Oxramet G Xr 10/1/500

OXRAMET G XR 10/1/500 Tablet is an anti-diabetic medication manufactured by Sun Pharmaceutical Industries Ltd..

Composition

OXRAMET G XR 10/1/500 contains a fixed-dose combination of three active ingredients:

• Dapagliflozin (10 mg), a sodium-glucose cotransporter-2 (SGLT2) inhibitor.
• Glimepiride (1 mg), a sulfonylurea.
• Metformin (500 mg), a biguanide.

Uses

This medication is primarily used for the management of Type 2 Diabetes Mellitus in adults to control high blood sugar levels, especially when lifestyle changes and dual therapy are insufficient. It works by increasing insulin secretion, improving the body's response to insulin, reducing glucose production in the liver, delaying sugar absorption from the intestines, and increasing the elimination of excess glucose through urine.

Dosage and Administration

OXRAMET G XR 10/1/500 is typically taken once daily as prescribed by a doctor, preferably with meals to minimize stomach upset and maximize absorption. The tablet should be swallowed whole with water and not crushed, chewed, or broken. The exact dosage is determined by a healthcare professional.

Side Effects

Common side effects include low blood sugar (hypoglycemia), nausea, vomiting, abdominal pain, headache, dizziness, asthenia, constipation, sore throat, muscle pain, genital infections, back pain, increased urination, and weight gain. Serious side effects, though rare, can include lactic acidosis, severe urinary tract infections, and severe allergic reactions.

Precautions

OXRAMET G XR 10/1/500 is contraindicated in individuals with severe kidney problems, liver disease, diabetic ketoacidosis, bladder cancer, severe heart failure, severe low blood pressure, or severe dehydration. Caution is advised with alcohol consumption as it may increase the risk of hypoglycemia and lactic acidosis. It is generally not recommended during pregnancy or breastfeeding, and caution is advised for elderly patients and children under 18 years of age. Inform your doctor about all current medications, including herbal supplements, to avoid potential drug interactions.

Storage

Store OXRAMET G XR 10/1/500 in a cool and dry place, away from direct sunlight and moisture, typically at room temperature (between 10ºC to 25ºC or below 30ºC). Keep out of the sight and reach of children.

What is OXRAMET G XR 10/1/500 used for?

OXRAMET G XR 10/1/500 is a combination medication primarily used for the management of Type 2 Diabetes Mellitus in adults. It helps to control high blood sugar levels, especially when diet and exercise alone, or dual therapy, are not sufficient. This can help reduce the chances of serious complications associated with diabetes and may also reduce the risk of heart disease.

How does OXRAMET G XR 10/1/500 work?

This medicine contains three active ingredients: Dapagliflozin, Glimepiride, and Metformin, each working through different mechanisms to help control blood sugar.

• Dapagliflozin (an SGLT2 inhibitor) works by blocking specific proteins in the kidneys (SGLT2 receptors), which increases the excretion of excess glucose from the body through urine.
• Glimepiride (a sulfonylurea) stimulates the beta cells in the pancreas to release more insulin, a hormone that helps move glucose from the bloodstream into cells.
• Metformin (a biguanide) primarily reduces the amount of glucose produced by the liver, improves the body's sensitivity to insulin, and slows down the absorption of glucose from the intestines.

What is the usual dosage for OXRAMET G XR 10/1/500?

OXRAMET G XR 10/1/500 is typically taken once daily, with or without food, as prescribed by your doctor. It's important to swallow the tablet whole and not to crush, chew, or break it, as this can affect its extended-release mechanism. Always follow your doctor's instructions carefully and do not exceed the recommended dose.

What are the possible side effects of OXRAMET G XR 10/1/500?

Common side effects may include low blood sugar (hypoglycemia), nausea, vomiting, abdominal pain, diarrhea, headache, dizziness, weight gain (due to Glimepiride), urinary tract infections (UTIs), genital infections, constipation, sore throat, muscle pain, and increased urination. Serious but less common side effects can include lactic acidosis (a rare but life-threatening condition associated with metformin), severe UTIs, or allergic reactions. Seek immediate medical attention if you experience severe side effects.

Is OXRAMET G XR 10/1/500 safe during pregnancy or breastfeeding?

Pregnancy: OXRAMET G XR 10/1/500 may not be safe for use during pregnancy, and there is limited information on its effects. It is crucial to consult your doctor if you are pregnant or planning to conceive before taking this medication. Breastfeeding: It is generally not recommended to use OXRAMET G XR 10/1/500 while breastfeeding as the safety of this combination during lactation is not well established. Always consult your doctor for advice if you are breastfeeding.

Can OXRAMET G XR 10/1/500 be taken with other medications?

Yes, OXRAMET G XR 10/1/500 can interact with other medications. It is essential to inform your doctor about all medicines, supplements, or herbal products you are currently taking or plan to take to avoid potential drug interactions.

• Taking it with diuretics (e.g., furosemide, hydrochlorothiazide) may increase the risk of dehydration and low blood pressure.
• Concomitant use with insulin or other insulin secretagogues (e.g., other sulfonylureas) can significantly increase the risk of very low blood sugar levels (hypoglycemia).
• Beta-blockers may mask the symptoms of hypoglycemia.
• Corticosteroids may reduce the blood glucose-lowering effect of OXRAMET G XR.
• It should not be used if you are undergoing X-ray procedures involving certain iodinated contrast agents.
• Carbonic anhydrase inhibitors may increase the risk of lactic acidosis when taken with metformin.

What precautions should be taken while taking OXRAMET G XR 10/1/500?

This medicine is not indicated for Type 1 diabetes. Inform your doctor if you have any history of kidney disease, liver disease, heart problems, or excessive alcohol consumption. Caution is advised for elderly patients, as they may be more susceptible to certain side effects. Avoid excessive alcohol intake, as it can increase the risk of hypoglycemia and a serious condition called lactic acidosis. Regular monitoring of your blood sugar levels, kidney function, and liver function is necessary during treatment. Stay well-hydrated to prevent dehydration and maintain good hygiene to prevent genital infections. Do not stop taking the medicine without consulting your doctor. Your ability to drive or operate machinery may be affected if your blood sugar levels are too low or too high.

What happens if a dose of OXRAMET G XR 10/1/500 is missed?

If you miss a dose of OXRAMET G XR 10/1/500, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should OXRAMET G XR 10/1/500 be stored?

Store OXRAMET G XR 10/1/500 at room temperature, typically between 20-25°C (or below 30°C), away from moisture, heat, and direct sunlight. Always keep this medicine out of the sight and reach of children.