Teniva M Forte (20 Tablet)

TENIVA M FORTE is an antidiabetic medication manufactured by Intas Pharmaceuticals Ltd, primarily used for managing type 2 diabetes mellitus.

Name

• Brand Name: TENIVA M FORTE (20 TABLET)
• Common Name: Metformin and Teneligliptin combination tablet

Composition

TENIVA M FORTE contains a combination of two active ingredients:

• Metformin: 1000 mg
• Teneligliptin: 20 mg

Metformin is a biguanide that works by decreasing glucose production in the liver and reducing glucose absorption from the intestines, while increasing the body's sensitivity to insulin. Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin secretion from the pancreas and reduces glucagon levels, particularly after meals, thereby lowering blood sugar.

Uses

TENIVA M FORTE is prescribed for the management of type 2 diabetes mellitus in adults. It is used to improve glycemic control, especially when metformin alone is not sufficient, and helps prevent serious complications of diabetes such as kidney damage, blindness, heart attack, and stroke. It is an adjunct to diet and exercise.

Dosage and Administration

The typical dosage guidance is one tablet once daily, or as advised by a physician. It is recommended to take TENIVA M FORTE with food to help reduce stomach upset. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken.

Side Effects

Common Side Effects:

• Nausea, vomiting, diarrhea
• Stomach ache or upset
• Headache
• Low blood sugar levels (hypoglycemia), especially when used with insulin or sulfonylureas
• Weight gain, sweating, respiratory infection

Serious Side Effects:

• Lactic Acidosis: A rare but serious condition (buildup of lactic acid in the blood) characterized by symptoms such as abdominal pain, muscle cramps, severe fatigue, difficulty breathing, dizziness, and cold hands or feet.
• Serious allergic reactions (hives, swelling of face, lips, tongue or throat).
• Severe skin rashes with redness and blistering.
• Vitamin B12 deficiency with long-term use.

Precautions

• Contraindications: Not recommended for patients with severe kidney impairment, liver impairment, type 1 diabetes, diabetic ketoacidosis, severe infection, severe trauma, or congestive heart failure.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy (moderate risk) and breastfeeding (severe risk) due to limited information and potential harm to the infant. Consult a doctor if pregnant, planning pregnancy, or breastfeeding.
• Alcohol Consumption: Excessive alcohol intake should be avoided as it increases the risk of lactic acidosis and can lower blood sugar.
• Pre-existing Conditions: Inform your doctor about any history of kidney, liver, or heart problems, severe infection, or recent surgery.
• Drug Interactions: Inform your doctor about all other medications, herbal preparations, and supplements being taken to prevent potential interactions. Specific interactions can occur with other anti-diabetics, iodine contrast medium, bronchodilators, corticosteroids, and diuretics.
• Monitoring: Regular monitoring of blood sugar levels and kidney function is advisable.

Storage

Store in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of the sight and reach of children. Store below 25°C or between 15-30°C.

Here are the most frequently asked questions about TENIVA M FORTE:

What is TENIVA M FORTE used for?

TENIVA M FORTE Tablet is used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is particularly prescribed for individuals whose blood sugar levels are not adequately controlled by metformin alone, or who require a combination of medications to achieve glycemic control. This medication helps prevent serious complications of diabetes such as kidney damage, blindness, nerve problems, and may reduce the risk of heart attack or stroke.

How does TENIVA M FORTE work?

TENIVA M FORTE is a combination medication containing Metformin (1000 mg) and Teneligliptin (20 mg). Metformin, a biguanide, works by reducing glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels, especially after meals. Together, these actions help to lower both fasting and post-meal blood sugar levels.

What is the usual dosage for TENIVA M FORTE?

TENIVA M FORTE is typically taken orally once daily, or as advised by your physician. It is recommended to take the tablet with or after meals to help reduce stomach upset. The tablet should be swallowed whole and not crushed, chewed, or broken. Your doctor will determine the correct dose and duration based on your condition, blood sugar levels, and other medications you may be taking.

What are the possible side effects of TENIVA M FORTE?

Common side effects of TENIVA M FORTE include diarrhea, nausea, vomiting, headache, stomach ache/upset, and hypoglycemia (low blood sugar). Other possible side effects can include constipation, flatulence, loss of appetite, respiratory infection, weight gain, sweating, palpitations, and altered taste sensations. A serious but rare side effect is lactic acidosis, which requires immediate medical attention and symptoms may include muscle pain, dizziness, tiredness, difficulty breathing, stomach pain, or a slow heart rate. Long-term use of metformin can also lead to Vitamin B12 deficiency.

Is TENIVA M FORTE safe during pregnancy or breastfeeding?

TENIVA M FORTE is generally not recommended for use during pregnancy as its safety has not been established and it may be unsafe. If you are pregnant or planning to conceive, it is best to consult your doctor before taking this medicine. For breastfeeding mothers, TENIVA M FORTE is also generally not recommended as components of the medicine may pass into breast milk and potentially harm the infant.

Can it be taken with other medications?

TENIVA M FORTE can interact with certain medications. It's crucial to inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements. Medications that can interact include certain anti-diabetics (like sulfonylureas, glimepiride, pioglitazone), iodine contrast medium, bronchodilators (e.g., salbutamol), corticosteroids (e.g., hydrocortisone), diuretics (e.g., furosemide), cationic medicines (e.g., cimetidine, amiloride, ranitidine), and certain antibiotics (e.g., rifampicin, tetracycline). Alcohol consumption should be avoided as it increases the risk of lactic acidosis.

What precautions should be taken?

Do not take TENIVA M FORTE if you are allergic to teneligliptin, metformin, or any other ingredients. Inform your doctor if you have liver, kidney, or heart problems, severe infection, severe trauma, adrenal or pituitary insufficiency, or are severely dehydrated. It is contraindicated in patients with severe renal impairment, severe heart problems (like acute heart failure), and uncontrolled diabetes. Excessive alcohol intake should be avoided due to an increased risk of lactic acidosis. Regular monitoring of blood sugar levels and kidney function is advisable during therapy.

What happens if a dose is missed?

If you miss a dose of TENIVA M FORTE, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Always consult your doctor before making any changes to your dosage regimen.

How should it be stored?

Store TENIVA M FORTE at room temperature, between 15 to 30°C, in a dry, dark place, away from direct light and moisture. Keep the medicine out of the sight and reach of children. Ensure to use the medicine before its expiry date.