Stalix Dm (10/100/1000) Tab

STALIX DM (10/100/1000) Tablet

STALIX DM 10/100/1000 Tablet, also known as STALIX DM, is a combination medication manufactured by Torrent Pharmaceuticals Ltd. (FORZA) used for the management of type 2 diabetes mellitus.

Composition Each tablet contains three active ingredients:

• Dapagliflozin: 10 mg
• Sitagliptin: 100 mg
• Metformin: 1000 mg

Uses STALIX DM is prescribed to improve blood sugar control in adults with type 2 diabetes mellitus when diet and exercise alone are insufficient. It works by increasing insulin secretion, decreasing glucagon production, improving the body's response to insulin, reducing glucose production in the liver, and promoting glucose excretion through the kidneys.

Dosage and Administration STALIX DM is typically taken once or twice daily, preferably with meals to minimize gastrointestinal side effects. The tablet should be swallowed whole and not chewed, crushed, or broken. It is important to take the medicine at a fixed time each day as advised by your doctor, and not to alter the dosage or discontinue without consulting a healthcare provider.

Side Effects Common side effects may include:

• Nausea
• Diarrhea
• Stomach upset/abdominal pain
• Headache
• Urinary tract infections (UTIs)
• Genital fungal infections
• Nasopharyngitis (inflammation of the throat and nasal passages)

Serious, though rare, side effects can include lactic acidosis (a buildup of lactic acid in the blood) or kidney problems. Patients should seek immediate medical attention if they experience severe or persistent side effects, or symptoms such as weakness, breathing difficulty, or severe stomach pain.

Precautions Before starting STALIX DM, inform your doctor about any existing medical conditions, especially kidney or liver disease, heart failure, or a history of pancreatitis. Pregnant or breastfeeding women should consult their doctor before using this medication. Alcohol consumption should be limited as it can increase the risk of hypoglycemia (low blood sugar) and lactic acidosis. Regular monitoring of blood sugar levels and kidney function is essential during treatment. This medicine is not recommended for children below 18 years of age.

Storage Store STALIX DM in a cool, dry place, away from direct sunlight and moisture. Keep the medication out of reach of children.

STALIX DM (10/100/1000) Tablet is a combination medication containing Dapagliflozin (10 mg), Sitagliptin (100 mg), and Metformin (1000 mg). It is manufactured by Torrent Pharma Ltd and is used for managing type 2 diabetes mellitus.

What is STALIX DM used for?

STALIX DM (10/100/1000) Tablet is used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels when diet and exercise alone are not sufficient. This medication can help prevent long-term complications associated with diabetes, such as kidney damage, eye damage, nerve problems, and loss of limbs, and may also reduce the risk of death from cardiovascular disease in type 2 diabetes patients with cardiovascular disease.

How does STALIX DM work?

STALIX DM works through the combined action of its three active ingredients:

• Sitagliptin (a DPP-4 inhibitor) increases the release of insulin from the pancreas and decreases hormones that raise blood sugar levels, especially when blood sugar is high.
• Dapagliflozin (an SGLT2 inhibitor) blocks the reabsorption of glucose in the kidneys, leading to the excretion of excess glucose in the urine and thus lowering blood glucose levels.
• Metformin (a biguanide) decreases glucose production in the liver, improves the body's sensitivity to insulin, and delays sugar absorption from the intestines.

What is the usual dosage for STALIX DM?

The recommended dosage of STALIX DM (10/100/1000) is individualized by your doctor based on factors such as the severity of your diabetes, blood glucose levels, and kidney function. It is crucial to strictly follow the dosage prescribed by your physician. Typically, STALIX DM is taken once or twice daily, often with meals to minimize gastrointestinal side effects. Do not alter the dosage or stop taking the medication without consulting your healthcare provider.

What are the possible side effects of STALIX DM?

Common side effects of STALIX DM may include nausea, diarrhea, stomach upset, headache, urinary tract infections, nasal congestion, sore throat, and upper respiratory tract infections. Some individuals might also experience fungal infections in the genital area. In rare cases, more serious side effects such as lactic acidosis (a buildup of lactic acid in the blood) or kidney problems can occur. You should contact your doctor immediately if you experience any severe or persistent side effects.

Is STALIX DM safe during pregnancy or breastfeeding?

There is limited information on the effect of STALIX DM during pregnancy, and therefore, it should not be used during pregnancy. Similarly, no information is available if STALIX DM passes into human breast milk, so it should not be used by breastfeeding women. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medication.

Can STALIX DM be taken with other medications?

STALIX DM can interact with several other medications. It is important to inform your doctor about all other medications, supplements, and herbal products you are taking.

• Using STALIX DM with insulin or other anti-diabetic medicines like sulfonylureas may cause extremely low blood sugar levels (hypoglycemia).
• Diuretics (water pills) such as furosemide or hydrochlorothiazide can increase the risk of dehydration and low blood pressure.
• Carbonic anhydrase inhibitors (e.g., acetazolamide) may increase the risk of lactic acidosis.
• Certain antibiotics (e.g., clarithromycin), antifungals (e.g., ketoconazole), and HIV/AIDS medicines (e.g., ritonavir) may also interact.
• Cationic medications like digoxin, morphine, and vancomycin may reduce metformin elimination.

What precautions should be taken with STALIX DM?

• Kidney and Liver Disease: STALIX DM is not recommended for individuals with severe kidney or liver impairment due to potential risks associated with its components. Caution is advised in less severe cases.
• Hydration: Stay well-hydrated by drinking plenty of water throughout the day to help prevent kidney problems and dehydration.
• Alcohol: Avoid excessive alcohol consumption as it can interact with the medication, increasing the risk of hypoglycemia (low blood sugar) or lactic acidosis.
• Pancreatitis: Inform your doctor if you have a history of pancreatitis or risk factors for it.
• Monitoring: Regular monitoring of blood sugar levels is essential to ensure the medication is working effectively.
• Diet and Exercise: This medicine is most effective when combined with a healthy diet and regular physical activity.
• Allergies: Do not take STALIX DM if you are allergic to sitagliptin, dapagliflozin, metformin, or any other ingredient in the tablet.

What happens if a dose is missed?

If you miss a dose of STALIX DM, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed dose. Missing doses frequently can lead to increased blood sugar levels and potential complications. If you frequently miss doses or have concerns, contact your doctor.

How should STALIX DM be stored?

STALIX DM should be stored at room temperature, ideally below 30°C (86°F), away from moisture, humidity, and direct sunlight. Keep the medication in a tightly sealed container and out of reach of children and pets.