Ondero Met 2.5 Mg /1000 Mg Tablet (10 Tab)

ONDERO MET 2.5 MG /1000 MG TABLET

Name:

• Brand Name: Ondero Met 2.5 MG /1000 MG TABLET
• Manufacturer: LUPIN LTD.

Composition: Ondero Met 2.5 MG /1000 MG Tablet contains two active ingredients:

• Linagliptin (2.5 mg) (a DPP-4 inhibitor)
• Metformin (1000 mg) (a biguanide)

Uses: This medicine is primarily prescribed for adults with Type 2 diabetes mellitus to help control high blood sugar levels. It works by improving insulin action, reducing glucose production in the liver, and increasing insulin release from the pancreas. It helps lower both fasting and post-meal blood glucose levels. Managing blood glucose is crucial to prevent serious complications like kidney damage, eye damage, nerve problems, and cardiovascular issues.

Dosage and Administration: Ondero Met 2.5 MG /1000 MG Tablet should be taken orally with meals to minimize gastrointestinal upset. The typical dosage is usually once or twice daily, as directed by a doctor. The tablet should be swallowed whole and not crushed or chewed. Do not alter the dosage or discontinue the medicine without consulting your doctor.

Side Effects:

• Common: Nausea, headache, dizziness, fatigue, vomiting, skin rash, diarrhea, indigestion, stomach pain, and altered taste.
• Serious/Rare: Hypoglycemia (low blood sugar), particularly when taken with other antidiabetic medications, lactic acidosis (a rare but serious condition, especially with kidney or heart problems, in elderly patients, or with excessive alcohol intake), and long-term use may lead to Vitamin B12 deficiency. Pancreatitis is also a possible risk.

Precautions: Inform your doctor about any history of kidney, liver, or heart disease, or pancreatic issues. Ondero Met is contraindicated in severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, diabetic ketoacidosis, and Type 1 diabetes. Excessive alcohol consumption should be avoided as it can increase the risk of lactic acidosis and hypoglycemia. Pregnant or breastfeeding women should consult their doctor before use. Regular monitoring of blood sugar levels and kidney function is essential during treatment. Carry a sugar source to manage unexpected low blood sugar.

Storage: Store in a cool and dry place, below 30°C. Keep it in its original container, tightly closed, protected from moisture and heat, and out of reach of children and pets.

Ondero Met 2.5 mg/1000 mg Tablet: Frequently Asked Questions

Ondero Met 2.5 mg/1000 mg Tablet is a combination medication containing Linagliptin (2.5 mg) and Metformin (1000 mg). It is primarily used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus.

What is Ondero Met 2.5 mg/1000 mg Tablet used for?

Ondero Met 2.5 mg/1000 mg Tablet is prescribed to help control high blood sugar levels in adults with Type 2 diabetes. It is often used when diet, exercise, and metformin alone are not sufficient to achieve adequate glycemic control. This medication helps in improving overall glycemic control by enhancing insulin sensitivity and decreasing hepatic glucose production.

How does Ondero Met 2.5 mg/1000 mg Tablet work?

This medicine combines two active ingredients: Linagliptin and Metformin.

• Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of natural hormones called incretins, which are released after meals. These incretins stimulate the pancreas to produce more insulin in a glucose-dependent manner and reduce the amount of sugar produced by the liver.
• Metformin belongs to a class of medications called biguanides. It primarily works by reducing glucose production in the liver, delaying the absorption of glucose from the intestines, and improving the body's sensitivity to insulin, thereby enhancing glucose uptake and utilization by muscles.

Together, these mechanisms lead to better control of blood sugar levels.

What is the usual dosage for Ondero Met 2.5 mg/1000 mg Tablet?

The exact dosage of Ondero Met 2.5 mg/1000 mg Tablet is determined by your doctor based on your individual response to the medicine and the severity of your condition. Typically, it is taken with meals to minimize the risk of stomach upset. It is important to swallow the tablet whole and not to crush, chew, or split it.

What are the possible side effects of Ondero Met 2.5 mg/1000 mg Tablet?

Common side effects can include:

• Low blood sugar (hypoglycemia), especially when taken with other anti-diabetic medications, alcohol, or by delaying/skipping a meal. Symptoms may include dizziness, sweating, hunger pangs, and dry mouth.
• Upper respiratory tract infection, including symptoms like a runny nose, sneezing, and sore throat (nasopharyngitis).
• Diarrhea, nausea, vomiting, and stomach pain.
• Changes in taste, sometimes described as a metallic taste.

A rare but serious side effect associated with metformin is lactic acidosis, which can cause symptoms like unusual tiredness, rapid breathing, muscle pain, stomach discomfort, and dizziness. If you experience any severe or worsening symptoms, consult your doctor immediately.

Is Ondero Met 2.5 mg/1000 mg Tablet safe during pregnancy or breastfeeding?

Ondero Met 2.5 mg/1000 mg Tablet is generally not recommended during pregnancy as there is limited information on the safety of linagliptin during this period. Other medicines, like insulin and metformin, are considered safer for diabetes management during pregnancy.

For breastfeeding, Ondero Met 2.5 mg/1000 mg Tablet is also generally not recommended. While metformin can pass into breast milk in small amounts, and some studies suggest a negligible risk of neonatal hypoglycemia, there is not enough information on linagliptin's transfer into breast milk or its effects on breastfed infants. Your doctor will help you decide if the benefits outweigh the risks if you are breastfeeding.

Can Ondero Met 2.5 mg/1000 mg Tablet be taken with other medications?

Yes, Ondero Met 2.5 mg/1000 mg Tablet can interact with other medications. It is crucial to inform your doctor about all prescription, over-the-counter, vitamin, and herbal products you are taking.

Some medications that may interact include:

• Other blood sugar-lowering drugs (e.g., insulin, sulfonylureas) can increase the risk of hypoglycemia.
• Carbonic anhydrase inhibitors (e.g., acetazolamide) may increase the risk of lactic acidosis.
• Certain cationic medicines (e.g., digoxin, amiloride, triamterene) that are eliminated by renal tubular secretion may interact with metformin.
• Strong CYP3A4/P-glycoprotein inducers like rifampin may decrease the effectiveness of linagliptin.
• Corticosteroids, phenothiazines, and thyroid products can affect blood glucose levels.

What precautions should be taken while using Ondero Met 2.5 mg/1000 mg Tablet?

• Kidney and Liver Health: Inform your doctor if you have kidney or liver problems, as dose adjustments may be needed, or the medication may be contraindicated in severe cases due to increased risk of lactic acidosis.
• Alcohol Consumption: Avoid excessive alcohol consumption as it can lower blood sugar and significantly increase the risk of lactic acidosis.
• Surgery/Imaging Tests: You may need to temporarily stop taking this medication before surgery or certain imaging scans (like CT or X-rays using injected dye).
• Pancreatitis: Linagliptin may cause pancreatitis (inflammation of the pancreas). Report sudden stomach pain, nausea, or vomiting to your doctor.
• Dehydration: Dehydration can increase the risk of lactic acidosis.
• Vitamin B12 Deficiency: Long-term use of metformin may lead to a vitamin B12 deficiency.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Do not double doses to make up for a forgotten one.

How should Ondero Met 2.5 mg/1000 mg Tablet be stored?

Store Ondero Met 2.5 mg/1000 mg Tablet at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep it in a closed container, away from heat, moisture, and direct light. Do not store it in moist or damp areas like bathrooms, and ensure the tablets remain dry. Keep this medicine out of the reach of children.