Here is a detailed product description for HUMINSULIN 30/70 100 IU INJECTION 3 ML CARTRIDGE (5 CARTRIDGE) by LUPIN LTD.

HUMINSULIN 30/70 100 IU INJECTION 3 ML CARTRIDGE

• Name: Huminsulin 30/70. This product is a biphasic isophane insulin injection. While similar formulations like Humulin 30/70 are available from other manufacturers, this description pertains to HUMINSULIN 30/70 from Lupin Ltd.
• Composition: Each ml of the suspension contains 100 International Units (IU) of human insulin, consisting of 30% soluble human insulin (rapid-acting) and 70% isophane human insulin (intermediate-acting).
• Uses: HUMINSULIN 30/70 is prescribed for the treatment of diabetes mellitus in both adults and children, including:
  • Type 1 Diabetes Mellitus (insulin-dependent).
  • Type 2 Diabetes Mellitus, particularly when diet and oral hypoglycemic agents are insufficient for blood sugar control.
  • Initial stabilization of diabetes in patients with conditions such as diabetic ketoacidosis, hyperosmolar non-ketotic syndrome, and during periods of stress (e.g., severe infections, major surgery).
  • Gestational diabetes. This medication works by facilitating the uptake of glucose into muscle and fat cells and inhibiting glucose production by the liver, thereby helping to maintain consistent blood sugar control.
• Dosage and Administration:
  • HUMINSULIN 30/70 is administered via subcutaneous injection into areas such as the upper arms, thighs, buttocks, or abdomen.
  • Injection sites should be rotated to prevent lipodystrophy (thickening or pitting of the skin).
  • The injection should typically be given 15 to 30 minutes before a meal containing carbohydrates.
  • Before use, rotate the cartridge gently several times in your palms to ensure the insulin is uniformly mixed and appears cloudy or milky. Do not use if clumps are present or if the solid remains at the bottom.
  • Dosage is highly individualized and determined by a healthcare professional based on the patient's blood glucose levels and specific needs.
  • This formulation should not be administered intravenously.
  • Never share an injection pen, cartridge, or syringe with another person, even if the needle has been changed, to prevent the transmission of infections.
• Side Effects:
  • Common Side Effects: Hypoglycemia (low blood sugar) is the most frequent and potentially serious side effect, characterized by symptoms like headache, hunger, sweating, pallor, irritability, dizziness, shakiness, or trouble concentrating. Other common side effects include injection site reactions (pain, redness, swelling, itching), lipodystrophy, weight gain, oedema (swelling in hands or feet), rash, nausea, vomiting, and diarrhea.
  • Serious Side Effects: Seek immediate medical attention if experiencing signs of a severe allergic reaction (widespread rash or blisters, swelling of the face/tongue/throat, difficulty breathing, wheezing, rapid pulse) or severe hypoglycemia leading to unconsciousness or seizures. Low blood potassium (hypokalemia) is also a possible serious side effect.
• Precautions:
  • Do not use HUMINSULIN 30/70 if you are experiencing hypoglycemia or are allergic to insulin or any of its components.
  • Always consult your doctor before changing your insulin dose or stopping the medication.
  • Regularly monitor your blood sugar levels and report the results to your healthcare provider.
  • Use with caution in patients with kidney or liver problems, as dose adjustments may be necessary.
  • Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding, as insulin requirements may change.
  • Alcohol consumption can significantly affect blood sugar levels; it is advisable to avoid or limit alcohol intake.
  • As HUMINSULIN 30/70 can cause dizziness or blurred vision, exercise caution when driving or operating machinery.
  • Switching to a different type or brand of insulin should only be done under strict medical supervision.
  • Concomitant use with certain oral diabetes medicines, such as pioglitazone (thiazolidinediones), may increase the risk of fluid retention and heart failure, particularly in patients with pre-existing risk factors.
• Storage:
  • Unopened cartridges: Store in a refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze, and do not use if it has been frozen. Protect from direct sunlight and excessive heat.
  • Opened (in-use) cartridges: Can be stored at room temperature (below 30°C or 25°C, depending on the specific product information) for up to 28 days. Do not store the injection pen with a needle attached. Discard the cartridge 28 days after first use, even if some insulin remains.

Frequently Asked Questions about HUMINSULIN 30/70

What is Huminsulin 30/70 used for?

Huminsulin 30/70 is used to treat both Type 1 and Type 2 Diabetes Mellitus. It helps to regulate blood sugar levels in adults and children with diabetes.

How does Huminsulin 30/70 work?

Huminsulin 30/70 is a combination of two types of human insulin: 30% soluble insulin (short-acting) and 70% insulin isophane (intermediate-acting). It works by stimulating peripheral glucose uptake by skeletal muscle and fat cells and inhibiting the liver's production of sugar. This helps to ensure rapid and consistent blood sugar control throughout the day.

What is the usual dosage for Huminsulin 30/70?

The dosage of Huminsulin 30/70 is highly individualized and determined by your doctor based on your specific needs, blood glucose monitoring results, and overall health status. It is typically administered via subcutaneous injection, often 15 to 30 minutes before a meal.

What are the possible side effects of Huminsulin 30/70?

The most common side effect is low blood sugar (hypoglycemia), which can cause symptoms like headache, hunger, sweating, pale skin, irritability, dizziness, shakiness, or trouble concentrating. Other possible side effects include allergic reactions at the injection site (redness, swelling, itching), lipodystrophy (skin thickening or pits at the injection site), oedema (swelling), rashes, and weight gain.

Is Huminsulin 30/70 safe during pregnancy or breastfeeding?

Huminsulin 30/70 is generally considered safe to use during pregnancy if prescribed by a doctor, but it is essential to maintain good blood glucose control throughout pregnancy. Insulin needs may change during pregnancy and breastfeeding, so it's important to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can Huminsulin 30/70 be taken with other medications?

Huminsulin 30/70 can interact with various medications, which may either increase or decrease its blood glucose-lowering effect. It's crucial to inform your doctor about all current medications, including prescription, over-the-counter drugs, vitamins, and herbal supplements, to avoid potential interactions and allow for dose adjustments.

What precautions should be taken with Huminsulin 30/70?

Precautions include regularly monitoring your blood sugar levels, rotating injection sites to prevent skin changes, and avoiding alcohol consumption as it can increase the risk of hypoglycemia. Inform your doctor if you have kidney, liver, or heart problems, or low potassium levels. Do not share injection pens or syringes with others.

What happens if a dose is missed?

If you miss a dose of Huminsulin 30/70, administer the medicine after the meal. If a significant amount of time has passed since your meal, consult your doctor on whether to inject the missed dose. Do not administer extra medicine to make up for a missed dose. It is very important to follow your insulin regimen exactly.

How should Huminsulin 30/70 be stored?

Unopened cartridges and vials of Huminsulin 30/70 should be stored in a refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze the medicine, and do not use it if it has been frozen. Once opened or in use, cartridges can typically be stored at room temperature (below 30°C or 86°F) for up to 28 days, but always check the specific manufacturer's instructions for the exact duration. Protect it from direct sunlight and excessive heat.