Glucoryl Mp 2 Mg Tablet (15 Tab)

GLUCORYL MP 2 MG TABLET (15 TAB)

Glucoryl MP 2 MG Tablet is a combination medication manufactured by Alkem Laboratories Ltd., primarily used in the management of Type 2 Diabetes Mellitus.

• Name: Glucoryl-MP2 Tablet SR, Glucoryl MP 2 MG Tablet.

• Composition: Each tablet contains a combination of three active ingredients:

  • Glimepiride (2 mg)
  • Metformin (500 mg)
  • Pioglitazone (15 mg)

• Uses: Glucoryl MP 2 MG Tablet is prescribed for adults with Type 2 Diabetes Mellitus to control high blood sugar levels when diet, exercise, and single or dual anti-diabetic therapies are insufficient. It works by enhancing insulin utilization, decreasing glucose production in the liver, and increasing the body's sensitivity to insulin. This helps prevent serious complications of diabetes such as kidney damage, nerve problems, blindness, and cardiovascular disease.

• Dosage and Administration: This medication should be taken in the dose and duration advised by your doctor, preferably with or immediately after meals to minimize stomach upset and reduce the risk of hypoglycemia. Swallow the tablet whole with a glass of water; do not crush or chew it. Do not double a dose to compensate for a missed one.

• Side Effects: Common side effects may include:

  • Hypoglycemia (low blood sugar levels)
  • Nausea, diarrhea, stomach pain, vomiting
  • Headache, dizziness
  • Anemia, weakness
  • Bone fractures, respiratory tract infections
  • Metallic taste, changes in taste
  • Joint pain, back pain, muscle pain
  • Weight gain

  Serious side effects, though rare, can include lactic acidosis (signs include cold hands/feet, dizziness, unusual muscle pain, trouble breathing) and symptoms of heart failure (unusual shortness of breath, rapid weight gain, swelling).

• Precautions:

  • Inform your doctor about any pre-existing kidney, liver, or heart conditions.
  • Not recommended for patients with Type 1 Diabetes Mellitus, bladder cancer, severe heart failure, or lactic acidosis.
  • Avoid alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis.
  • Pregnant or breastfeeding individuals should consult a doctor before use, as it may be unsafe during pregnancy and can pass into breast milk.
  • Inform your doctor about any other medications you are taking, including antidiabetics, NSAIDs, antibiotics, antifungals, anticoagulants, hormone replacement therapy, and antidepressants, as interactions may occur.
  • Regular monitoring of blood sugar levels and kidney function tests is recommended during treatment.

• Storage: Store in a cool and dry place, away from direct sunlight, at temperatures between 10ºC to 25ºC or below 30ºC. Keep out of reach and sight of children.

What is GLUCORYL MP 2 MG Tablet used for?

GLUCORYL MP 2 MG Tablet is an antidiabetic medicine primarily used to manage Type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and treatment with a single antidiabetic agent are not sufficient to adequately control blood sugar levels. This medication helps to lower both fasting and post-meal blood glucose levels and is essential in preventing or delaying serious complications of diabetes, such as kidney damage, nerve problems, blindness, and limb amputations.

How does GLUCORYL MP 2 MG Tablet work?

GLUCORYL MP 2 MG Tablet is a combination of three active ingredients: Glimepiride, Metformin, and Pioglitazone, which work together through different mechanisms to control blood sugar.

• Glimepiride: Stimulates the pancreas to produce and release more insulin, a hormone that helps glucose move from the blood into cells for energy.
• Metformin: Works by reducing the production of glucose in the liver, increasing the body's sensitivity to insulin, and slowing down the absorption of glucose from the intestines.
• Pioglitazone: Improves the body's response to insulin (insulin sensitizer) in the liver, muscles, and fat cells, helping them to remove glucose from the blood more effectively.

What is the usual dosage for GLUCORYL MP 2 MG Tablet?

The dosage of GLUCORYL MP 2 MG Tablet is determined by your doctor based on your medical condition, blood sugar levels, and response to treatment. It is typically taken orally, once or twice daily, preferably with meals to minimize stomach upset. The tablet should be swallowed whole with a glass of water and not be crushed or chewed. It is crucial to follow your doctor's instructions carefully and not adjust the dosage without consulting them.

What are the possible side effects of GLUCORYL MP 2 MG Tablet?

Common side effects can include hypoglycemia (low blood sugar levels), nausea, diarrhea, stomach pain, headache, dizziness, loss of appetite, metallic taste, joint pain, back pain, muscle pain, upper respiratory tract infections, and weight gain. More serious, though rare, side effects that require immediate medical attention include signs of lactic acidosis (such as cold hands or feet, dizziness, irregular heartbeat, unusual muscle pain, trouble breathing, severe tiredness, stomach pains, nausea, or vomiting) and symptoms of heart failure (like unusual shortness of breath, rapid increase in weight, or swelling, especially in the ankles or legs).

Is GLUCORYL MP 2 MG Tablet safe during pregnancy or breastfeeding?

Pregnancy: GLUCORYL MP 2 MG Tablet is generally not recommended for use during pregnancy as there are limited human data on its safety, and animal studies have shown harmful effects on the developing baby. You should consult your doctor if you are pregnant or planning a pregnancy. Breastfeeding: It is probably unsafe to use GLUCORYL MP 2 MG Tablet while breastfeeding, as it is not known if the medicine passes into human milk and could potentially harm the baby. Consult your doctor before using this medication if you are a nursing mother.

Can GLUCORYL MP 2 MG Tablet be taken with other medications?

GLUCORYL MP 2 MG Tablet can interact with various other medications. It is essential to inform your doctor about all prescription and non-prescription medicines, vitamins, and herbal supplements you are currently taking to avoid potential interactions. Interactions may occur with other antidiabetics (which can increase the risk of low blood sugar), non-steroidal anti-inflammatory agents (NSAIDs), antibiotics, antifungals, anticoagulants (blood thinners), hormone replacement therapy, certain blood pressure medications, corticosteroids, and thyroid products. Cationic medicines like amiloride, digoxin, ranitidine, and vancomycin may also increase the risk of metformin toxicity.

What precautions should be taken while using GLUCORYL MP 2 MG Tablet?

Before taking GLUCORYL MP 2 MG Tablet, inform your doctor if you have any liver, kidney, or heart problems. This medicine is not recommended for patients with severe heart failure, severe kidney or liver failure, bladder cancer, or lactic acidosis, and is contraindicated in Type 1 diabetes mellitus. Avoid consuming alcohol, as it can significantly increase the risk of hypoglycemia and a serious condition called lactic acidosis. Regular monitoring of blood sugar levels is crucial during treatment. Always carry a fast-acting source of sugar, like glucose tablets or fruit juice, to treat symptoms of low blood sugar. Exercise caution if you need to drive or operate machinery, as fluctuations in blood sugar can affect your ability. The medication is not recommended for children or adolescents. Special caution is advised for elderly patients.

What happens if a dose of GLUCORYL MP 2 MG Tablet is missed?

If you miss a dose of GLUCORYL MP 2 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can lead to dangerously low blood sugar levels (hypoglycemia). Missing a dose can result in high blood sugar.

How should GLUCORYL MP 2 MG Tablet be stored?

GLUCORYL MP 2 MG Tablet should be stored in a cool, dry place, away from direct sunlight. It is generally recommended to store it below 30°C. Always keep the medicine out of the reach and sight of children.