Glucoryl M 0.5 Mg Tablet (15 Tab)

GLUCORYL M 0.5 MG TABLET

GLUCORYL M 0.5 MG TABLET is a combination antidiabetic medication manufactured by Alkem Laboratories Ltd., used for the management of type 2 diabetes mellitus.

• Name:

  • Brand Name: GLUCORYL M 0.5 MG TABLET
  • Common Name: Glimepiride and Metformin Hydrochloride Tablets

• Composition: Each tablet contains:

  • Glimepiride: 0.5 mg
  • Metformin Hydrochloride (as sustained release): 500 mg

• Uses: GLUCORYL M 0.5 MG TABLET is primarily prescribed for adults with type 2 diabetes mellitus. It is indicated when diet, exercise, and a single antidiabetic agent do not provide adequate blood sugar control. This medicine helps to lower blood glucose levels and reduce the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, limb amputations, and cardiovascular risks.

• Dosage and Administration: This medicine should be taken orally, usually once daily, with a full meal, preferably with the first meal of the day or in the evening. Tablets should be swallowed whole with some liquid and should not be chewed, crushed, or broken. The dosage is determined by a healthcare professional based on individual blood and urinary glucose determinations and may be adjusted over time.

• Side Effects: Common side effects may include:

  • Nausea, vomiting, diarrhea
  • Abdominal pain/stomach discomfort
  • Headache, dizziness
  • Hypoglycemia (low blood sugar levels)
  • Metallic taste in the mouth
  • Altered taste

  Serious but rare side effects include:

  • Lactic acidosis (a medical emergency caused by increased levels of lactic acid in the blood)
  • Vitamin B12 deficiency with long-term use
  • Inflammation of the liver (jaundice)
  • Severe allergic reactions

• Precautions:

  • Contraindications: GLUCORYL M 0.5 MG TABLET is contraindicated in patients with type 1 diabetes mellitus, diabetic ketoacidosis, severe kidney or liver impairment, severe infections, dehydration, heart or lung failure, recent myocardial infarction, or known hypersensitivity to glimepiride, metformin, other sulfonylureas, sulfonamides, or any excipients. It is also not recommended for use in children.
  • Pregnancy and Breastfeeding: It is generally contraindicated during pregnancy as it may harm the unborn baby, and also during breastfeeding as active ingredients may pass into breast milk.
  • Alcohol Consumption: Avoid excessive alcohol intake while on this medication, as it increases the risk of lactic acidosis and can also increase the risk of hypoglycemia.
  • Kidney and Liver Disease: Use with caution in patients with kidney or liver disease. Dose adjustments may be necessary, and it is not recommended in severe cases.
  • Driving and Using Machines: Blood sugar fluctuations (hypoglycemia or hyperglycemia) can affect the ability to drive or operate machinery. Patients should be aware of their body's response before performing such activities.
  • Drug Interactions: Inform your doctor about all other medications you are taking, as interactions can occur with beta-blockers, salicylates, and thiazides, potentially altering blood sugar levels.

• Storage: Store the medicine in a closed container at room temperature, below 30°C, away from heat, moisture, and direct sunlight. Keep it out of the reach and sight of children.

GLUCORYL M 0.5 MG TABLET is a combination medicine primarily used to manage type 2 diabetes mellitus in adults. It contains two active ingredients: Glimepiride and Metformin.

Here are some frequently asked questions about GLUCORYL M 0.5 MG TABLET:

What is GLUCORYL M 0.5 MG TABLET used for?

GLUCORYL M 0.5 MG TABLET is used to manage type 2 diabetes mellitus in adults. It is typically prescribed when diet, exercise, and a single antidiabetic medication are not sufficient to control blood sugar levels. This medication also helps reduce the risk of serious diabetes-related complications such as kidney damage, blindness, nerve problems, limb amputations, sexual dysfunction, and cardiovascular risks.

How does GLUCORYL M 0.5 MG TABLET work?

GLUCORYL M 0.5 MG TABLET combines the actions of Glimepiride and Metformin to provide a dual approach to blood sugar control.

• Glimepiride belongs to the sulfonylurea class. It primarily works by stimulating the beta cells in the pancreas to produce and release more insulin, a hormone that helps lower blood sugar. It also enhances the sensitivity of body tissues to insulin.
• Metformin belongs to the biguanide class. It reduces the amount of glucose produced by the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin, allowing cells to utilize blood sugar more effectively.

What is the usual dosage for GLUCORYL M 0.5 MG TABLET?

GLUCORYL M 0.5 MG TABLET is typically taken orally once a day with food, usually with the first meal of the day. Your doctor will determine the appropriate dose for you, which may be adjusted based on your blood sugar levels and response to the treatment. It is important to take the tablet whole without chewing, crushing, or breaking it.

What are the possible side effects of GLUCORYL M 0.5 MG TABLET?

Common side effects may include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, abdominal pain, metallic taste in the mouth, headache, dizziness, and altered taste.

Serious but rare side effects can include lactic acidosis (a buildup of lactic acid in the blood) and, with long-term use, a deficiency in Vitamin B12.

Symptoms of low blood sugar (hypoglycemia) can include sweating, dizziness, headache, shaking, irritability, hunger, a fast heart rate, and feeling anxious or shaky. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, a feeling of coldness in the arms and legs, difficulty breathing, nausea, vomiting, and stomach pain. If you experience severe or persistent side effects, contact your doctor immediately.

Is GLUCORYL M 0.5 MG TABLET safe during pregnancy or breastfeeding?

GLUCORYL M 0.5 MG TABLET is generally not recommended during pregnancy as it may be unsafe and could harm the unborn baby. It should only be used if the potential benefits clearly outweigh the risks, and under strict medical supervision.

It is also generally advised to avoid this medication while breastfeeding because both glimepiride and metformin can pass into breast milk and may cause adverse effects in the baby. Your doctor will advise whether to stop the medication or discontinue nursing.

Can GLUCORYL M 0.5 MG TABLET be taken with other medications?

GLUCORYL M 0.5 MG TABLET can interact with various other medications. It is crucial to inform your doctor about all prescription, over-the-counter, herbal, and vitamin supplements you are taking to avoid potential interactions.

• Increased risk of low blood sugar: Medications such as beta-blockers (e.g., propranolol), salicylates (e.g., aspirin), and other antidiabetic medicines can enhance the glucose-lowering effect, leading to a higher risk of hypoglycemia.
• Increased risk of lactic acidosis: Alcohol and certain cationic drugs can increase the risk of lactic acidosis.
• Decreased effectiveness: Thiazide diuretics (e.g., hydrochlorothiazide) may decrease the glucose-controlling effect of this medication.

Other drugs that may interact include certain antibiotics, calcium channel blockers, antacids, HIV/AIDS medications, heart medications, anticancer drugs, antifungals, and anticonvulsants.

What precautions should be taken while using GLUCORYL M 0.5 MG TABLET?

• Alcohol: Avoid consuming alcohol while taking this medicine, as it can significantly increase the risk of low blood sugar and lactic acidosis.
• Medical Conditions: This medicine is not suitable for individuals with type 1 diabetes mellitus, diabetic ketoacidosis, severe kidney or liver disease, or acute heart problems. Use with caution in patients with mild to moderate liver or kidney impairment, and dose adjustments may be necessary.
• Monitoring: Regular monitoring of blood sugar levels is essential. Your doctor may also monitor your kidney and liver function, and Vitamin B12 levels during long-term treatment.
• Hypoglycemia Awareness: Be aware of the symptoms of low blood sugar and always carry a fast-acting source of glucose (like glucose tablets or fruit juice) to treat it.
• Driving and Machinery: This medicine may cause dizziness or drowsiness, potentially affecting your ability to drive or operate machinery. Exercise caution until you know how the medication affects you.
• Diet and Exercise: It is crucial to follow a balanced diet and engage in regular physical activity as advised by your healthcare provider, as these are integral to managing diabetes effectively.
• Surgery/Tests: Inform your doctor if you are scheduled for surgery or any diagnostic imaging tests involving iodinated contrast materials.

What happens if a dose of GLUCORYL M 0.5 MG TABLET is missed?

If you miss a dose of GLUCORYL M 0.5 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Missing a dose can lead to high blood sugar levels. If you frequently miss doses or have concerns, consult your doctor.

How should GLUCORYL M 0.5 MG TABLET be stored?

Store GLUCORYL M 0.5 MG TABLET in a cool, dry place, typically below 30°C. Keep the medicine in its original container, tightly closed, and protect it from light and moisture. Always keep it out of the reach of children. Do not use the medicine beyond its expiry date.