Nitrohart Tablet (10 Tab)

NITROHART TABLET by MANKIND PHARMA LTD.

Name:

• Brand Name: Nitrohart Tablet
• Common Name: Hydralazine and Isosorbide Dinitrate Tablets

Composition: Each tablet contains a combination of two active ingredients:

• Hydralazine (37.5 mg)
• Isosorbide Dinitrate (20 mg)

Uses: Nitrohart Tablet is primarily used in the management of heart failure, especially in patients who have not responded adequately to other medications. It helps improve cardiac performance by reducing the heart's workload and enhancing blood flow. It may also be used for the treatment and prevention of angina pectoris, a type of chest pain, by widening blood vessels and improving blood flow to the heart.

Dosage and Administration: This medicine is typically taken orally, as directed by a doctor. It can be taken with or without food, usually three times daily, or as prescribed. The exact dosage and duration depend on the patient's medical condition and response to treatment; it should not be modified without a doctor's advice. Do not stop taking the medication abruptly, even if feeling better, to avoid serious complications.

Side Effects: Common side effects include headache, dizziness, nausea, vomiting, and lightheadedness. More serious, though rare, side effects can include hypotension (low blood pressure) and tachycardia (faster than normal heart rate). Headaches may be more frequent at the start of treatment but often lessen over time.

Precautions:

• Hypotension: Use with caution in patients with low blood pressure as it may further decrease blood pressure.
• Pregnancy & Breastfeeding: Consult a doctor. It may be unsafe during pregnancy (limited human studies show potential adverse effects) but is likely safe during breastfeeding.
• Alcohol: Avoid alcohol consumption as it can increase the blood pressure-lowering effect and may cause a disulfiram-like reaction (flushing, increased heart rate, nausea, chest pain, low blood pressure).
• Driving: May cause dizziness, affecting the ability to drive or operate machinery.
• Kidney/Liver Disease: Use with caution in patients with severe kidney disease; dose adjustments may be necessary. It is generally considered safe for liver patients, but consultation with a doctor is advised.
• Allergies: Contraindicated in individuals with known hypersensitivity to hydralazine, isosorbide dinitrate, or any tablet component.

Storage: Store the medicine in its original container, tightly closed, in a cool and dry place, away from moisture and heat. Keep out of sight and reach of children. Dispose of unused medicine safely.

Here are frequently asked questions about NITROHART TABLET by MANKIND PHARMA LTD.:

What is Nitrohart Tablet used for?

Nitrohart Tablet is primarily used to manage heart failure, especially in patients who have not responded adequately to other medications. It helps to improve symptoms, enhance the quality of life, and reduce the workload on the heart. It can also be used for the treatment and prevention of angina pectoris (chest pain) caused by coronary artery disease.

How does Nitrohart Tablet work?

Nitrohart Tablet is a combination medicine containing Isosorbide Dinitrate and Hydralazine. Isosorbide Dinitrate is a nitrate that works by relaxing the blood vessels and decreasing the heart's oxygen demand. Hydralazine is a direct-acting vasodilator that relaxes and widens arteries and arterioles, reducing peripheral resistance and lowering blood pressure. Together, they make it easier for the heart to pump blood effectively, improving overall cardiac performance.

What is the usual dosage for Nitrohart Tablet?

The exact dosage and frequency are determined by your doctor based on your medical condition and how you respond to the medicine. It is typically taken with food, regularly at a fixed time each day, often three times daily. You should swallow the tablet whole with water and avoid crushing or chewing it. Do not modify your dose without your doctor's advice.

What are the possible side effects of Nitrohart Tablet?

Common side effects include headache, dizziness, nausea, vomiting, and lightheadedness. Less common but severe side effects can include hypotension (very low blood pressure) and tachycardia (faster than normal heart rate). Most common side effects are temporary and usually resolve over time. However, if any side effects persist or worsen, you should consult your doctor.

Is Nitrohart Tablet safe during pregnancy or breastfeeding?

Caution is advised during pregnancy as animal studies have shown possible harm to the developing baby, and limited human studies suggest it may be unsafe. It is best to consult your doctor, who will weigh the benefits and risks. Regarding breastfeeding, limited human data suggests that the drug does not represent a significant risk to the baby, and it is generally considered probably safe if prescribed by an expert. Hydralazine, one of the components, passes into breast milk, so consultation with your doctor is recommended.

Can Nitrohart Tablet be taken with other medications?

Nitrohart Tablet can interact with several medications. It may interact with other antihypertensives (like amlodipine or lisinopril), potentially leading to very low blood pressure. Concomitant use with PDE-5 inhibitors (such as sildenafil and tadalafil, used for erectile dysfunction) can cause severe hypotension and should be avoided. NSAIDs (like ibuprofen) can reduce the efficacy of hydralazine. Hydralazine may also increase levels of antiarrhythmics like procainamide. Always inform your doctor about all other medications you are taking to avoid potential interactions.

What precautions should be taken while using Nitrohart Tablet?

Avoid taking Nitrohart Tablet if you have low blood pressure, as it can further decrease it. Alcohol consumption should be avoided or limited as it can increase the blood pressure-lowering effect and worsen dizziness. Since the medicine can cause dizziness or lightheadedness, avoid driving or operating machinery until you know how it affects you; it is advised to rise slowly from a sitting or lying position. Individuals with severe kidney disease should use it with caution, and dose adjustment may be necessary. Inform your doctor if you have liver problems, although it is generally considered safe for liver patients if prescribed.

What happens if a dose of Nitrohart Tablet is missed?

If you forget to take your Nitrohart Tablet at the usual time, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and return to your regular dosing schedule. Do not double up on doses without consulting your doctor.

How should Nitrohart Tablet be stored?

Keep this medicine in the container or pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label, typically below 30°C in a cool and dry place, away from direct sunlight. Ensure it is kept out of sight and reach of children and pets. Dispose of any unused medicine safely.