Glz Mex Tablet (10 Tab)

GLZ MEX TABLET (10 TAB) by ALEMBIC PHARMACEUTICALS LIMITED

Name

Brand Name: GLZ MEX TABLET Common Name: Gliclazide and Metformin Tablet

Composition

GLZ MEX TABLET contains a combination of two active ingredients:

• Gliclazide: Typically 60 mg (Modified Release)
• Metformin: Typically 500 mg (Extended Release)

(Note: Some formulations may contain Gliclazide 30mg instead of 60mg, such as GLZ MEX 30mg/500mg Tablet.)

Uses

GLZ MEX TABLET is primarily used for the management of Type 2 Diabetes Mellitus in adults. It helps to control high blood sugar levels when diet and exercise alone are insufficient. This medicine works by stimulating the pancreas to release more insulin (Gliclazide) and by reducing glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's response to insulin (Metformin). By regulating blood sugar, it helps prevent serious complications of diabetes such as kidney damage, blindness, nerve problems, and cardiovascular issues.

Dosage and Administration

This medicine should be taken in the dose and duration as advised by your doctor.

• Swallow the tablet whole with a glass of water.
• Do not crush, chew, or break the tablet.
• It is generally recommended to take GLZ MEX TABLET with food to avoid stomach upset.
• For best results, take it regularly at the same time each day.
• Do not adjust your dose or stop taking the medicine without consulting your doctor.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain or gastric pain
• Loss of appetite
• Taste disturbance (metallic taste)
• Headache
• Constipation
• Hypoglycemia (low blood sugar), characterized by sweating, dizziness, headache, shaking, palpitations, and hunger pangs.

Most side effects are temporary and resolve upon discontinuing the medicine. However, if any side effects persist or worsen, consult your doctor.

Precautions

• Hypoglycemia: Be aware of the signs of low blood sugar and carry a fast-acting source of glucose (like sugary food or fruit juice).
• Alcohol: Avoid alcohol consumption as it can increase the risk of low blood sugar (hypoglycemia) and lactic acidosis.
• Pregnancy: Not recommended for use in pregnant women; consult your doctor.
• Breastfeeding: Consult your doctor before taking this medicine if you are breastfeeding.
• Kidney Impairment: Use with caution in mild-to-moderate kidney impairment. It is contraindicated in severe kidney impairment. Regular monitoring of kidney function is advisable.
• Liver Impairment: Use with caution in patients with liver problems. It is contraindicated in severe liver disease.
• Heart Failure: Patients with heart conditions should be cautious, as this medication may exacerbate symptoms. It is contraindicated in heart disease.
• Allergy: Do not take if you are allergic to Gliclazide, Metformin, or any other components of the tablet.
• Diabetic Ketoacidosis: Contraindicated in diabetic ketoacidosis.
• Children: Not recommended for use in children as safety and effectiveness have not been established.
• Driving/Operating Machinery: May cause dizziness or confusion due to low blood sugar; use caution.
• Vitamin B12 Deficiency: Long-term use can lead to vitamin B12 deficiency.
• Thyroid: May lower thyroid-stimulating hormone (TSH), so an annual check-up of TSH is suggested.

Storage

Store in a cool and dry place, away from direct sunlight. Keep out of sight and reach of children. Store below 30°C.

What is GLZ MEX TABLET used for?

GLZ MEX TABLET is primarily used to treat type 2 diabetes mellitus in adults. It helps control high blood sugar levels when diet and exercise alone are not sufficient. This medication also helps prevent serious complications of diabetes, such as kidney damage, blindness, nerve problems, heart attack, and stroke.

How does GLZ MEX TABLET work?

GLZ MEX TABLET contains two active ingredients: Gliclazide and Metformin. Gliclazide, a sulfonylurea, stimulates the pancreas to release more insulin. Metformin, a biguanide, works by reducing the production of glucose by the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Together, these actions help to lower and manage blood sugar levels.

What is the usual dosage for GLZ MEX TABLET?

The dosage of GLZ MEX TABLET is determined by your doctor based on your blood sugar levels and response to treatment. It is typically taken orally with food, usually once or twice daily, at the same time each day for optimal results. It is crucial to swallow the tablet whole and not to chew, crush, or break it. Do not adjust your dose without consulting your doctor.

What are the possible side effects of GLZ MEX TABLET?

Common side effects may include hypoglycemia (low blood sugar), nausea, vomiting, diarrhea, abdominal pain, constipation, headache, and altered taste. Hypoglycemia can manifest as dizziness, sweating, headache, and shaking. More serious but rare side effects like lactic acidosis can occur. Long-term use may also lead to vitamin B12 deficiency. Consult your doctor if any side effects persist or worsen.

Is GLZ MEX TABLET safe during pregnancy or breastfeeding?

GLZ MEX TABLET is generally not recommended during pregnancy as it may be unsafe and could harm the unborn baby. It is also not recommended during breastfeeding, as it may pass into breast milk and potentially affect the newborn. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medicine.

Can GLZ MEX TABLET be taken with other medications?

GLZ MEX TABLET can interact with other medications, potentially altering their effects or increasing the risk of side effects like hypoglycemia. Inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid possible interactions. For instance, other anti-diabetic agents, certain ACE inhibitors, and NSAIDs may intensify the hypoglycemic effect. Alcohol consumption should be avoided.

What precautions should be taken while taking GLZ MEX TABLET?

It is important to take GLZ MEX TABLET with food to avoid stomach upset. Regularly monitor your blood sugar levels as advised by your doctor. Be aware of the signs of low blood sugar (hypoglycemia) and carry a fast-acting source of glucose (like sugary food or fruit juice) with you. Avoid alcohol consumption as it can increase the risk of low blood sugar and lactic acidosis. Inform your doctor if you have kidney disease, liver disease, heart conditions, or vitamin B12 deficiency, as these conditions may require dose adjustments or contraindicate its use.

What happens if a dose of GLZ MEX TABLET is missed?

If you miss a dose of GLZ MEX TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one, as this can cause a dangerous drop in blood glucose levels.

How should GLZ MEX TABLET be stored?

GLZ MEX TABLET should be stored in a cool and dry place, away from direct sunlight, ideally at room temperature (between 15°C and 30°C or below 30°C). Keep it out of sight and reach of children.