Neptaz 50 Mg Tablet (14 Tab)

NEPTAZ 50 MG TABLET

Name: Neptaz 50 mg Tablet Brand Name: Neptaz Common Name: Sacubitril and Valsartan

Composition: NEPTAZ 50 MG TABLET contains a combination of two active ingredients: Sacubitril (24 mg) and Valsartan (26 mg). It is a cardiovascular agent classified as an angiotensin receptor-neprilysin inhibitor (ARNi). Sacubitril works by inhibiting neprilysin, an enzyme that breaks down certain peptides, leading to vasodilation and reduced sodium retention. Valsartan is an angiotensin receptor blocker (ARB) that blocks the effects of angiotensin II, a hormone that causes blood vessels to constrict, thereby relaxing and widening blood vessels.

Uses: NEPTAZ 50 MG TABLET is primarily used for the treatment of long-term (chronic) heart failure in adults and in children above one year of age. It helps to reduce the risk of death and hospitalization in patients where the heart is weak and cannot pump enough blood to the body. This medication improves heart function, alleviates symptoms such as breathlessness and fatigue, and enhances overall well-being.

Dosage and Administration: This medicine should be taken exactly as instructed by your doctor. The tablets should be swallowed whole with a glass of water and should not be crushed, chewed, or broken. NEPTAZ 50 MG TABLET can be taken with or without food, but it is recommended to take it at the same time each day for maximum benefits and consistency. Do not stop taking the medicine suddenly, as it may worsen your condition.

Side Effects: Common side effects may include:

• Low blood pressure (hypotension)
• Dizziness, light-headedness, or fainting
• Increased potassium levels in the blood (hyperkalemia)
• Cough
• Impaired renal function
• Nausea, stomach pain, or diarrhea
• Tiredness or weakness

Serious side effects, though rare, requiring immediate medical attention include:

• Severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat, which may cause difficulties in breathing or swallowing)
• Hallucinations or changes in sleep patterns

Precautions:

• Allergies: Do not take NEPTAZ 50 MG TABLET if you are allergic to sacubitril, valsartan, or any of its ingredients, or if you have a history of angioedema with ACE inhibitors or ARBs.
• Drug Interactions: Inform your doctor about all medications you are taking, especially ACE inhibitors (should not be taken within 36 hours before or after NEPTAZ), aliskiren, lithium, and potassium supplements.
• Medical Conditions: Use with caution in patients with kidney or liver problems, low blood pressure, dehydration, or diabetes. Regular monitoring of blood pressure and potassium levels is advised.
• Pregnancy and Breastfeeding: NEPTAZ 50 MG TABLET is contraindicated during pregnancy and breastfeeding due to potential harm to the baby.
• Driving: Avoid driving or operating heavy machinery if you experience dizziness or tiredness.
• Alcohol: Limit alcohol consumption as it may worsen dizziness and hypotension.

Storage: Store NEPTAZ 50 MG TABLET at room temperature (below 30°C or between 10ºC to 25ºC), away from direct light and moisture. Keep it in the original package and out of the sight and reach of children and pets.

What is NEPTAZ 50 MG Tablet used for?

NEPTAZ 50 MG Tablet is primarily used to treat chronic heart failure in adults, particularly in patients with a reduced ejection fraction. It helps to reduce the risk of cardiovascular death and hospitalization associated with this condition. It is also used in children above one year of age for heart failure.

How does NEPTAZ 50 MG Tablet work?

NEPTAZ 50 MG Tablet is a combination medicine containing sacubitril and valsartan, classified as an angiotensin receptor-neprilysin inhibitor (ARNI). Sacubitril works by inhibiting an enzyme called neprilysin, which leads to the relaxation and widening of blood vessels, increased excretion of sodium through urine, and increased urination. Valsartan blocks the effects of angiotensin II, a hormone that constricts blood vessels. Together, these actions help to lower blood pressure, reduce the strain on the heart, and make it easier for the heart to pump blood throughout the body.

What is the usual dosage for NEPTAZ 50 MG Tablet?

The dosage and duration of treatment for NEPTAZ 50 MG Tablet are determined by your doctor based on your medical condition and response to the medication. It can be taken with or without food, but it is recommended to take it at the same time each day for consistent absorption. The tablets should be swallowed whole with a glass of water and not chewed, crushed, or broken.

What are the possible side effects of NEPTAZ 50 MG Tablet?

Common side effects of NEPTAZ 50 MG Tablet include low blood pressure (hypotension), increased potassium levels in the blood (hyperkalemia), dizziness, cough, and impaired kidney function. Other possible side effects may include headache, nausea, diarrhea, tiredness, and weakness. A more serious, though rare, side effect is angioedema (swelling of the face, lips, tongue, or throat), which requires immediate medical attention.

Is NEPTAZ 50 MG Tablet safe during pregnancy or breastfeeding?

NEPTAZ 50 MG Tablet is not recommended for use during pregnancy, especially after the first three months, as it can cause serious harm to the developing baby. It is also not recommended for use by breastfeeding women. If you are pregnant or breastfeeding, or planning to become pregnant, consult your doctor for alternative treatment options.

Can NEPTAZ 50 MG Tablet be taken with other medications?

It is crucial to inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential drug interactions. NEPTAZ 50 MG Tablet should not be taken with ACE inhibitors (a type of blood pressure medicine) and there should be a 36-hour gap before or after taking an ACE inhibitor. It is also contraindicated if you are taking Aliskiren (another blood pressure-lowering medication), especially if you have diabetes or impaired kidney function. Caution is advised when taking it with potassium supplements, certain blood pressure medications (like amlodipine, lisinopril), and other heart medications (such as digoxin).

What precautions should be taken while using NEPTAZ 50 MG Tablet?

Before starting NEPTAZ 50 MG Tablet, inform your doctor if you have kidney or liver problems, a history of angioedema, low blood pressure, or diabetes. Regular monitoring of blood pressure and potassium levels is often advised during treatment. If you experience dizziness or lightheadedness, particularly when changing position, rise slowly. Avoid consuming high-potassium foods or supplements without consulting your doctor.

What happens if a dose of NEPTAZ 50 MG Tablet is missed?

If you miss a dose of NEPTAZ 50 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of adverse effects.

How should NEPTAZ 50 MG Tablet be stored?

NEPTAZ 50 MG Tablet should be stored at room temperature (typically between 10°C to 25°C or below 30°C). Keep it in its original packaging to protect it from light and moisture. Always store this medicine out of the sight and reach of children and pets.