LORNIT INFUSION by ZUVENTUS GROMAXX

Name

Brand Name: LORNIT INFUSION Common Name: L-Ornithine L-Aspartate Infusion Concentrate

Composition

Each 10 ml ampoule of LORNIT INFUSION contains 5 grams of L-Ornithine L-Aspartate. The other ingredient is water for injections.

Uses

LORNIT INFUSION is primarily used for the treatment of various liver diseases and conditions associated with impaired liver function. It is prescribed for:

• Hepatic Encephalopathy: Both latent and manifest forms, including pre-coma and coma due to liver failure.
• Acute Liver Failure: To support liver function.
• Hyperammonemia: Elevated ammonia levels in the blood resulting from acute or chronic hepatitis.
• Other Liver Conditions: Such as fatty liver, alcoholic liver damage, jaundice, and liver cirrhosis.

This medicine works by stimulating ammonia detoxification, increasing urea synthesis in the liver, and facilitating glutamine synthesis in the brain and muscle tissues, thereby reducing toxic ammonia levels in the blood.

Dosage and Administration

LORNIT INFUSION is a concentrate for solution for infusion and must be administered intravenously after dilution with conventional intravenous fluids like normal saline, 5% Dextrose, or Ringer's lactate.

• Typical Dose: Up to 4 ampoules (20 grams) per day.
• Severe Cases (Pre-coma or Coma): Up to 8 ampoules (40 grams) within 24 hours, depending on the severity.
• Maximum Infusion Rate: 5 grams of L-Ornithine L-Aspartate (equivalent to one ampoule) per hour.
• Dilution: Typically, 1 ampoule per 100 ml of IV fluid. The dose should not exceed 6 ampoules per 500 ml infusion for venous tolerability.
• Administration: It must not be administered into an artery. It should be administered under the careful supervision of healthcare professionals.

Side Effects

Most side effects are generally transient and may not require discontinuation of treatment; they often resolve with a reduction in dose or infusion rate.

• Common Side Effects: Nausea, vomiting.
• Other Reported Side Effects: Sensation of heat, palpitation, diarrhea, flatulence, stomach pain, pain in the limbs, and allergic skin reaction.

Precautions

• Hypersensitivity: Do not use if hypersensitive to L-Ornithine L-Aspartate.
• Renal Impairment: Contraindicated in cases of severely impaired renal function (e.g., serum creatinine > 3 mg/100 ml).
• Monitoring: At high doses, serum and urine urea levels should be monitored.
• Liver Function: If liver function is substantially impaired, the infusion rate must be adjusted to prevent nausea and vomiting.
• Pregnancy and Lactation: Safety of use during pregnancy and lactation has not been established; administration should generally be avoided unless deemed necessary by a physician after careful assessment of benefits and risks.
• Children: Experience and data on the use of this drug in children are limited.
• Interactions: No known interactions with other medicinal products have been reported.

Storage

Store the medicine below 25°C or 30°C. Keep out of the reach and sight of children.

Lornit Infusion, containing L-Ornithine L-Aspartate, is a medication primarily used in the management of liver diseases. It works by aiding the body's detoxification processes, particularly concerning ammonia.

Here are some frequently asked questions about Lornit Infusion:

What is Lornit Infusion used for?

Lornit Infusion is used to treat latent and manifest hepatic encephalopathy, a condition involving depression or clouding of consciousness due to liver failure. It helps protect the liver from harmful chemical substances, such as free radicals, and enhances its overall function. This medication also helps to improve brain function that may be affected by liver issues.

How does Lornit Infusion work?

Lornit Infusion stimulates ammonia detoxification by increasing urea synthesis in the liver and promoting ammonia detoxification in tissues outside the liver. The L-ornithine L-aspartate active ingredient converts toxic ammonia into non-toxic urea, facilitating its elimination from the body, and supports the urea cycle. It also increases glutamine synthesis in the liver, brain, and muscle tissues, which further helps in reducing ammonia levels.

What is the usual dosage of Lornit Infusion?

The typical recommended dose is up to 4 ampoules (20 grams) per day. In cases of pre-coma or coma, up to 8 ampoules (40 grams) may be administered within 24 hours, depending on the severity of the condition. The maximum infusion rate should not exceed 5 grams (content of one ampoule) per hour, and a maximum concentration of 6 ampoules per 500 ml of infusion solution is recommended. It is administered intravenously by a healthcare professional.

What are the possible side effects of Lornit Infusion?

Common side effects can include nausea (uncommon) and vomiting (rare). These are generally temporary and may resolve by reducing the dose or infusion rate. Other reported side effects include injection site reactions like pain, swelling, and redness, as well as diarrhea, flatulence, abdominal pain, and pain in the limbs. If severe allergic reactions such as pronounced rashes, difficulty breathing, or swelling occur, immediate medical attention should be sought.

Is Lornit Infusion safe during pregnancy or breastfeeding?

The safety of Lornit Infusion during pregnancy and lactation has not been established. Therefore, its administration should generally be avoided in pregnant or breastfeeding individuals. If treatment is deemed necessary, a doctor must carefully assess the benefits and risks, and pregnant or breastfeeding individuals should only use it if advised by their doctor.

Can Lornit Infusion be taken with other medications?

No interactions with other medications are currently known for Lornit Infusion. However, it is always important to inform your doctor about all current medications, including over-the-counter drugs and herbal products, as potential interactions may exist.

What precautions should be taken with Lornit Infusion?

Lornit Infusion should not be used if you are hypersensitive to L-Ornithine L-Aspartate or have severely impaired renal function (e.g., serum creatinine > 3 mg/100 ml). When high doses are used, serum and urine urea levels should be monitored by your doctor. If liver function is significantly impaired, the infusion rate needs to be adjusted individually to prevent side effects like nausea and vomiting. The medication should not be administered into an artery. Regular blood tests to monitor creatinine and urea levels may be recommended during treatment.

What happens if a dose of Lornit Infusion is missed?

Since Lornit Infusion is typically administered by a healthcare professional in a clinical setting, the likelihood of a missed dose is very low. If a dose is missed, it is crucial to consult your doctor for guidance, as missing a dose may impact the treatment's effectiveness.

How should Lornit Infusion be stored?

Lornit Infusion should be stored in a cool and dry place, away from direct sunlight, and typically below 30°C or not above 25°C. It is important to keep the medication out of the reach and sight of children.