Tglip M 500

TGLIP M 500 is a combination medication manufactured by INTAS PHARMACEUTICALS LTD, primarily used for the management of type 2 diabetes mellitus.

Composition

TGLIP M 500 contains two active ingredients:

• Metformin Hydrochloride: 500 mg
• Teneligliptin: 20 mg

Uses

TGLIP M 500 is prescribed for adults with type 2 diabetes mellitus. It improves glycemic control by enhancing insulin sensitivity, reducing hepatic glucose production, and increasing insulin levels while decreasing glucagon levels in the body. It is used when diet and exercise alone, or metformin alone, do not provide adequate blood sugar control.

Dosage and Administration

TGLIP M 500 should be taken orally, preferably with meals, or as advised by a physician. The tablet should be swallowed whole with a glass of water and not crushed or chewed. The dosage and duration of therapy are determined by the doctor based on individual needs and response to treatment. Typically, it is recommended once daily.

Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea
• Headache, stomach ache/abdominal discomfort
• Flatulence
• Low blood sugar levels (hypoglycemia), especially when used with insulin or sulfonylurea

Serious but rare side effects include lactic acidosis, which requires immediate medical attention and presents with symptoms like cold hands/feet, dizziness, unusual muscle pain, and difficulty breathing.

Precautions

TGLIP M 500 is contraindicated in patients with severe kidney impairment, severe uncontrollable diabetes, type 1 diabetes, diabetic ketoacidosis, or known allergy to its components. Caution is advised for patients with liver disease, heart problems, or a history of kidney disease. Alcohol consumption should be limited or avoided due to an increased risk of lactic acidosis. It is not recommended during pregnancy or breastfeeding. Regular monitoring of blood sugar and kidney function is advisable during therapy. Long-term use may cause Vitamin B12 deficiency.

Storage

TGLIP M 500 should be stored in a cool and dry place, away from direct sunlight and moisture, preferably between 10ºC to 25ºC or below 30ºC. Keep it out of sight and reach of children.

What is TGLIP M 500 used for?

TGLIP M 500 is an antidiabetic medication primarily used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is often prescribed when diet and exercise alone are not sufficient to control blood sugar. This medicine helps improve glycemic control and can reduce the risk of serious complications associated with diabetes, such as kidney damage and vision loss.

How does TGLIP M 500 work?

TGLIP M 500 contains two active ingredients: Metformin and Teneligliptin. Metformin, a biguanide, works by decreasing the production of glucose in the liver, reducing glucose absorption from the intestines, and enhancing the body's sensitivity to insulin. Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of incretin hormones, which in turn boosts insulin secretion from the pancreas when blood sugar is high and reduces the hormones that raise blood sugar levels. Together, these actions help to lower both fasting and post-meal blood sugar levels.

What is the usual dosage for TGLIP M 500?

TGLIP M 500 should be taken orally with meals, as directed by your doctor. Taking it with food can help reduce stomach upset. The dosage and duration of treatment will be determined by your doctor based on your age, medical condition, and response to the medication. It is important not to crush, chew, or break the tablet, and not to exceed the prescribed dose.

What are the possible side effects of TGLIP M 500?

Common side effects of TGLIP M 500 can include nausea, vomiting, diarrhea, headache, stomach ache, abdominal pain or discomfort, and flatulence. Low blood sugar levels (hypoglycemia) can occur, especially if taken with other diabetes medications like insulin or sulfonylureas. A serious, though rare, side effect is lactic acidosis, which requires immediate medical attention and may present with symptoms like muscle cramps, abdominal pain, vomiting, severe fatigue, or difficulty breathing.

Is TGLIP M 500 safe during pregnancy or breastfeeding?

TGLIP M 500 is generally not recommended during pregnancy due to limited information on its effects and potential risks to the fetus. It is also not recommended for use in breastfeeding mothers as its components may pass into breast milk and could cause unwanted effects in the nursing baby. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor for safer alternatives.

Can TGLIP M 500 be taken with other medications?

TGLIP M 500 can interact with certain medications. It is crucial to inform your doctor about all medicines you are taking, including over-the-counter drugs and herbal supplements. Some medications that may interact include cationic medicines (e.g., amiloride, digoxin, morphine), diuretics (e.g., furosemide), glucose-altering medicines (e.g., isoniazid), other antidiabetics (e.g., glimepiride, pioglitazone), certain antibiotics (e.g., rifampicin, tetracycline), and corticosteroids. Discontinuation of TGLIP M 500 at least 48 hours prior to the intake of iodinated contrast media may be necessary.

What precautions should be taken while using TGLIP M 500?

Before taking TGLIP M 500, inform your doctor if you have liver, kidney, or heart problems (including heart failure or irregular heartbeat), severe infection, severe trauma, adrenal insufficiency, bowel obstruction, or a history of lactic acidosis. Avoid excessive alcohol consumption, as it increases the risk of lactic acidosis. Regular monitoring of blood sugar levels and kidney function tests is advisable during treatment. TGLIP M 500 is not recommended for children under 18 years of age.

What happens if a dose of TGLIP M 500 is missed?

If you miss a dose of TGLIP M 500, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take extra medicine or a double dose to make up for the missed one.

How should TGLIP M 500 be stored?

TGLIP M 500 should be stored in a cool, dry place, away from direct sunlight, and in its original packaging. Keep it out of sight and reach of children and pets. The optimal storage temperature is generally between 10-25°C.