PYRIGESIC NANO GEL

Name: Pyrigesic Nano Gel (Brand Name)

Composition: Pyrigesic Nano Gel is a topical analgesic that contains a blend of active ingredients:

• Diclofenac Diethylamine (1.16% w/w) (equivalent to Diclofenac 1% w/w) - A non-steroidal anti-inflammatory drug (NSAID) that blocks chemical messengers causing pain and inflammation.
• Linseed Oil (3% w/w) - Possesses anti-inflammatory properties and enhances blood circulation, aiding in quicker healing and better absorption of other ingredients.
• Methyl Salicylate (10% w/w) - Acts as a painkiller, providing a cooling sensation and reducing swelling by improving circulation.
• Menthol (5% w/w) - Delivers a cooling sensation to soothe pain and discomfort in muscles and joints.

Uses: This gel is primarily used for the topical relief of pain and inflammation. It is effective for:

• Acute musculoskeletal pain.
• Joint pain, including that associated with osteoarthritis and rheumatoid arthritis.
• Muscle soreness, sprains, strains, cramps, and contusions.
• Back, neck, and shoulder pain.
• Tendonitis and bursitis.

Dosage and Administration: Pyrigesic Nano Gel is for external (topical) use only.

• Clean and dry the affected area before application.
• Apply a small amount of the gel to the affected area with clean hands or a cotton swab.
• Gently rub it in until absorbed.
• Typically applied 3-4 times daily, or as directed by a doctor.
• Wash hands thoroughly after application, unless the hands are the treated area.
• Avoid showering for at least 1 hour after application.

Side Effects: Common side effects are usually mild and temporary, including:

• Burning, itching, redness, stinging, or dryness at the application site. If side effects persist or worsen, consult a doctor.

Precautions:

• Do not apply to open wounds, broken skin, or mucous membranes (eyes, mouth, nose). In case of accidental contact, rinse thoroughly with water.
• Avoid using external heat or occlusive dressings on treated areas unless advised by a doctor.
• Contraindicated in children below two years of age.
• Children aged 2-12 with viral flu, chickenpox, or viral fever should avoid using it due to the methyl salicylate content, which may induce Reye's Syndrome.
• Individuals with known hypersensitivity or allergies to diclofenac, aspirin, other NSAIDs, or any ingredients in the gel should not use it.
• Topical overdose is unlikely due to low systemic absorption, but it may be harmful if swallowed.

Storage:

• Store in a cool and dry place, away from direct sunlight.
• Keep out of sight and reach of children.
• Store below 30°C.

PYRIGESIC NANO GEL is a topical analgesic manufactured by EAST INDIA PHARMACEUTICAL WORKS LIMITED, designed for pain and inflammation relief. Its "nano" formulation aims for faster and greater skin penetration and absorption, leading to quicker and longer-lasting effects compared to some oral pain relievers.

What is PYRIGESIC NANO GEL used for?

PYRIGESIC NANO GEL is primarily used to relieve acute musculoskeletal pain and joint pain, including pain associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, backache, sprains, strains, cramps, contusions, and sports injuries. It helps reduce pain, swelling, and stiffness, thereby improving joint mobility and overall physical function.

How does PYRIGESIC NANO GEL work?

PYRIGESIC NANO GEL contains a combination of active ingredients: Diclofenac diethylamine, Methyl Salicylate, Linseed Oil, and Menthol. Diclofenac and Methyl Salicylate are non-steroidal anti-inflammatory drugs (NSAIDs) that block the release of chemical messengers responsible for pain and inflammation. Linseed Oil acts as an anti-inflammatory and enhances blood circulation at the application site, which aids in the penetration of Diclofenac. Menthol provides a cooling sensation that first distracts from the pain and then warms the skin, further interfering with pain signal transmission through nerves.

What is the usual dosage of PYRIGESIC NANO GEL?

The gel is for topical (skin surface) use only. It should typically be applied to the affected area 3 to 4 times daily, or as directed by your doctor. Apply a small amount of the gel with clean hands or a piece of clean cotton wool/gauze swab and gently rub it in. Wash your hands thoroughly after application, unless the hands are the affected area.

What are the possible side effects of PYRIGESIC NANO GEL?

Common side effects include burning, itching, redness, stinging, irritation, and dryness at the application site. These side effects are usually mild and short-lived. If they persist or worsen, it is advisable to consult your doctor.

Is PYRIGESIC NANO GEL safe during pregnancy or breastfeeding?

Information regarding the safety of PYRIGESIC NANO GEL during pregnancy and breastfeeding is not readily available. It is crucial to consult your doctor before using this medicine if you are pregnant or breastfeeding, as its safety has not been established.

Can PYRIGESIC NANO GEL be taken with other medications?

While topical medications generally have low systemic absorption, it is advisable to inform your doctor about all medications you are currently taking (including prescription, over-the-counter drugs, and herbal products) to ensure there are no potential interactions. Some sources indicate no reported interactions, while others advise caution if taking blood thinners, aspirin, or other NSAIDs due to potential interactions.

What precautions should be taken when using PYRIGESIC NANO GEL?

PYRIGESIC NANO GEL is for external use only. Avoid contact with eyes, mouth, nose, mucous membranes, or open wounds/damaged skin. If accidental contact occurs, rinse the area thoroughly with water. Do not apply external heat or occlusive dressings to the treated area unless advised by a doctor. Individuals with a known allergy to diclofenac, aspirin, other NSAIDs, or any components of the gel should not use it. It is contraindicated in children below two years of age, and caution should be exercised in older children (2-12 years), particularly those with viral flu, chickenpox, or viral fever, as it contains methyl salicylate which may induce Reye's Syndrome.

What happens if a dose of PYRIGESIC NANO GEL is missed?

Since PYRIGESIC NANO GEL is a topical medication, the concept of a "missed dose" is less critical than for oral medications. If you forget to apply it as scheduled, apply it as soon as you remember, or simply continue with your next scheduled application. Do not apply extra gel to make up for a missed dose.

How should PYRIGESIC NANO GEL be stored?

PYRIGESIC NANO GEL should be stored in a cool and dry place, away from direct sunlight, ideally between 10ºC and 25ºC, or below 30ºC. Keep it out of the sight and reach of children.