Ivabid-7.5 Tab

IVABID-7.5 TAB

IVABID-7.5 TAB, manufactured by Abbott Healthcare Pvt. Ltd., is a medication primarily used for specific cardiac conditions.

Name

• Common Name: Ivabradine
• Brand Name: IVABID-7.5 TAB (also known by other brand names like Procoralan or Corlanor in different regions)

Composition Each film-coated tablet contains 7.5 mg of Ivabradine as the active ingredient.

Uses IVABID-7.5 TAB is prescribed for adults with certain heart conditions:

• Chronic Stable Angina Pectoris: For the symptomatic treatment of chronic stable angina (chest pain) in adults with coronary artery disease who have a normal sinus rhythm and a resting heart rate of 70 beats per minute (bpm) or higher. It is used when beta-blockers cannot be tolerated, are contraindicated, or do not adequately control the condition.
• Chronic Heart Failure: Used in adult patients with stable, symptomatic chronic heart failure, a reduced left ventricular ejection fraction (≤35%), a normal sinus rhythm, and a resting heart rate of 70 bpm or higher (or ≥75 bpm as per some guidelines). It is used in combination with standard therapy, including beta-blockers, or when beta-blockers are contraindicated or not tolerated.
• It also helps to reduce the risk of hospitalization for worsening heart failure.

Dosage and Administration

• IVABID-7.5 TAB should be taken orally twice daily, typically once in the morning and once in the evening, during meals.
• The usual recommended starting dose of ivabradine is often 5 mg twice daily. The dose can be adjusted after two weeks based on the patient's resting heart rate and tolerability. The maximum maintenance dose should not exceed 7.5 mg twice daily.
• For patients aged 75 years or older, a lower starting dose (e.g., 2.5 mg twice daily) may be considered.
• If the resting heart rate persistently falls below 50 bpm or symptoms related to bradycardia (e.g., dizziness, fatigue, hypotension) occur, the dose should be reduced. Treatment should be discontinued if the heart rate remains below 50 bpm or if bradycardia symptoms persist.

Side Effects

• Very Common (more than 1 in 10 people): Luminous visual phenomena (phosphenes), described as temporary brightness, halos, or colored flashes, usually occurring within the first two months of treatment.
• Common (up to 1 in 10 people): Slowing of the heart rate (bradycardia), irregular rapid heart contractions (atrial fibrillation), headaches, dizziness, blurred vision, and uncontrolled blood pressure.
• Uncommon (up to 1 in 100 people): Palpitations, nausea, constipation, diarrhea, abdominal pain, vertigo, difficulty breathing, muscle cramps, changes in laboratory parameters (e.g., high uric acid, elevated creatinine), skin rash, angioedema, low blood pressure, fainting, tiredness, and abnormal ECG readings.

Precautions

• IVABID-7.5 TAB is contraindicated in patients with acute decompensated heart failure, clinically significant hypotension (blood pressure <90/50 mmHg), severe hepatic insufficiency, sick sinus syndrome, sinoatrial block, or 3rd-degree AV block unless a functioning demand pacemaker is present. It should not be initiated if the pre-treatment resting heart rate is below 70 bpm.
• Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir, nefazodone) and certain calcium channel blockers (e.g., diltiazem, verapamil) is contraindicated due to an increased risk of excessive bradycardia.
• Avoid grapefruit juice consumption as it can increase the drug's exposure.
• Patients should be monitored for the development of atrial fibrillation and symptoms of bradycardia during treatment.
• Due to potential temporary visual disturbances, caution is advised when driving or operating machinery, especially in situations with sudden changes in light intensity or when driving at night.
• This medicine is not recommended during pregnancy or breastfeeding. Females of childbearing potential should use effective contraception.

Storage Store IVABID-7.5 TAB in a closed container at room temperature, ideally below 25°C or 30°C, away from heat, moisture, and direct light. Keep it in the original package to protect from moisture and do not freeze. Keep out of sight and reach of children.

Here are some frequently asked questions about IVABID-7.5 TAB (Ivabradine 7.5mg) along with their concise answers:

What is IVABID-7.5 TAB used for?

IVABID-7.5 TAB is primarily used to manage symptoms of stable angina pectoris (heart-related chest pain) and chronic heart failure in adults. It is typically prescribed when the heart rate is above 70-75 beats per minute and beta-blockers cannot be tolerated or are not sufficient. It helps to reduce the risk of hospitalization due to worsening heart failure.

How does IVABID-7.5 TAB work?

IVABID-7.5 TAB contains Ivabradine, which works by selectively inhibiting the "funny" (I_f) current in the heart's sinoatrial node, the natural pacemaker. This action slows down the heart rate, allowing more time for the heart to fill with blood and pump it more efficiently. This reduces the heart's workload and oxygen demand without directly affecting blood pressure or myocardial contractility.

What is the usual dosage for IVABID-7.5 TAB?

The dosage of IVABID-7.5 TAB is determined by your doctor based on your condition and heart rate. Typically, treatment may start with a lower dose, such as 5 mg twice daily, and can be adjusted up to a maximum of 7.5 mg twice daily. It should always be taken orally with food, once in the morning and once in the evening.

What are the possible side effects of IVABID-7.5 TAB?

Common side effects can include luminous visual phenomena (temporary brightness or flashes in vision, also called phosphenes), blurred vision, a slow heart rate (bradycardia), headache, dizziness, and increased blood pressure. Some serious but less common side effects may include atrial fibrillation or significant changes to your heartbeat, which require urgent medical attention.

Is IVABID-7.5 TAB safe during pregnancy or breastfeeding?

IVABID-7.5 TAB is generally not recommended for use during pregnancy as it may harm the unborn baby. Women who are pregnant or planning to conceive should consult their doctor, and women of childbearing potential should use reliable contraception while taking this medicine. It is also not recommended for use during breastfeeding, as the drug may cause toxicity to the baby.

Can IVABID-7.5 TAB be taken with other medications?

IVABID-7.5 TAB can interact with several medications. It should be used with caution, or avoided, with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir) and inducers (e.g., rifampicin, phenytoin, St. John's Wort), as these can significantly alter Ivabradine's concentration in the body. Concomitant use with other heart rate-slowing medications like beta-blockers, digoxin, amiodarone, diltiazem, or verapamil may increase the risk of a very slow heart rate. Always inform your doctor about all medications, including herbal supplements, you are taking.

What precautions should be taken while taking IVABID-7.5 TAB?

You should not take IVABID-7.5 TAB if you have severe liver disease, very low blood pressure (below 90/50 mmHg), certain heart rhythm disorders (e.g., sick sinus syndrome, 3rd-degree AV block), or recently worsened heart failure. Caution is advised if you have moderate liver or kidney impairment. This medicine may cause dizziness or blurred vision, so be careful when driving or operating machinery, especially in situations with sudden changes in light or at night. Avoid consuming grapefruit juice as it can increase the concentration of the medicine in your body.

What happens if a dose of IVABID-7.5 TAB is missed?

If you miss a dose of IVABID-7.5 TAB, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should IVABID-7.5 TAB be stored?

IVABID-7.5 TAB should be stored in a cool, dry place, typically below 30°C. Keep it away from direct sunlight and moisture, and ensure it is out of the sight and reach of children.