Midodrive 2.5 Mg Tablet (20 Tab)

MIDODRIVE 2.5 MG TABLET

MIDODRIVE 2.5 MG TABLET is a medication manufactured by SUN PHARMA LABORATORIES LTD., primarily used to manage low blood pressure.

• Name:
  • Brand Name: MIDODRIVE 2.5 MG TABLET
  • Common Name: Midodrine Hydrochloride
• Composition:
  • Active Ingredient: Midodrine Hydrochloride 2.5 mg
• Uses: MIDODRIVE is an antihypotensive drug prescribed for the treatment of orthostatic hypotension, a condition characterized by a sudden drop in blood pressure when standing up from a sitting or lying position. It works by constricting blood vessels, thereby increasing blood pressure and alleviating symptoms such as dizziness, lightheadedness, fainting, blurred vision, and weakness.
• Dosage and Administration: The usual starting dose for adults is 2.5 mg, typically taken two to three times daily. Doses should be administered during daytime hours when the patient is upright, with a suggested interval of 3-4 hours between doses. To minimize the risk of supine hypertension (high blood pressure when lying down), the last dose should be taken at least four hours before bedtime. Tablets should be swallowed whole with water and can be taken with or without food. Do not crush, chew, or break the medicine.
• Side Effects: Common side effects may include headache, nausea, rash, piloerection (goosebumps), itching (especially of the scalp), pain or difficulty in urination, and supine hypertension. Serious side effects to report immediately include excessive supine hypertension (pounding in the ears, blurred vision, chest pain), slow heartbeat, or allergic reactions.
• Precautions: MIDODRIVE is contraindicated in patients with severe heart disease, severe kidney disease, high blood pressure (especially supine hypertension), elevated eye pressure (glaucoma), difficulty urinating, an overactive thyroid gland, or an enlarged prostate. Caution is advised for diabetic patients or those taking other medications that affect heart rate, such as cardiac glycosides. Regular monitoring of blood pressure (both standing and supine) and kidney function is recommended.
• Storage: Store MIDODRIVE tablets at room temperature, away from light and moisture. Keep out of sight and reach of children.

What is MIDODRIVE 2.5 MG TABLET used for?

MIDODRIVE 2.5 MG TABLET is primarily used to treat low blood pressure, also known as hypotension, especially in individuals who experience dizziness, lightheadedness, fainting, blurred vision, weakness, or difficulty concentrating when standing up quickly from a seated or lying position (orthostatic hypotension).

How does MIDODRIVE 2.5 MG TABLET work?

MIDODRIVE 2.5 MG TABLET contains Midodrine, which is an alpha-1 selective adrenergic receptor agonist. It works by being converted into an active metabolite, desglymidodrine, that activates specific receptors on blood vessels, causing them to constrict or narrow. This constriction increases peripheral vascular resistance, leading to an elevation in blood pressure.

What is the usual dosage for MIDODRIVE 2.5 MG TABLET?

The usual starting dose of MIDODRIVE 2.5 MG TABLET is typically 2.5 mg three times daily. Doses should be spaced at least 3 hours apart and taken during daytime hours when you are most likely to be upright. It is crucial not to take a dose after the evening meal or less than 4 hours before bedtime to minimize the risk of high blood pressure while lying down (supine hypertension). The tablets can be taken with or without food, as directed by your doctor. The maximum recommended daily dose should not exceed 30 mg.

What are the possible side effects of MIDODRIVE 2.5 MG TABLET?

Common side effects include increased blood pressure while lying down (supine hypertension), headache, nausea, rash, urinary retention, difficulty in urination, flushing (a sense of warmth), goosebumps, tingling sensation, itching, and chills. More serious side effects, such as severely slowed heart rate or dangerously high blood pressure (indicated by severe headache, pounding heartbeat, blurred vision, anxiety, or chest pain), should be reported to your doctor immediately.

Is MIDODRIVE 2.5 MG TABLET safe during pregnancy or breastfeeding?

MIDODRIVE 2.5 MG TABLET is generally not recommended or is contraindicated during pregnancy due to limited information on its safety in pregnant women and potential associated risks. Women of childbearing potential should use proper birth control measures while on this medication. For breastfeeding mothers, the effects of Midodrine on a nursing infant are not well-known, and it is also not recommended. Always consult your healthcare provider before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

Can MIDODRIVE 2.5 MG TABLET be taken with other medications?

It is important to inform your doctor about all medications you are currently taking, including over-the-counter drugs and herbal supplements, as MIDODRIVE 2.5 MG TABLET can interact with several medicines. Avoid using it with drugs that can increase blood pressure (e.g., phenylephrine, pseudoephedrine, ephedrine, thyroid hormones) or with MAO inhibitors and linezolid. Caution is advised when taken with cardiac glycosides (like digoxin) or beta-blockers, as it may slow the heart rate. Alpha-blockers (such as prazosin or terazosin) may also interact, potentially causing an excessive drop in blood pressure.

What precautions should be taken while on MIDODRIVE 2.5 MG TABLET?

Regular monitoring of blood pressure, especially when lying down and standing, is crucial to detect and manage potential supine hypertension (high blood pressure while lying flat). You should not lie down for extended periods immediately after taking a dose. This medication is not recommended for individuals under 18 years of age. It is contraindicated in patients with severe heart disease, severe kidney disease, high blood pressure (especially supine hypertension), urinary retention, narrow-angle glaucoma, an overactive thyroid, or pheochromocytoma. Exercise caution if you have liver problems, diabetes, or a history of visual issues. Alcohol consumption should be limited or avoided as it may worsen side effects. If you experience dizziness or lightheadedness, avoid driving or operating heavy machinery.

What happens if a dose of MIDODRIVE 2.5 MG TABLET is missed?

If you miss a dose of MIDODRIVE 2.5 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. You might also need to skip a dose if you anticipate lying down or resting for a prolonged period during your normal waking hours.

How should MIDODRIVE 2.5 MG TABLET be stored?

MIDODRIVE 2.5 MG TABLET should be stored in a cool, dry place at room temperature (below 30°C or between 15°C to 30°C). Keep the tablets in their original packaging, tightly closed, and protect them from light and moisture. Always ensure this medication is kept out of the sight and reach of children and pets.