Glucreta Sm 10/100/1000 Tab

GLUCRETA SM 10/100/1000 Tablet

GLUCRETA SM 10/100/1000 Tablet is a combination medicine manufactured by Torrent Pharmaceuticals Ltd., designed for the management of type 2 diabetes mellitus.

• Composition GLUCRETA SM 10/100/1000 Tablet contains three active ingredients:

  • Dapagliflozin (10 mg): A sodium-glucose cotransporter-2 (SGLT2) inhibitor that lowers blood glucose by increasing glucose excretion through urine.
  • Sitagliptin (100 mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin production from pancreatic beta cells and reduces glucagon secretion when blood sugar levels are high.
  • Metformin (1000 mg): A biguanide that reduces glucose production by the liver and improves the body's sensitivity to insulin, aiding glucose uptake by tissues.

• Uses GLUCRETA SM 10/100/1000 Tablet is prescribed for adults with type 2 diabetes mellitus to improve blood sugar control. It is used as an adjunct to diet and exercise when single or dual therapy is insufficient. This medicine may also help with weight loss and protect the heart and kidneys in some individuals with type 2 diabetes and cardiovascular disease.

• Dosage and Administration The tablet should be swallowed whole with water, without chewing or crushing. It can be taken with or without food, preferably at the same time each day to maintain consistent blood glucose levels. The dosage is determined by a healthcare professional, and it is crucial not to exceed the recommended dose or discontinue the medicine without consulting your doctor.

• Side Effects

  • Common Side Effects: Genital infections (mycotic infections), nasopharyngitis (inflammation of the throat and nasal passages), urinary tract infections (UTIs), diarrhea, headache, nausea, and vomiting.
  • Serious Side Effects: Though rare, these may include lactic acidosis (weakness, difficulty breathing, stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), pancreatitis (severe stomach pain), and serious allergic reactions (rash, swelling, breathing problems).

• Precautions

  • Allergies: Do not use if you have a history of serious allergic reactions to any of its components.
  • Kidney/Liver Impairment: Not recommended for individuals with severe renal impairment or those undergoing dialysis, or those with severe liver problems, due to risks associated with metformin.
  • Pregnancy and Breastfeeding: Consult your doctor if pregnant, planning to conceive, or breastfeeding, as information on its use during these periods is limited or not recommended.
  • Alcohol: Excessive alcohol intake should be avoided as it may increase the risk of lactic acidosis and other complications.
  • Drug Interactions: Inform your doctor about all other medications, including diuretics, certain heart medicines (e.g., beta-blockers, ACE inhibitors), carbonic anhydrase inhibitors, and insulin or sulfonylureas, as these can interact with GLUCRETA SM.
  • Driving/Operating Machinery: If you experience dizziness or fatigue, avoid driving or operating machinery until you feel better.

• Storage Store the GLUCRETA SM Tablet in a cool and dry place, ideally below 30°C, away from direct sunlight, moisture, and humidity. Keep it out of the sight and reach of children.

GLUCRETA SM 10/100/1000 TAB is a combination medication used to manage Type 2 Diabetes Mellitus. Below are some frequently asked questions about this medicine.

What is GLUCRETA SM 10/100/1000 TAB used for?

GLUCRETA SM 10/100/1000 TAB is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone, or therapy with single or dual antidiabetic medications, are not sufficient to control blood sugar levels. It helps to lower blood sugar, improve insulin sensitivity, and can also contribute to weight loss and protection of the heart and kidneys in some individuals.

How does GLUCRETA SM 10/100/1000 TAB work?

This medicine is a triple combination of Dapagliflozin, Sitagliptin, and Metformin, each working through different mechanisms to control blood sugar.

• Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by causing the kidneys to remove excess glucose from the body through urine.
• Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of natural substances (incretins) in the body. These incretins stimulate the pancreas to release more insulin when blood sugar is high and reduce the production of glucagon, a hormone that raises blood sugar.
• Metformin is a biguanide that primarily decreases glucose production in the liver, reduces the absorption of sugar from the intestines, and improves the body's sensitivity to insulin.

What is the usual dosage for GLUCRETA SM 10/100/1000 TAB?

The dosage of GLUCRETA SM 10/100/1000 TAB is determined by your doctor based on your individual needs, blood glucose control, and tolerability. It is typically taken orally, once or twice daily, with meals to help reduce stomach upset and improve absorption. It's crucial to take the medicine at the same time(s) each day for optimal results and to swallow the tablet whole without crushing, chewing, or breaking it.

What are the possible side effects of GLUCRETA SM 10/100/1000 TAB?

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, headache, flatulence, and loss of appetite. Some individuals might also experience urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, and genital fungal infections. Less common but serious side effects can include lactic acidosis, severe abdominal pain (a symptom of pancreatitis), and allergic reactions (rash, itching, swelling).

Is GLUCRETA SM 10/100/1000 TAB safe during pregnancy or breastfeeding?

GLUCRETA SM is generally not recommended during pregnancy or for breastfeeding women due to limited information on its effects in these situations. It is important to consult your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

Can GLUCRETA SM 10/100/1000 TAB be taken with other medications?

It is important to inform your doctor about all other medications, including over-the-counter drugs, herbal remedies, and supplements you are taking, as they may interact with GLUCRETA SM. Particular care should be taken if you are using diuretics (water pills), certain blood pressure medications, insulin, or sulfonylureas, as these can increase the risk of dehydration, low blood pressure, or extremely low blood sugar.

What precautions should be taken while taking GLUCRETA SM 10/100/1000 TAB?

Several precautions should be observed:

• Kidney and Liver Health: Inform your doctor if you have kidney or liver problems, as this medicine is not recommended for severe cases and may require dose adjustments.
• Alcohol Consumption: Avoid consuming large amounts of alcohol as it can increase the risk of lactic acidosis and hypoglycemia.
• Hydration: Drink plenty of fluids to prevent dehydration, especially as dapagliflozin increases glucose excretion through urine.
• Hypoglycemia: Be aware of symptoms of low blood sugar (hypoglycemia), such as shakiness, sweating, rapid heartbeat, and confusion. Carry a source of fast-acting sugar to manage these symptoms.
• Diet and Exercise: This medication is part of a comprehensive treatment plan that includes a healthy diet, regular exercise, and weight reduction as advised by your doctor.
• Surgery: You may need to stop taking Metformin before certain surgical procedures and restart after a specified period.
• Pancreatitis/Allergic Reactions: Seek immediate medical attention if you experience severe abdominal pain (signs of acute pancreatitis) or allergic reactions like swelling of the face, tongue, or lips.

What happens if a dose of GLUCRETA SM 10/100/1000 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should GLUCRETA SM 10/100/1000 TAB be stored?

Store GLUCRETA SM 10/100/1000 TAB in a cool and dry place, typically below 30°C (or between 10ºC to 25ºC), away from direct sunlight and moisture. Keep it out of reach of children and pets. Do not use the medicine past its expiry date.