Dapanorm Duo 10 Mg Tablet (10 Tab)

DAPANORM DUO 10 MG TABLET

Name: Dapanorm DUO-10 Tablet is the brand name for this medicine, manufactured by Alkem Laboratories Ltd.

Composition: Each tablet contains a combination of two active ingredients: Dapagliflozin 10 mg and Sitagliptin 100 mg.

Uses: Dapanorm DUO-10 Tablet is prescribed for the treatment of Type 2 Diabetes Mellitus in adults. It is used to improve blood sugar control, especially when diet, exercise, and other medications alone are insufficient. This medicine also helps reduce the risk of long-term diabetes complications such as kidney damage, nerve damage, vision issues, and cardiovascular disease. Some indications also include its use in adults with chronic kidney disease to protect kidney function.

Dosage and Administration: This medication should be taken orally, usually once daily in the morning, with or without food, as directed by a healthcare professional. It is important to take it at the same time each day to maintain consistent blood sugar levels. Patients should not exceed the recommended dose or stop taking the medicine abruptly without consulting their doctor, as this may lead to increased blood sugar levels and associated complications.

Side Effects:

• Common: Urinary tract infections (UTIs), genital yeast infections, headache, nausea, vomiting, diarrhea, frequent urination, dizziness, light-headedness, stuffy or runny nose, sore throat, flatulence, constipation, stomach pain, upper respiratory tract infection, swelling of hands or legs, and dry mouth.
• Serious: Seek immediate medical attention if you experience severe and persistent stomach pain (which may radiate to the back, with or without nausea and vomiting), symptoms of acute pancreatitis, or a serious allergic reaction such as rash, hives, blisters, swelling of the face, tongue, lips, or throat causing difficulty in breathing or swallowing.

Precautions: Dapanorm DUO-10 Tablet is contraindicated in patients with Type 1 Diabetes Mellitus, severe kidney impairment (including end-stage renal disease or those on dialysis), severe liver disease, or a known allergy to dapagliflozin, sitagliptin, or any other ingredients. Caution is advised for pregnant or breastfeeding women, and consultation with a doctor is essential. It may interact with other medicines such as sulfonylureas, insulin (increasing the risk of low blood sugar), diuretics, and NSAIDs (increasing the risk of kidney problems). Regular blood sugar monitoring is crucial during treatment. Avoid alcohol consumption as it may affect blood sugar control and increase the risk of certain side effects.

Storage: Store Dapanorm DUO-10 Tablet in a cool and dry place, away from direct sunlight, ideally below 30°C. Keep it out of the sight and reach of children.

DAPANORM DUO 10 MG TABLET is a combination medicine containing Dapagliflozin (10 mg) and Sitagliptin (100 mg), manufactured by Alkem Laboratories Ltd.. It is primarily used for the management of type 2 diabetes mellitus in adults.

What is DAPANORM DUO 10 MG TABLET used for?

DAPANORM DUO 10 MG TABLET is used to treat type 2 diabetes mellitus in adults. It helps to control high blood sugar levels, especially when diet, exercise, and other medications alone are not sufficient. By managing blood sugar, it helps prevent serious complications of diabetes such as kidney damage, nerve damage, eyesight loss, diabetic foot ulcer, and delayed wound healing. It may also help reduce the risk of heart attack, heart failure, or other cardiovascular events, and can be used to treat chronic kidney disease in adults with reduced kidney function.

How does DAPANORM DUO 10 MG TABLET work?

DAPANORM DUO 10 MG TABLET combines two active ingredients: Dapagliflozin and Sitagliptin.

• Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by blocking the reabsorption of glucose in the kidneys, leading to increased excretion of glucose through the urine, thereby lowering blood sugar levels.
• Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of natural substances called incretins in the body, which, in turn, increase insulin levels after a meal and decrease the amount of glucose the liver produces. This helps to control blood sugar levels.

What is the usual dosage of DAPANORM DUO 10 MG TABLET?

DAPANORM DUO 10 MG TABLET should be taken orally as directed by your doctor, usually once daily, with or without food, preferably at the same time each day. The dosage is determined by your medical condition and response to treatment. It is important not to exceed the prescribed dose or stop taking the medication without consulting your doctor.

What are the possible side effects of DAPANORM DUO 10 MG TABLET?

Common side effects of DAPANORM DUO 10 MG TABLET include urinary tract infections, genital yeast infections, headache, nausea, diarrhea, stuffy or runny nose, and sore throat. Some individuals may also experience increased urination, dizziness, or light-headedness.

Serious side effects, though less common, can include severe allergic reactions (rash, hives, swelling of the face, tongue, lips, or throat), inflammation of the pancreas (pancreatitis) with severe abdominal pain, or diabetic ketoacidosis. If you experience any severe or persistent side effects, contact your doctor immediately.

Is DAPANORM DUO 10 MG TABLET safe during pregnancy or breastfeeding?

Limited information is available on the effect of DAPANORM DUO 10 MG TABLET during pregnancy. It should only be used in pregnant women if clearly necessary, and after a doctor has weighed the benefits and risks.

DAPANORM DUO 10 MG TABLET is generally not recommended during breastfeeding as it is not known if it passes into human breast milk. It is advisable to consult your doctor to understand the potential risks and benefits if you are a nursing mother.

Can DAPANORM DUO 10 MG TABLET be taken with other medications?

It is crucial to inform your doctor about all other medicines, herbal products, or supplements you are currently taking or plan to take to avoid potential drug interactions.

DAPANORM DUO 10 MG TABLET may interact with:

• Other anti-diabetic medications (e.g., insulin, sulfonylureas), which may increase the risk of very low blood sugar levels (hypoglycemia).
• Diuretics (water pills like furosemide, hydrochlorothiazide), which may increase the risk of dehydration and low blood pressure.
• Certain antifungals (e.g., ketoconazole, itraconazole), antivirals (e.g., ritonavir), antibiotics (e.g., clarithromycin), immunosuppressants (e.g., ciclosporin), and cardiac glycosides (e.g., digoxin).
• NSAIDs (e.g., ibuprofen, naproxen) can increase the risk of kidney problems.

What precautions should be taken?

• Do not stop taking DAPANORM DUO 10 MG TABLET without consulting your doctor, even if your blood sugar levels are stable, as abrupt discontinuation can lead to a rebound increase in blood sugar levels.
• Maintain a healthy diet and engage in regular physical activity as recommended by your doctor to enhance the effectiveness of the medication.
• Drink plenty of fluids to prevent dehydration, as this medicine can cause increased urination.
• Limit alcohol consumption, as it may affect blood sugar control and increase the likelihood of side effects.
• Inform your doctor if you have kidney or liver problems, heart disease, a history of pancreatitis, or urinary tract infections.
• Monitor your blood sugar levels regularly.
• DAPANORM DUO 10 MG TABLET may cause dizziness or low blood sugar, so drive or operate machinery only if you feel alert and stable.

What happens if a dose is missed?

If you miss a dose of DAPANORM DUO 10 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed dose.

How should it be stored?

Store DAPANORM DUO 10 MG TABLET in a cool and dry place, away from direct sunlight, and out of the sight and reach of children. It should generally be stored below 30°C.