRIO 500/0.2/1 TABLET is used for the treatment of Type 2 Diabetes Mellitus in adults whose blood sugar levels are not adequately controlled by diet, exercise, or single/dual anti-diabetic therapies. It helps to regulate blood glucose, improve insulin response, and reduce the risk of diabetes complications such as kidney damage, blindness, nerve problems, heart attack, or stroke.

Dosage and Administration This medicine should be taken orally as directed by a healthcare professional. It is typically administered with or immediately before meals, swallowed whole with a glass of water, and not crushed, chewed, or broken. For optimal results, it is recommended to take the tablet at the same time each day. The dosage may vary based on individual blood sugar levels and response to treatment. Do not stop taking this medicine without consulting your doctor.

Side Effects Common side effects may include:

• Hypoglycemia (low blood sugar levels), characterized by dizziness, sweating, hunger pangs, and headache.
• Taste changes, nausea, vomiting, diarrhea, stomach pain, and flatulence.
• Headache and upper respiratory symptoms.
• Some patients might experience weight gain.
• Long-term use may lead to Vitamin B12 deficiency.

Serious but rare side effects can include lactic acidosis (a serious condition affecting liver and kidneys) and bullous pemphigoid (a serious skin reaction).

Precautions

• Contraindications: Do not use if allergic to any components, or in patients with Type 1 Diabetes Mellitus, diabetic ketoacidosis, severe kidney or liver disease, acute metabolic acidosis, severe infection, acute heart conditions, or during pregnancy and breastfeeding.
• Interactions: Inform your doctor about all medicines you are taking, including other antidiabetic drugs (e.g., insulin), diuretics, corticosteroids, and thyroid medicines, as interactions can occur.
• Alcohol: Avoid alcohol consumption as it can increase the risk of low blood sugar.
• Monitoring: Regular monitoring of blood sugar levels, liver function, blood cell counts, and TSH levels is recommended.
• Other Warnings: Caution is advised in older patients. Inform your doctor if you have heart disease, pancreatitis, or low vitamin B12 levels. Discontinue use temporarily if undergoing CT/MRI with contrast media, or if experiencing dehydration, vomiting, or prolonged fasting.

Storage Store XMET TRIO 500/0.2/1 TABLET in a cool and dry place, away from direct sunlight, at room temperature (below 30°C or between 10°C to 25°C). Keep it in its original packaging and out of sight and reach of children and pets.

What is XMET TRIO 500/0.2/1 TAB used for?

XMET TRIO 500/0.2/1 TAB is used to manage Type 2 Diabetes Mellitus in adults whose blood sugar levels are not adequately controlled by diet, exercise, or single anti-diabetic medications. It helps control high blood glucose levels and can also prevent serious complications of diabetes such as kidney damage, blindness, nerve problems, heart attack, or stroke.

How does XMET TRIO 500/0.2/1 TAB work?

This medicine is a combination of three active ingredients: Glimepiride, Metformin, and Voglibose, each working differently to control blood sugar. Glimepiride stimulates the pancreas to release more insulin, which helps lower blood sugar. Metformin reduces glucose production in the liver, delays glucose absorption from the intestines, and enhances the body's response to insulin. Voglibose works by inhibiting enzymes in the gut that break down complex carbohydrates into simple sugars, thus slowing down the absorption of sugar from food and preventing sharp rises in blood sugar after meals.

What is the usual dosage for XMET TRIO 500/0.2/1 TAB?

The dosage of XMET TRIO 500/0.2/1 TAB should be taken exactly as prescribed by your doctor. It is typically recommended to swallow the tablet whole with a glass of water, with food, and at the same time each day for optimal results and to avoid stomach upset. Do not crush, chew, or break the tablet, and do not exceed the prescribed dose.

What are the possible side effects of XMET TRIO 500/0.2/1 TAB?

Common side effects can include hypoglycemia (low blood glucose levels), characterized by dizziness, sweating, and hunger pangs. Other potential side effects are taste changes, nausea, diarrhea, stomach pain, headache, upper respiratory symptoms, metallic taste in the mouth, and flatulence. Less common but serious side effects can include lactic acidosis, a rare condition where too much lactic acid accumulates in the blood, and a decrease in vitamin B12 levels with long-term use.

Is XMET TRIO 500/0.2/1 TAB safe during pregnancy or breastfeeding?

XMET TRIO 500/0.2/1 TAB is generally not recommended during pregnancy and is contraindicated, especially in the second and third trimesters, as it may harm the fetus. Similarly, it is not recommended for use while breastfeeding as the medicine may pass into breast milk and potentially harm the nursing child. It is crucial to consult your doctor for advice if you are pregnant, planning to conceive, or breastfeeding.

Can XMET TRIO 500/0.2/1 TAB be taken with other medications?

XMET TRIO 500/0.2/1 TAB can interact with several other medications. Combining it with other anti-diabetic medicines like insulin can increase the risk of low blood sugar. Diuretics (water pills), corticosteroids, and certain thyroid medicines can reduce its effectiveness. It may also interact with anti-bacterials, antifungals, certain anticancer drugs, disopyramide, fenyramidol, pentoxifylline, and blood thinners. Always inform your doctor about all medications, including herbal remedies and supplements, you are currently taking.

What precautions should be taken while taking XMET TRIO 500/0.2/1 TAB?

This medicine should not be taken if you have Type 1 diabetes mellitus, diabetic ketoacidosis, or severe kidney or liver disease. Inform your doctor if you have heart disease, pancreatitis, a history of gastrointestinal diseases, or a low vitamin B12 level. Alcohol consumption should be avoided as it increases the risk of low blood sugar and lactic acidosis. Regular monitoring of blood sugar levels is essential, and your doctor may also recommend checking thyroid-stimulating hormone (TSH) and kidney function. Caution is advised when driving or operating machinery due to the risk of hypoglycemia affecting concentration.

What happens if a dose of XMET TRIO 500/0.2/1 TAB is missed?

If you miss a dose of XMET TRIO 500/0.2/1 TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one, as this can lead to very low blood sugar levels (hypoglycemia). It's advisable to contact your doctor for specific guidance if you frequently miss doses or have concerns.

How should XMET TRIO 500/0.2/1 TAB be stored?

Store XMET TRIO 500/0.2/1 TAB in a cool, dry place, away from direct sunlight. Keep the medicine in its original packaging, tightly closed, and out of sight and reach of children.