IVANODE 5 MG TABLET

Name

Brand Name: IVANODE 5 MG TABLET Common Name: Ivabradine 5 mg Tablet

Composition

IVANODE 5 MG TABLET contains Ivabradine (5 mg) as its active ingredient.

Uses

IVANODE 5 MG TABLET is primarily used to manage two specific heart conditions:

• Chronic Stable Angina Pectoris (Chest Pain): It is prescribed for adults to reduce the frequency and severity of heart-related chest pain, especially for those who cannot tolerate or are contraindicated to use beta-blockers. It works by slowing the heart rate, thereby reducing the heart's oxygen demand and improving blood flow to the heart muscle.
• Chronic Heart Failure: It is used in adults, particularly those classified under New York Heart Association (NYHA) class II-IV with systolic dysfunction, to improve heart function and reduce the risk of hospitalization. It helps the heart pump blood more efficiently by lowering the heart rate.

Dosage and Administration

The typical starting dosage for adults is 5 mg twice daily with meals. Depending on the patient's response, the dosage may be increased to a maximum of 7.5 mg twice daily. The tablet should be swallowed whole with a glass of water, without crushing or chewing. It is important to take the medicine with food at a consistent time each day to ensure optimal absorption and reduce stomach upset. Do not stop taking this medicine without consulting your doctor.

Side Effects

Common side effects of IVANODE 5 MG TABLET include:

• Luminous phenomena (temporary enhanced brightness in vision, also known as phosphenes), which may occur within the initial 2 months of treatment and usually go away gradually.
• Bradycardia (excessively slow heart rate), particularly during the initial 2-3 months of treatment.
• Blurred vision.
• Headache.
• Dizziness.
• Nausea.
• Constipation.
• Diarrhoea.
• Fatigue.
• Uncontrolled blood pressure (can also be high blood pressure).
• Irregular heartbeats or atrial fibrillation.

Serious side effects like fainting or significant changes to heart rate may require urgent medical attention.

Precautions

• Contraindications: IVANODE 5 MG TABLET should not be used if you are allergic to ivabradine, have severe liver disease, a low resting heart rate (bradycardia), heart rhythm disorders (arrhythmia), very low blood pressure, or recently worsened heart failure. It is also not recommended if your heart rate is controlled by a pacemaker.
• Pregnancy and Breastfeeding: IVANODE 5 MG TABLET is generally not recommended during pregnancy or while breastfeeding.
• Drug Interactions: Inform your doctor about all medications you are taking, especially antifungals (e.g., ketoconazole, itraconazole), certain antibiotics (e.g., clarithromycin), HIV medications (e.g., ritonavir, nelfinavir), and some medicines for high blood pressure and heart diseases (e.g., diltiazem, verapamil). Grapefruit juice should be avoided as it may alter the effect of the medicine.
• Driving and Operating Machinery: This medicine may cause dizziness or blurred vision. Avoid driving or operating machinery until you know how it affects you.
• Other Warnings: Caution is advised if you have moderate liver impairment, kidney problems, electrolyte disturbances, or eye diseases. Regular monitoring of heart rate and blood pressure is recommended.

Storage

Store IVANODE 5 MG TABLET in a cool, dry place where the temperature stays below 25°C or 30°C. Keep it protected from moisture and direct sunlight. Always keep it out of reach of children.

Frequently Asked Questions about IVANODE 5 MG TABLET

What is IVANODE 5 MG TABLET used for?

IVANODE 5 MG TABLET is primarily used to treat chronic stable angina (chest pain caused by reduced blood flow to the heart) and chronic heart failure in adults. It is especially useful for patients who cannot tolerate or are contraindicated to use beta-blockers.

How does IVANODE 5 MG TABLET work?

IVANODE 5 MG TABLET contains ivabradine, which works by selectively inhibiting the cardiac pacemaker If current in the sinus node. This action slows down the heart rate, reducing the heart's oxygen demand and improving the balance of oxygen supply and demand.

What is the usual dosage for IVANODE 5 MG TABLET?

The typical starting dosage for adults is 5 mg twice daily, taken with meals. Depending on the patient's response and the condition being treated, the dosage may be adjusted by a doctor, potentially increasing to a maximum of 7.5 mg twice daily after 3-4 weeks.

What are the possible side effects of IVANODE 5 MG TABLET?

Common side effects can include luminous phenomena (temporary enhanced brightness in vision), bradycardia (excessively slow heart rate), blurred vision, headache, dizziness, nausea, constipation, and diarrhea. Some more serious side effects, though less common, can include irregular or rapid heartbeat (atrial fibrillation), first-degree atrioventricular block, and ventricular extrasystoles.

Is IVANODE 5 MG TABLET safe during pregnancy or breastfeeding?

IVANODE 5 MG TABLET is generally not recommended during pregnancy as it may cause harm to the developing fetus. Women of childbearing potential should use effective contraception during treatment. Breastfeeding is also not recommended while taking this medicine, and it's crucial to discuss alternatives with your doctor.

Can IVANODE 5 MG TABLET be taken with other medications?

IVANODE 5 MG TABLET can interact with several medications. Concomitant use with strong CYP3A4 inhibitors like ketoconazole, itraconazole (antifungals), clarithromycin (antibiotic), ritonavir (HIV medication), diltiazem, and verapamil (antihypertensives) is generally not recommended as they can significantly increase ivabradine levels, potentially leading to increased side effects. Caution is also advised with certain water pills (diuretics), quinidine, amiodarone, pimozide, pentamidine, beta-blockers, calcium channel blockers, and digoxin. Always inform your doctor about all current medications to avoid potential interactions.

What precautions should be taken while using IVANODE 5 MG TABLET?

Avoid consuming grapefruit juice while taking IVANODE 5 MG TABLET as it can increase the medicine's levels in the body. If you experience dizziness or visual disturbances (like temporary bright flashes), avoid driving or operating machinery. Regular monitoring of heart rate and blood pressure is important. Do not use if you have severe liver disease, a low resting heart rate, or a heart rhythm disorder, very low blood pressure, or recently worsening heart failure.

What happens if a dose of IVANODE 5 MG TABLET is missed?

If you miss a dose of IVANODE 5 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should IVANODE 5 MG TABLET be stored?

IVANODE 5 MG TABLET should be stored in a cool, dry place at room temperature (below 25°C or 30°C), protected from direct sunlight and excessive moisture. Keep it out of the reach and sight of children and pets. Ensure the medicine is used before its expiry date.