Endobloc T Kit ( 10+10 Tab)

ENDOBLOC T KIT (10+10 TAB) by CIPLA LTD.

Name

Brand Name: ENDOBLOC T KIT, Endobloc T Combipack, Endoblock T Kit Combipack.

Composition

ENDOBLOC T KIT is a combination medication containing two active ingredients:

• Ambrisentan (5 mg)
• Tadalafil (20 mg)

Uses

ENDOBLOC T KIT is prescribed for the treatment of Pulmonary Arterial Hypertension (PAH), specifically WHO Group 1 PAH. It works by relaxing blood vessels in the lungs, aiming to enhance pulmonary artery function, improve exercise capacity, and delay clinical worsening by reducing pulmonary vascular resistance.

Dosage and Administration

The recommended starting dose typically includes ambrisentan 5mg and tadalafil 20mg, taken once daily. It should be ingested orally, with or without food. For optimal efficacy, maintain consistency in timing, taking it regularly at evenly spaced intervals, preferably at the same time each day. Tablets should be swallowed whole and not broken, chewed, or crushed. Do not discontinue the medication without consulting a physician, as this may worsen the condition. Dosage adjustments should only be made by a healthcare professional based on tolerability and clinical response.

Side Effects

Common Side Effects:

• Headache
• Peripheral edema (swelling in hands/feet)
• Nasal congestion
• Cough, bronchitis
• Anemia (low red blood cell count)
• Indigestion
• Flushing (reddening of the skin)
• Dizziness
• Abdominal pain, constipation
• Palpitations, chest pain
• Upper respiratory tract infection
• Vomiting, ringing in the ears, abnormal liver function.

Serious Side Effects (consult a doctor immediately if experienced):

• Severe hypotension (low blood pressure)
• Syncope (loss of consciousness)
• Liver damage or increased liver enzyme levels
• Sudden loss of vision
• Priapism (prolonged, painful erection)
• Allergic reactions.

Precautions

• Contraindications: ENDOBLOC T KIT is contraindicated in patients with hypersensitivity to ambrisentan or tadalafil, severe liver impairment, idiopathic pulmonary fibrosis, and during pregnancy due to potential fetal harm. It should also be avoided by breastfeeding mothers and patients taking strong CYP3A4 inhibitors (e.g., ritonavir, ketoconazole), nitrates, or riociguat, due to the risk of severe hypotension. Patients with a history of heart failure, low blood pressure, stroke, heart blockage, or certain eye problems (like retinitis pigmentosa) should not use this medicine.
• Monitoring: Regular monitoring of liver enzymes and hemoglobin levels is crucial during treatment.
• Pregnancy and Contraception: Women of childbearing potential must have a negative pregnancy test before starting treatment and use two reliable methods of contraception during treatment and for at least one month after stopping the medication.
• Alcohol: Alcohol consumption should be avoided as it may increase the risk of low blood pressure.
• Driving: The medication may cause dizziness or weakness due to low blood pressure, so avoid driving or operating machinery until you know how it affects you.
• Pediatric Use: Not recommended for children under 18 years of age.
• Other Conditions: Caution is advised in patients with kidney disease, anemia, edema, history of heart failure, or specific penile deformities.

Storage

Store ENDOBLOC T KIT below 30°C in a cool, dry place. Keep it away from direct sunlight and out of the reach of children. Do not freeze the medicine.

What is Endobloc T Kit used for?

Endobloc T Kit, manufactured by Cipla Ltd., is primarily used for the treatment of pulmonary arterial hypertension (PAH). PAH is a condition characterized by high blood pressure in the arteries that transport blood from the heart to the lungs. This medication helps improve exercise capacity and quality of life while also delaying disease progression. It has also been mentioned for use in erectile dysfunction.

How does Endobloc T Kit work?

Endobloc T Kit is a combination of two active ingredients: Ambrisentan and Tadalafil. Ambrisentan is an endothelin receptor antagonist, which works by inhibiting the action of endothelin, a natural substance that narrows blood vessels and increases blood pressure. By blocking this action, Ambrisentan relaxes and widens the blood vessels in the lungs, reducing blood pressure and improving blood flow. Tadalafil is a phosphodiesterase-5 (PDE5) inhibitor that relaxes the blood vessels in the lungs, enhancing blood flow to the lungs and reducing the strain on the heart.

What is the usual dosage of Endobloc T Kit?

Endobloc T Kit should be taken exactly as directed by your physician. Typically, the tablets are taken orally, with or without food. They should be swallowed whole and not crushed, chewed, or opened. Your doctor will determine the correct dosage and duration based on factors such as age, body weight, and the specific disease condition. The recommended starting dose often includes Ambrisentan 5mg and Tadalafil 20mg once daily. It is important to take it at the same time every day for consistent efficacy.

What are the possible side effects of Endobloc T Kit?

Common side effects of Endobloc T Kit can include headache, nausea, flushing (redness of the skin), nasal congestion, abdominal pain, constipation, chest pain, ringing in the ears, abnormal liver function, back pain, muscle pain, and pain in the extremities. More serious side effects, though less common, can include oedema (swelling, especially in hands and feet), anemia (low red blood cell count), hypotension (low blood pressure), allergic reactions, sudden loss of vision, and priapism (prolonged or painful erection). If any side effects persist or worsen, you should consult your doctor.

Is Endobloc T Kit safe during pregnancy or breastfeeding?

No, Endobloc T Kit is considered unsafe for use during pregnancy. It may cause harm to an unborn baby, and human and animal studies have shown significant adverse effects on the fetus. Women of childbearing potential are advised to use effective contraception while taking this medication. It is also generally not recommended to use Endobloc T Kit while breastfeeding, as it is likely unsafe for the infant. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can Endobloc T Kit be taken with other medications?

Endobloc T Kit can interact with other medications. It is crucial to inform your doctor about all prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you are taking or have taken. Specific medications like Riociguat (a guanylate cyclase stimulator), Ritonavir, Ketoconazole, and alpha-blockers may interact with Endobloc T Kit, potentially causing undesirable side effects or severe low blood pressure. Concomitant administration with organic nitrates or medicines containing nitrates can lead to severe hypotensive effects.

What precautions should be taken while using Endobloc T Kit?

Several precautions should be taken:

• Liver and Kidney Conditions: Avoid this medicine if you have severe liver conditions. Patients with kidney or mild to moderate liver disease may require dose adjustments or close monitoring.
• Blood Pressure: Inform your doctor if you have low blood pressure or a history of heart failure.
• Vision/Hearing: Notify your doctor if you have a history of vision loss in one eye or experience sudden vision or hearing loss.
• Alcohol: Avoid alcohol consumption as it can further lower blood pressure and increase the risk of side effects like dizziness and headache.
• Driving: The medication can cause dizziness and a drop in blood pressure, so caution is advised when driving or operating machinery.
• Other Conditions: Disclose any history of lung conditions (like idiopathic pulmonary fibrosis), anemia, edema (fluid retention), penis deformation, prolonged erection (priapism), or certain cancers (leukemia, multiple myeloma).
• Children: Endobloc T Kit is not recommended for use in children under 18 years of age.

What happens if a dose of Endobloc T Kit is missed?

If you miss a dose of Endobloc T Kit, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one.

How should Endobloc T Kit be stored?

Endobloc T Kit should be stored in a cool, dry place, away from direct sunlight, heat, and moisture. Keep it out of reach of children and pets.