Diprobate G Plus 30 Gm Cream

DIPROBATE G PLUS 30 GM CREAM

DIPROBATE G PLUS Cream is a topical medication manufactured by Sun Pharmaceutical Industries Ltd., formulated to address various inflammatory skin conditions that are complicated by or susceptible to bacterial infections.

Composition

DIPROBATE G PLUS Cream contains a combination of three active ingredients:

• Betamethasone Dipropionate (0.05% w/w): A potent synthetic corticosteroid that provides anti-inflammatory, anti-itching, and vasoconstrictive actions by blocking the production of chemical messengers (prostaglandins) that cause redness, swelling, and itching.
• Gentamicin Sulphate (0.1% w/w): A broad-spectrum aminoglycoside antibiotic that works by inhibiting bacterial protein synthesis, thereby killing or preventing the growth of susceptible bacteria on the skin.
• Zinc Sulphate (0.5% w/w): Possesses mild drying, anti-inflammatory, and antiseptic properties, aiding in wound healing and promoting skin repair.
• Chlorocresol (0.1% w/w): Included as an antimicrobial preservative in the cream.

Uses

DIPROBATE G PLUS Cream is primarily used for the management of inflammatory skin conditions that are prone to bacterial infections. These conditions include:

• Bacterial skin infections
• Eczema (inflamed, itchy, cracked, and rough skin patches)
• Psoriasis (uneven or bumpy red patches covered with white scales)
• Dermatitis (itchy inflammation of the skin), including infected eczematous dermatitis, atopic dermatitis with bacterial superinfection, and contact dermatitis.
• Other corticosteroid-responsive dermatoses when complicated by secondary bacterial infection. It helps alleviate itching, redness, and swelling associated with these conditions.

Dosage and Administration

DIPROBATE G PLUS Cream is for external use only.

• Application: Clean and dry the affected area before application. Apply a thin layer of the cream to the affected skin and gently rub it in until absorbed.
• Frequency: Typically applied twice daily, in the morning and at night, or as directed by a doctor.
• Duration: Use for the duration prescribed by your doctor. Do not use for more than 5 days in children or when applied on the face, unless advised by a doctor.
• Hygiene: Wash hands thoroughly before and after applying the cream, unless the hands are the area being treated.

Side Effects

Common side effects at the application site may include:

• Burning sensation
• Itching
• Skin irritation
• Dry skin or peeling of the skin
• Redness
• Acne or acneiform eruptions
• Changes in skin color (hypopigmentation)
• Folliculitis (inflammation of hair follicles)
• Hypertrichosis (excessive hair growth)
• Perioral dermatitis (rash around the mouth)

Most of these side effects are temporary and usually resolve over time. However, if they persist or worsen, consult your doctor. Serious allergic reactions (e.g., rash, hives, difficulty breathing, swelling) are rare but require immediate medical attention.

Precautions

• Allergies: Do not use if allergic to Betamethasone, Gentamicin, Zinc, Chlorocresol, or any other ingredients.
• Contact: Avoid contact with eyes, mouth, nose, vagina, or other mucous membranes. Rinse with water immediately if accidental contact occurs.
• Broken Skin: Do not apply on open wounds, broken skin, or highly irritated skin unless advised by a physician.
• Bandages: Do not cover the treated area with bandages or airtight dressings unless specifically instructed by your doctor, as this may increase systemic absorption.
• Flammability: Avoid smoking or going near naked flames as fabrics (bedding, clothing, dressings) in contact with the cream can catch fire easily.
• Pregnancy and Breastfeeding: Consult a doctor before using if pregnant or breastfeeding.
• Children: Use with caution in children, and typically not recommended for children under one year old. Avoid prolonged use in children or on the face to prevent side effects like skin thinning.
• Pre-existing Conditions: Inform your doctor if you have other skin infections (viral, fungal, tubercular), diabetes, skin atrophy, striae, telangiectasia, rosacea, perioral dermatitis, glaucoma, cataracts, or ear/eye infections.
• Prolonged Use: Avoid prolonged use, as it may lead to skin thinning and other side effects.

Storage

Store DIPROBATE G PLUS Cream at room temperature (below 30°C), protected from moisture and heat. Keep it out of the sight and reach of children and pets.

What is Diprobate G Plus Cream used for?

Diprobate G Plus Cream is a topical medication primarily used to treat various bacterial skin infections and inflammatory skin conditions that are susceptible to bacterial involvement. These conditions include eczema, psoriasis, and dermatitis, where it helps alleviate swelling, itching, and redness.

How does Diprobate G Plus Cream work?

This cream works through the combined action of its three active ingredients:

• Betamethasone: A corticosteroid that reduces inflammation, swelling, redness, and itching by blocking the production of certain chemical messengers in the body.
• Gentamicin: An aminoglycoside antibiotic that prevents bacteria from synthesizing essential proteins, thereby fighting bacterial growth and infection.
• Zinc Sulfate: Acts as an antiseptic and astringent, helping to prevent microbial growth, promote wound healing, and repair skin.

What is the usual dosage of Diprobate G Plus Cream?

Apply a thin layer of the cream to the affected skin area and gently rub it in until absorbed, typically two to three times a day, or as directed by your doctor. It is important to wash your hands before and after applying the cream. The duration of treatment varies, but it is generally not recommended for more than two weeks unless specifically advised by a healthcare professional.

What are the possible side effects of Diprobate G Plus Cream?

Common side effects at the application site include burning sensation, itching, irritation, redness, dryness, skin peeling, cracking, acne, or changes in skin color. These effects are usually mild and temporary. If you experience any severe allergic reactions such as rashes, hives, swelling, or difficulty breathing, seek immediate medical attention. Prolonged use can sometimes lead to skin thinning, folliculitis, or hypopigmentation.

Is Diprobate G Plus Cream safe during pregnancy or breastfeeding?

Pregnancy: There is limited data on the use of Diprobate G Plus Cream during pregnancy. Caution is advised, and you should consult your doctor before using this cream. It should only be used if considered essential after assessing the potential benefits against the risks, and large skin areas or prolonged durations should be avoided.

Breastfeeding: Limited data is available regarding its use during breastfeeding. It is advisable to consult your doctor before using this cream. If prescribed, avoid applying it on the breast or areas near the breast, or over large areas of the body for a prolonged duration.

Can Diprobate G Plus Cream be taken with other medications?

As a topical medication, Diprobate G Plus Cream is less likely to interact with systemic medications. However, it is important to inform your doctor about all other medications you are currently taking, especially other topical creams or ointments for similar or different skin conditions.

What precautions should be taken while using Diprobate G Plus Cream?

This cream is for external use only. Avoid contact with your eyes, nose, mouth, other mucous membranes, or open wounds. If accidental contact occurs, rinse thoroughly with water. Do not cover the treated area with bandages or airtight dressings unless specifically instructed by your doctor, as this can increase the risk of side effects. Avoid prolonged use, especially on the face, in skin folds, or on large areas, as this can lead to skin thinning or other adverse effects. This medicine is not recommended for children less than one year old, and children under 12 years of age should not use it for more than five days. Inform your doctor if you have any pre-existing conditions like fungal or viral skin infections, tuberculosis, or diabetes. Discontinue use and consult your doctor if irritation, sensitivity, or worsening of your condition occurs.

What happens if a dose of Diprobate G Plus Cream is missed?

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply a double dose to compensate for the missed one.

How should Diprobate G Plus Cream be stored?

Store Diprobate G Plus Cream at room temperature, protected from moisture and heat. Keep it out of the reach and sight of children and pets.