ACTOID 25 MG CAPSULE

ACTOID 25 MG CAPSULE is a prescription medication manufactured by INTAS PHARMACEUTICALS LTD., primarily used for severe skin conditions.

• Name:

  • Brand Name: ACTOID 25 MG CAPSULE
  • Common Name: Acitretin 25 mg Capsule

• Composition:

  • Active Ingredient: Acitretin 25 mg. Acitretin is a synthetic retinoid, a derivative of vitamin A, known for its anti-inflammatory and antiproliferative properties.

• Uses: ACTOID 25 MG CAPSULE is primarily prescribed for the management of severe or extensive skin problems that have not responded to other treatments. It helps to normalize the growth and shedding of skin cells.

  • Psoriasis: A chronic autoimmune skin condition characterized by red, scaly patches on the skin.
  • Ichthyosis: A group of genetic skin disorders causing dry, thickened, scaly skin.
  • Keratosis Follicularis (Darier's Disease): A rare inherited skin condition with crusted or scaly spots.
  • Pityriasis: Skin rashes appearing as large spots.
  • Lichen Planus: Itchy, non-infectious rashes on arms and legs.

• Dosage and Administration: ACTOID 25 MG CAPSULE should be taken exactly as prescribed by your doctor, usually once daily, preferably with meals or a glass of milk. The capsule should be swallowed whole and not crushed, chewed, or broken. The typical starting dose for adults is 25 to 50 mg once daily, and the doctor may adjust the dose based on the patient's response, with a maximum recommended daily dose of 75 mg. Do not discontinue the medicine prematurely without consulting your doctor.

• Side Effects: Common side effects may include:

  • Dry lips, dry mouth, and skin peeling (especially palms and soles).
  • Hair loss.
  • Nosebleeds and nasal inflammation.
  • Itching, burning sensation, and reddening of the skin.
  • Eye irritation, dry eyes, and vision problems (especially at night).
  • Joint pain (arthralgia) and muscle pain (myalgia).
  • Elevated blood fat levels. Serious side effects, though less common, can include severe headache, nausea, vomiting, liver damage (yellowing of skin/eyes, dark urine, upper right stomach pain), and mood changes (depression, aggressive behavior).

• Precautions:

  • Pregnancy and Breastfeeding: ACTOID 25 MG CAPSULE is highly contraindicated during pregnancy due to the risk of severe birth defects and should not be used by breastfeeding women. Women of childbearing potential must use effective contraception during treatment and for three years after discontinuing the medicine.
  • Alcohol: Avoid alcohol consumption during treatment and for two months after stopping, as it can increase the risk of side effects and form a long-acting teratogenic metabolite.
  • Drug Interactions: Inform your doctor about all other medications, especially tetracycline antibiotics, methotrexate, progestin-only contraceptives, other retinoids (e.g., isotretinoin, tazarotene), and vitamin A supplements, as interactions can occur.
  • Medical Conditions: Use with caution in patients with liver or kidney impairment, high cholesterol, and diabetes, as it can alter blood glucose levels.
  • Sun Sensitivity: This medicine can increase skin sensitivity to sunlight; avoid strong sunlight and use protective clothing and sunscreen.
  • Driving and Machinery: May cause dizziness, sleepiness, and vision problems, especially at night. Avoid driving or operating heavy machinery until you know how it affects you.
  • Contact Lenses: May cause dry eyes; avoid wearing contact lenses during treatment.

• Storage: Store ACTOID 25 MG CAPSULE in a cool, dry place below 30°C, protected from direct sunlight and moisture. Keep it out of reach of children and pets.

ACTOID 25 MG CAPSULE (10 CAP) by INTAS PHARMACEUTICALS LTD. - Frequently Asked Questions

What is ACTOID 25 MG CAPSULE used for?

ACTOID 25 MG CAPSULE is primarily used to treat severe psoriasis, an autoimmune skin disorder characterized by red, scaly, swollen, and itchy patches on the skin. It is also used to manage other skin disorders involving abnormal keratinization, such as ichthyosis and Darier's disease, where there is excessive growth and hardening of skin cells. This medication is typically prescribed when other conventional therapies have not been effective.

How does ACTOID 25 MG CAPSULE work?

ACTOID 25 MG CAPSULE contains Acitretin, a retinoid derived from vitamin A. It works by slowing down the excessive growth and thickening of skin cells, which is a hallmark of psoriasis. By influencing skin cell growth and maturation (differentiation), it helps to normalize keratinization, reduce inflammation, and clear affected skin, thereby reducing redness, scaling, and thickness of psoriasis rashes.

What is the usual dosage for ACTOID 25 MG CAPSULE?

The usual starting dose for adults is typically 25 to 50 milligrams (mg) once daily. Your doctor will determine the appropriate dose and duration of treatment based on your specific condition and how you respond to the medication. It is generally recommended to take ACTOID 25 MG CAPSULE once daily with meals or a glass of milk. Do not crush, chew, or break the capsule, and swallow it whole with water. The maximum recommended daily dose is typically 75 mg.

What are the possible side effects of ACTOID 25 MG CAPSULE?

Common side effects may include dry lips, peeling of the skin (especially on palms and soles), nosebleeds, thinning of healthy skin, reddening of the skin, itching, burning sensation on the skin, sticky skin, hair loss, swelling and pain around nails, fragile nails, eye inflammation (conjunctivitis), increased thirst, and feeling cold. Other possible side effects include dry mouth, joint pain, runny nose, and increased levels of blood fat. These side effects often subside after discontinuing the treatment. If any side effects persist or worsen, inform your doctor immediately.

Is ACTOID 25 MG CAPSULE safe during pregnancy or breastfeeding?

No, ACTOID 25 MG CAPSULE is highly unsafe and contraindicated for use during pregnancy as it can cause serious birth defects. Women who are capable of becoming pregnant must use two effective and reliable forms of contraception (e.g., an intrauterine device, contraceptive implant, or contraceptive pill and condom) starting at least one month before treatment, during treatment, and for at least three years after discontinuing the medication. You should also undergo regular pregnancy tests. It is also contraindicated for breastfeeding women as it may pass into breast milk and harm the nursing baby.

Can ACTOID 25 MG CAPSULE be taken with other medications?

ACTOID 25 MG CAPSULE can interact with certain medications. It should not be taken with tetracycline antibiotics (which can increase the risk of a condition called pseudotumor cerebri) or methotrexate (used for cancer, psoriasis, and rheumatoid arthritis). Taking it with vitamin A supplements or other retinoid medicines (like isotretinoin or tazarotene) can lead to increased toxicity and side effects. The effectiveness of low-dose progesterone-only contraceptive pills may also be reduced. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid possible interactions.

What precautions should be taken with ACTOID 25 MG CAPSULE?

Several precautions should be taken:

• Alcohol: Avoid alcohol consumption during treatment and for two months after, as it can increase the risk of side effects.
• Driving and Vision: This medicine may cause vision problems, especially in the dark, and can affect alertness, so avoid driving or operating heavy machinery if you experience these effects.
• Sunlight: ACTOID 25 MG CAPSULE can increase skin sensitivity to sunlight, so avoid strong sunlight and sunbeds, and use protective measures like sunscreen and clothing.
• Contact Lenses: Avoid wearing contact lenses as it may cause dry eyes.
• Liver and Kidney: Use with caution if you have liver or kidney problems; dose adjustments may be needed. Regular monitoring of liver function and blood fat levels may be recommended.
• Mental Health: Inform your doctor if you have mental health problems like depression or notice drastic mood changes.
• Blood Donation: Do not donate blood during treatment and for at least three years after discontinuing the medicine, as it could harm a pregnant recipient.
• Diabetes: Use with caution in patients with diabetes as it can alter blood glucose levels.

What happens if a dose is missed?

If you miss a dose of ACTOID 25 MG CAPSULE, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should ACTOID 25 MG CAPSULE be stored?

Store ACTOID 25 MG CAPSULE below 30°C in a cool and dry place, away from direct sunlight and moisture. Keep the medicine out of reach of children and pets.