Lupinac Tablet (10 Tab)

LUPINAC TABLET by LUPIN LTD.

Name

Brand Name: Lupinac Tablet

Composition

Lupinac Tablet contains a combination of two active ingredients:

• Acetylcysteine (150 mg)
• Taurine (500 mg)

Uses

Lupinac Tablet is primarily used to manage and protect against kidney damage in several conditions:

• Diabetic Kidney Disease (Diabetic Nephropathy): It helps slow the progression of kidney damage caused by high blood sugar levels.
• Paracetamol Poisoning: It is used to manage and protect against severe harm to the liver and kidneys caused by paracetamol overdose.
• Radiocontrast-induced Kidney Damage: It helps prevent kidney damage caused by contrast dyes used during imaging procedures.
• Chronic Kidney Disease (CKD): It supports kidney function and reduces the risk of kidney failure by reducing oxidative stress and inflammation.

Dosage and Administration

• Lupinac Tablet should be taken orally as advised by your physician.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• It can be taken with or without food, though some sources recommend taking it with food.
• The dosage and duration depend on the patient's age, body weight, and specific medical condition, and should not be altered without doctor's advice.

Side Effects

Common Side Effects:

• Nausea
• Vomiting
• Abdominal pain
• Diarrhea
• Rash or itching
• Headache
• Dizziness
• Fever
• Runny nose
• Flushing
• Mouth sores

Most side effects are temporary and resolve upon discontinuation of the medicine. Consult a doctor if any side effects persist or worsen.

Precautions

• Allergies: Do not take if allergic to Acetylcysteine, Taurine, or any other components.
• Pregnancy and Breastfeeding: Use with caution and only if clearly necessary, as limited information is available. Consult your doctor.
• Liver/Kidney Conditions: Exercise caution and inform your doctor if you have pre-existing liver or kidney issues.
• Asthma/Bronchospasm: Use cautiously, as it may trigger bronchospasm due to acetylcysteine.
• Peptic Ulcer Disease: Use with caution as it could potentially aggravate the condition.
• Drug Interactions: Inform your doctor about all ongoing medications, especially antitussives and oral antibiotics (e.g., tetracycline, amoxicillin), as effectiveness may be reduced.
• Skin Reactions: Immediately report severe skin rashes, ulcers, or flu-like symptoms, as it may indicate serious conditions like Stevens-Johnson syndrome.
• Driving/Operating Machinery: May cause dizziness, so caution is advised.

Storage

• Store at room temperature, ideally below 30°C (or below 25°C).
• Protect from excessive light and moisture; keep in a dry place.
• Keep out of reach of children.
• Use before the expiry date.

What is Lupinac Tablet used for?

Lupinac Tablet is primarily used to manage various kidney-related conditions. It is notably effective in treating chronic kidney disease, diabetic nephropathy (diabetic kidney disease), and diabetic kidney damage. It also plays a role in managing paracetamol poisoning and radiocontrast-induced kidney damage. This medication aims to protect the kidneys from damage, slow down the progression of kidney issues, and reduce the risk of kidney failure.

How does Lupinac Tablet work?

Lupinac Tablet is a combination medicine containing Taurine (500mg) and Acetylcysteine (150mg). Both are antioxidants that work synergistically to protect the kidneys. Taurine is an amino acid that helps reduce tissue damage in the kidneys, manages blood glucose levels, and regulates cellular fluid balance. Acetylcysteine acts as an antioxidant by restoring glutathione levels, scavenging free radicals that cause oxidative stress, and exhibiting anti-inflammatory properties. Together, these components safeguard the kidneys from harmful chemicals (free radicals), thereby slowing down kidney cell damage and improving kidney function.

What is the usual dosage of Lupinac Tablet?

The dosage of Lupinac Tablet is determined by your doctor based on your specific condition, age, body weight, and how you respond to the treatment. It is crucial to follow the prescribed dose and duration exactly as advised by your healthcare provider. Generally, it is recommended to swallow the tablet whole with a glass of water, without crushing, chewing, or breaking it. It can be taken with or without food, though some sources suggest taking it with food to maximize effectiveness or reduce nausea.

What are the possible side effects of Lupinac Tablet?

Most side effects of Lupinac Tablet are usually mild and temporary, resolving as your body adjusts to the medication. Common side effects may include nausea, vomiting, abdominal pain, diarrhea, rash, fever, runny nose, skin irritation, throat irritation, flushing, edema, and mouth sores. If any side effects persist or worsen, it is advisable to consult your doctor.

Is Lupinac Tablet safe during pregnancy or breastfeeding?

Lupinac Tablet is generally not recommended for use during pregnancy or breastfeeding unless specifically advised by a doctor. Limited human studies show potential harm to the baby during pregnancy, and it is likely unsafe for breastfeeding mothers as it may pass into breast milk. Your doctor will assess the benefits and potential risks before prescribing it during these periods.

Can it be taken with other medications?

It is important to inform your doctor about all other medications, supplements, or herbal products you are currently taking to prevent potential drug interactions. Lupinac Tablet may interact with certain medications, such as some antibiotics (e.g., tetracycline, erythromycin), potentially reducing their effectiveness. Antitussives (cough suppressants) like codeine might have their effect reduced. Additionally, acetylcysteine in Lupinac can increase the hypotensive effect of vasodilatory medicines like nitroglycerin, increasing the risk of low blood pressure. Activated charcoal may also reduce the absorption of acetylcysteine.

What precautions should be taken?

Before taking Lupinac Tablet, inform your doctor if you have any existing kidney or liver conditions, asthma, lung problems, or a history of allergic reactions to its components. The medication can increase the risk of severe skin rashes like Steven-Johnson syndrome and Lyell syndrome; discontinue use and seek medical advice promptly if skin rashes develop. Caution is advised for patients with peptic ulcer disease as it could potentially aggravate the condition. It is not suitable for children under 12 years old.

What happens if a dose is missed?

If you forget to take a dose of Lupinac Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should it be stored?

Lupinac Tablet should be stored at room temperature, ideally below 30°C. It should be kept in a cool, dry place, protected from excessive light and moisture. Always ensure the medication is kept out of the sight and reach of children. Do not use the tablet after its expiry date.