Syncapone 100 Mg Tablet (10 Tab)

SYNCAPONE 100 MG TABLET

SYNCAPONE 100 MG TABLET, manufactured by Sun Pharma Laboratories Ltd., is a combination medicine used to manage the symptoms of Parkinson's disease.

• Composition: Each tablet contains Levodopa (100 mg), Carbidopa (25 mg), and Entacapone (200 mg).

  • Levodopa is converted to dopamine in the brain, helping to control movement.
  • Carbidopa prevents the breakdown of levodopa in the bloodstream, allowing more of it to reach the brain.
  • Entacapone extends the effect of levodopa by inhibiting its breakdown.

• Uses: This medication is prescribed for adult patients with Parkinson's disease to alleviate symptoms such as muscle stiffness, tremors, muscle spasms, poor muscle control, and slowness of movement. It is also used to address "end-of-dose" motor fluctuations where the effects of levodopa/carbidopa alone wear off before the next dose.

• Dosage and Administration: SYNCAPONE 100 MG TABLET is taken orally, typically as one tablet per dose. The optimum daily dose is determined by a doctor through careful titration. It can be taken with or without food, though a high-protein diet may reduce levodopa absorption. Patients should not stop taking this medicine suddenly without consulting their doctor. It is not recommended for individuals under 18 years of age.

• Side Effects:

  • Common: Uncontrolled body movements (dyskinesia), nausea, diarrhea, reddish-brown discoloration of urine, headache, dry mouth, insomnia, anxiety, abnormal dreams, dizziness, drowsiness, stomach pain, and muscle pain.
  • Serious: Severe muscle pain, confusion, high fever, hallucinations, suicidal thoughts, severe diarrhea, or signs of muscle breakdown (dark urine).

• Precautions: Alcohol consumption is not recommended due to increased risk of severe adverse effects like confusion and dizziness. Caution is advised when driving or operating machinery as the medicine can cause dizziness and sleepiness. It is generally not recommended for pregnant or breastfeeding women. Patients with severe liver or kidney disease, narrow-angle glaucoma, a history of melanoma, cardiovascular disease, or peptic ulcers should use this medicine with caution and under medical supervision. Inform your doctor about all other medicines being taken to avoid potential interactions.

• Storage: Store SYNCAPONE 100 MG TABLET at a temperature below 30°C. Keep it out of the reach of children and pets.

What is SYNCAPONE 100 MG TABLET used for?

SYNCAPONE 100 MG TABLET is primarily used to treat the symptoms of Parkinson's disease, a neurological disorder that affects movement. These symptoms can include tremors, muscle stiffness, muscle spasms, poor muscle control, and slowness of movement. It helps to control movement and offers relief from these symptoms, thereby enhancing the quality of life for individuals with the condition.

How does SYNCAPONE 100 MG TABLET work?

SYNCAPONE 100 MG TABLET is a combination of three medicines: Levodopa, Carbidopa, and Entacapone. Levodopa is converted into dopamine in the brain, a chemical messenger vital for controlling movement, which is deficient in Parkinson's patients. Carbidopa works by preventing the breakdown of Levodopa in the bloodstream, allowing more Levodopa to reach the brain effectively. Entacapone further enhances this effect by inhibiting an enzyme (COMT) that breaks down Levodopa, leading to higher and more sustained levels of Levodopa in the blood and brain, providing greater symptom relief.

What is the usual dosage for SYNCAPONE 100 MG TABLET?

The dosage of SYNCAPONE 100 MG TABLET, which contains 100 mg Levodopa, 25 mg Carbidopa, and 200 mg Entacapone, is determined by your doctor based on your medical condition and response to treatment. It is generally taken orally, either with or without food, though it is recommended to take it with a low-protein meal for optimal absorption. Patients are typically instructed to take only one tablet per dose administration, and the maximum recommended daily dose of entacapone across various strengths is 2,000 mg. It's important to take it at the same time each day to maintain consistent levels in the body.

What are the possible side effects of SYNCAPONE 100 MG TABLET?

Common side effects may include nausea, vomiting, loss of appetite, light-headedness, lowered blood pressure, confusion, dyskinesia (uncontrolled/involuntary muscle movement), diarrhea, urine discoloration, headache, dry mouth, and sleep disturbances. More serious side effects can include severe muscle pain, hallucinations, suicidal thoughts, and signs of muscle breakdown such as dark urine, which require immediate medical attention.

Is SYNCAPONE 100 MG TABLET safe during pregnancy or breastfeeding?

SYNCAPONE 100 MG TABLET should be used with caution during pregnancy and is generally not recommended unless absolutely necessary, as animal studies have shown potential adverse effects on the fetus, and there are limited human studies. For breastfeeding women, it is probably unsafe, and a doctor should be consulted to discuss the potential risks and benefits, as the medication is excreted in human milk, and its effect on an infant is unknown.

Can SYNCAPONE 100 MG TABLET be taken with other medications?

There are several potential drug interactions with SYNCAPONE 100 MG TABLET. It should not be taken with non-selective monoamine oxidase inhibitors (MAOIs) due to the increased risk of severe interactions, and MAOIs should be stopped at least 14 days before starting Syncapone. Caution is advised with iron preparations, as they may reduce Levodopa's effectiveness; these should be administered 2 to 3 hours apart. Antipsychotics like haloperidol or risperidone, methyldopa, and metoclopramide may also interact and should be used cautiously or avoided. Always inform your doctor about all medications, supplements, and herbal products you are currently taking.

What precautions should be taken while taking SYNCAPONE 100 MG TABLET?

Avoid or limit alcohol consumption while taking this medication as it can worsen side effects such as drowsiness and dizziness. High-protein foods can reduce the absorption of Levodopa, so it's recommended to take the medication with a low-protein meal or avoid high-protein dairy products. Use with caution if you have a history of liver or kidney diseases, cardiovascular disease, peptic ulcers, glaucoma, hypotension, or depression. This medicine can cause sudden dizziness and sleepiness, so avoid driving or operating machinery until you know how it affects you. Do not stop taking SYNCAPONE 100 MG TABLET suddenly without consulting your doctor, as abrupt discontinuation can lead to worsening symptoms or withdrawal effects.

What happens if a dose of SYNCAPONE 100 MG TABLET is missed?

If you miss a dose of SYNCAPONE 100 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should SYNCAPONE 100 MG TABLET be stored?

SYNCAPONE 100 MG TABLET should be stored at room temperature, typically below 30°C. Keep it in a cool, dry place, protected from moisture and light, and out of the sight and reach of children and pets.