Tenepride M 500 Tablet

Tenepride M 500 Tablet

Tenepride M 500 Tablet is a widely prescribed oral antidiabetic medication manufactured by MICRO LABS LTD. It is primarily used for the effective management of Type 2 Diabetes Mellitus.

• Composition Each tablet contains a combination of two active ingredients:

  • Metformin Hydrochloride: 500 mg
  • Teneligliptin (as Teneligliptin Hydrobromide Hydrate): 20 mg

• Uses Tenepride M 500 Tablet is indicated for the management of Type 2 Diabetes Mellitus in adults. It works by:

  • Improving glycemic control by reducing glucose production in the liver and decreasing its absorption from the intestines.
  • Enhancing insulin sensitivity and increasing insulin levels in the body.
  • Reducing glucagon levels, a hormone that raises blood sugar.
  • It is used as an adjunct to diet and exercise to achieve better blood sugar control and to reduce the risk of serious diabetes complications such as kidney damage, blindness, nerve problems, heart attack, and stroke.
  • It may also be used for insulin resistance in polycystic ovary syndrome (PCOS).

• Dosage and Administration The typical dosage is one tablet once daily, or as advised by a physician. It can be taken with or without food, though taking it with food may help minimize stomach upset. Tablets should be swallowed whole with a glass of water and not crushed, chewed, or broken. Consistent daily timing is recommended for optimal results. The exact dose and duration of treatment are determined by the doctor based on the patient's condition and blood sugar levels.

• Side Effects

  • Common Side Effects: Nausea, vomiting, diarrhea, headache, stomach ache, respiratory infection, low blood sugar (hypoglycemia, especially when used with insulin or sulfonylurea), metallic taste in mouth, constipation, flatulence, altered taste sensations, nasal congestion, and sore throat.
  • Serious Side Effects: Seek immediate medical attention if you experience symptoms of lactic acidosis (e.g., deep or rapid breathing, persistent nausea, vomiting, stomach pain, muscle cramps, severe fatigue, dizziness, cold hands or feet, slow or irregular heartbeat). Other serious effects include severe allergic reactions (hives, swelling of the face, lips, tongue, or throat, difficulty breathing), severe skin rashes, and pancreatitis (sudden and severe abdominal or back pain). Long-term use may lead to Vitamin B12 deficiency.

• Precautions

  • Inform your doctor if you have liver, kidney, or heart problems, severe infection, severe trauma, adrenal insufficiency, bowel obstruction, irregular heartbeat, or if you are due to undergo surgery.
  • It is not recommended for patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, diabetic ketoacidosis, Type 1 diabetes, or known allergy to its components.
  • Caution is advised during pregnancy and breastfeeding; insulin is generally preferred for pregnancy-related diabetes.
  • Avoid or limit alcohol consumption as it increases the risk of lactic acidosis.
  • Regular monitoring of blood sugar levels and kidney function is crucial during treatment.
  • Discuss all other medications you are taking with your doctor, as interactions can occur with drugs like anticoagulants, beta-blockers, and diuretics.

• Storage Store Tenepride M 500 Tablet in a cool and dry place, protected from direct sunlight and moisture. Keep the medicine out of the sight and reach of children. The storage temperature should be below 25°C or 30°C.

What is Tenepride M 500 Tablet used for?

Tenepride M 500 Tablet is primarily used to manage Type 2 Diabetes Mellitus in adults. It is prescribed when diet and exercise alone are insufficient to control blood sugar levels, or when a patient's blood sugar is not adequately controlled with Metformin alone. This medication helps improve overall glycemic control, enhances insulin sensitivity, and reduces the production of glucose in the body, thereby preventing serious complications of diabetes such as kidney damage, blindness, heart attack, or stroke.

How does Tenepride M 500 Tablet work?

Tenepride M 500 Tablet is a combination medicine containing two active ingredients: Metformin and Teneligliptin. Metformin, a biguanide, works by decreasing the amount of glucose produced by the liver and reducing the absorption of glucose from the intestines. It also helps increase the body's sensitivity to insulin. Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, works by increasing the levels of certain natural substances called incretins in the body, which, in turn, stimulate insulin secretion and reduce the levels of glucagon (a hormone that raises blood sugar), particularly after meals. Together, these actions help to effectively lower and control blood sugar levels.

What is the usual dosage for Tenepride M 500 Tablet?

The usual dosage for Tenepride M 500 Tablet is typically one tablet per day. It can be taken with or after food to help minimize stomach upset. It's crucial to follow your doctor's instructions regarding the exact dose and duration of treatment, as this may vary based on your individual medical condition, blood sugar levels, and response to treatment. For optimal results, it should be taken at a fixed time each day.

What are the possible side effects of Tenepride M 500 Tablet?

Common side effects of Tenepride M 500 Tablet may include nausea, vomiting, diarrhea, headache, stomach ache, respiratory infection, and sweating. While often mild and temporary, consult your doctor if these side effects persist or worsen.

More serious, though rare, side effects include lactic acidosis, a potentially life-threatening condition associated with Metformin, whose symptoms can include muscle pain, difficulty breathing, dizziness, unusual tiredness, and stomach pain. Long-term use of Metformin may also lead to Vitamin B12 deficiency. Hypoglycemia (low blood sugar) is also a possible side effect, particularly if the medicine is taken with other antidiabetic medications or if meals are missed.

Is Tenepride M 500 Tablet safe during pregnancy or breastfeeding?

Pregnancy: Tenepride M 500 Tablet should be used with caution during pregnancy. Limited human data is available, and animal studies have shown potential harmful effects on the developing baby. Generally, insulin is preferred for managing diabetes during pregnancy. It should only be used if prescribed by your doctor after carefully weighing the potential benefits against the risks to the fetus.

Breastfeeding: This medicine is generally not recommended for use during breastfeeding. Its components may pass into breast milk and could potentially harm the nursing infant. It is advised to consult your doctor before taking this medicine if you are breastfeeding.

Can Tenepride M 500 Tablet be taken with other medications?

Yes, Tenepride M 500 Tablet can interact with other medications, so it is important to inform your doctor about all medicines you are currently taking, including over-the-counter drugs and herbal supplements. Potential interactions can occur with other antidiabetic agents (e.g., insulin, sulfonylureas), beta-blockers (e.g., propranolol), diuretics (e.g., furosemide), corticosteroids (e.g., prednisolone), and certain medications for heart conditions. You may also be asked to stop taking this medicine temporarily if you need an injection of iodine-containing contrast medium for an X-ray or scan.

What precautions should be taken while on Tenepride M 500 Tablet?

Several precautions should be observed while taking Tenepride M 500 Tablet:

• Alcohol Consumption: Avoid consuming alcohol as it can increase the risk of serious side effects such as lactic acidosis and hypoglycemia.
• Medical Conditions: Inform your doctor if you have a history of kidney, liver, or heart problems, severe infections, dehydration, or pancreatitis.
• Monitoring: Regular monitoring of your blood sugar levels and kidney function is advisable during treatment.
• Lactic Acidosis: Be aware of the symptoms of lactic acidosis (e.g., abdominal pain, muscle cramps, vomiting, severe fatigue, difficulty breathing) and seek immediate medical attention if they occur, especially if you have kidney disease or consume excessive alcohol.
• Vitamin B12 Deficiency: Long-term use may lead to Vitamin B12 deficiency. Your doctor may recommend monitoring B12 levels and prescribing supplements if needed.
• Taking with Food: Taking the tablet with or after meals can help reduce gastrointestinal upset.
• Hypoglycemia: If you experience symptoms of low blood sugar (e.g., cold sweats, shakiness, anxiety), carry and consume sugary food or fruit juice for immediate relief.

What happens if a dose of Tenepride M 500 Tablet is missed?

If you miss a dose of Tenepride M 500 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Tenepride M 500 Tablet be stored?

Tenepride M 500 Tablet should be stored in a cool and dry place, away from direct sunlight, heat, and moisture. Keep it out of the sight and reach of children. The ideal storage temperature is typically below 25°C or 30°C.