Justoza Sm 1000mg Tab

JUSTOZA SM 1000MG Tablet

Name

• Brand Name: JUSTOZA SM 1000MG
• Common Name: Dapagliflozin, Metformin, and Sitagliptin combination tablet

Composition

JUSTOZA SM 1000MG Tablet is a fixed-dose combination medication containing three active ingredients:

• Dapagliflozin: 10 mg
• Metformin: 1000 mg
• Sitagliptin: 100 mg

Uses

JUSTOZA SM 1000MG Tablet is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and therapy with conventional medicines do not result in an adequate response. It aims to improve blood sugar control and is also an adjunct to diet and exercise for better glycemic control. This medication assists patients requiring enhanced blood sugar management beyond dual therapy. It is not intended for managing type 1 diabetes or diabetic ketoacidosis.

Dosage and Administration

Take JUSTOZA SM 1000MG Tablet as prescribed by your healthcare provider. It can be taken with or without food, but taking it with meals may help reduce gastrointestinal side effects. The tablet should be swallowed whole with water, without chewing or crushing. For optimal benefits, it is recommended to take the medicine consistently at the same time each day. Do not stop taking the medication without consulting your doctor.

Side Effects

Common Side Effects:

• Female genital mycotic infections
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Urinary tract infections (UTIs)
• Diarrhea
• Headache
• Nausea
• Vomiting
• Hypoglycemia (low blood glucose level)
• Flatulence
• Increased or more frequent urination
• Drowsiness, dizziness
• Stomach pain
• Itching
• Dry mouth
• Decreased weight
• Thirst

Serious Side Effects: Seek immediate medical attention if you experience symptoms of acute pancreatitis (severe, persistent abdominal pain), allergic reactions (rash, hives, swelling of face, lips, tongue, throat), bullous pemphigoid (blistering skin), lactic acidosis (weakness, breathing difficulty, stomach pain), or ketoacidosis (nausea, vomiting, confusion, fruity breath).

Precautions

• Allergies: Do not use if allergic to dapagliflozin, metformin, sitagliptin, or any other ingredients.
• Pregnancy and Breastfeeding: Not recommended during pregnancy or for breastfeeding women; consult a doctor.
• Kidney/Liver Impairment: Use with caution in patients with kidney disease; not recommended for severe renal impairment or those on dialysis due to the metformin component. Avoid in severe liver disease.
• Alcohol: Limit alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis.
• Elderly Patients: Special precautions and close monitoring of renal function and blood sugar levels may be required.
• Children: Not recommended for use in children below 18 years of age.
• Dehydration: Drinking plenty of fluids is essential to prevent dehydration.
• Interactions:
  • Drug-Drug: May interact with thiazide and loop diuretics (e.g., hydrochlorothiazide, furosemide), carbonic anhydrase inhibitors (e.g., acetazolamide), insulin, sulfonylureas, beta-blockers, ketoconazole, itraconazole, ritonavir, clarithromycin, corticosteroids, and certain heart medicines (e.g., captopril, enalapril).
  • Drug-Disease: Contraindicated in severe renal impairment, severe liver disease, heart failure, type 1 diabetes, metabolic acidosis, or diabetic ketoacidosis.
• Driving: May cause dizziness or sleepiness; avoid driving or operating machinery if affected.

Storage

Store JUSTOZA SM 1000MG Tablet in a cool, dry place away from direct sunlight, below 30°C. Keep out of the sight and reach of children.

Here are frequently asked questions about JUSTOZA SM 1000MG TAB by MANKIND PHARMA LTD.

What is JUSTOZA SM 1000MG TAB used for?

JUSTOZA SM 1000MG TAB is primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and other conventional diabetes medicines do not adequately control blood sugar levels. This medication works as an adjunct to diet and exercise to improve glycemic control and can also help lower the risk of heart failure and diabetic kidney disease in some individuals with type 2 diabetes.

How does JUSTOZA SM 1000MG TAB work?

This medicine is a combination of three active ingredients: Dapagliflozin (10 mg), Metformin (1000 mg), and Sitagliptin (100 mg). Each component works differently to help control blood sugar:

• Dapagliflozin: An SGLT2 inhibitor that reduces glucose reabsorption in the kidneys, leading to increased glucose excretion in the urine.
• Metformin: A biguanide that decreases glucose production by the liver, reduces glucose absorption from the intestines, and improves the body's sensitivity to insulin.
• Sitagliptin: A DPP-4 inhibitor that slows the inactivation of incretin hormones, which helps increase insulin production and decrease glucagon secretion when blood sugar levels are high.

What is the usual dosage of JUSTOZA SM 1000MG TAB?

The dosage of JUSTOZA SM 1000MG TAB is determined by your doctor, considering your individual health condition and response to the medicine. It should be taken exactly as prescribed, usually with or without food, and ideally at the same time each day to maintain consistent blood sugar control. You should never alter the prescribed dose or stop taking the medication without consulting your doctor.

What are the possible side effects of JUSTOZA SM 1000MG TAB?

Common side effects include female genital mycotic infections, urinary tract infections (UTIs), nasopharyngitis (sore throat, nasal congestion), diarrhea, headache, nausea, and vomiting. Other potential side effects may include hypoglycemia (low blood sugar), flatulence, drowsiness, dizziness, stomach pain, and decreased weight. Serious but rare side effects like lactic acidosis, ketoacidosis, acute pancreatitis, or severe allergic reactions require immediate medical attention.

Is JUSTOZA SM 1000MG TAB safe during pregnancy or breastfeeding?

JUSTOZA SM 1000MG TAB is generally not recommended during pregnancy or breastfeeding. There is limited information on its effects during pregnancy, and its components may pose risks to the fetus or pass into breast milk. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding before taking this medication.

Can JUSTOZA SM 1000MG TAB be taken with other medications?

Yes, JUSTOZA SM 1000MG TAB can interact with other medications. It is crucial to inform your doctor about all prescription, over-the-counter, herbal supplements, and other medicines you are currently taking. Particular care should be taken if you are also on diuretics (water pills), other antidiabetic medicines (like sulfonylureas or insulin), certain antifungal medications (e.g., ketoconazole), some antibiotics (e.g., clarithromycin), or corticosteroids, as these can increase the risk of side effects or alter blood sugar control.

What precautions should be taken while using JUSTOZA SM 1000MG TAB?

• Not for Type 1 Diabetes: This medicine is only for adults with type 2 diabetes and should not be used for type 1 diabetes or diabetic ketoacidosis.
• Alcohol: Limit or avoid alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis.
• Kidney/Liver Issues: Exercise caution or avoid if you have severe kidney or liver impairment.
• Hydration: Drink plenty of fluids to prevent dehydration, especially due to dapagliflozin's effect on urine.
• Hygiene: Maintain good genital hygiene to prevent fungal infections.
• Discontinuation: Do not stop taking the medicine abruptly, as this can lead to increased blood sugar levels and complications.
• Dizziness: It may cause dizziness or sleepiness; be cautious when driving or operating machinery.
• Monitoring: Regular monitoring of blood sugar levels and kidney function is essential.

What happens if a dose of JUSTOZA SM 1000MG TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should JUSTOZA SM 1000MG TAB be stored?

Store JUSTOZA SM 1000MG TAB in a cool, dry place, away from direct sunlight, and below 30°C (or between 10°C to 25°C). Keep it in a tightly sealed container and out of the sight and reach of children. Do not use the medication past its expiration date.