Lupase 25000 Tablet (10 Tab)

LUPASE 25000 TABLET

LUPASE 25000 TABLET is a pancreatic enzyme supplement manufactured by Lupin Ltd.. It is prescribed to aid digestion in individuals whose pancreas does not produce enough digestive enzymes.

• Name:

  • Brand Name: LUPASE 25000 TABLET
  • Manufacturer: LUPIN LTD.

• Composition: LUPASE 25000 TABLET contains 300 mg of Pancreatin. Pancreatin is a blend of digestive enzymes, including:

  • Amylase (74700 USP Units)
  • Lipase (25000 USP Units)
  • Protease (62500 USP Units) These enzymes help break down carbohydrates, fats, and proteins in food.

• Uses: LUPASE 25000 TABLET is primarily used to manage pancreatic enzyme deficiency and related digestive issues. It is prescribed for conditions such as:

  • Exocrine Pancreatic Insufficiency (EPI) due to chronic pancreatitis or cystic fibrosis.
  • Replacement therapy after pancreatectomy surgery.
  • Assisting digestion and absorption of food in cases of maldigestion.
  • Pancreatic cancer and steatorrhea (loose fatty stool due to poor fat absorption).

• Dosage and Administration: LUPASE 25000 TABLET should be taken orally with meals or snacks. The tablet should be swallowed whole with water and not crushed, chewed, or broken, as this can cause mouth irritation and affect its efficacy. If swallowing is difficult, the contents can be sprinkled on a small amount of soft, non-acidic food like applesauce or yogurt and swallowed immediately without chewing. The dosage is determined by a healthcare professional based on the severity of the condition and individual response. It is important to drink plenty of fluids while taking this medicine.

• Side Effects: Common side effects may include:

  • Abdominal pain or discomfort
  • Diarrhea
  • Nausea and Vomiting
  • Constipation
  • Headache
  • Allergic reactions such as rash, itching, or swelling Patients with cystic fibrosis taking high doses may rarely develop a serious bowel condition called fibrosing colonopathy. Increased blood uric acid levels (hyperuricemia) leading to gout symptoms can also occur.

• Precautions:

  • Inform your doctor about any allergies, especially to animal-based products (this medicine is pork-based).
  • Caution is advised in patients with gout or hyperuricemia due to potential increases in uric acid levels.
  • Individuals with lactose intolerance should use this medicine carefully as it contains lactose.
  • Use with caution in cases of acute pancreatitis or acute exacerbation of chronic pancreatic disease.
  • Patients with kidney problems, asthma, or diabetes should consult their doctor, as the medicine may affect blood sugar levels.
  • LUPASE 25000 TABLET may reduce the absorption of folic acid and iron.
  • Avoid taking it at the same time as antacids.
  • Pregnant or breastfeeding women should consult their doctor before use.
  • Do not mix with hot food or liquids as heat can inactivate the enzymes.
  • The medicine may cause dizziness; therefore, caution is advised when driving or operating machinery.

• Storage: Store LUPASE 25000 TABLET in a cool, dry place, typically below 25°C or 30°C. Keep it away from direct heat, moisture, and sunlight, and out of the reach of children. Store in the original packaging.

What is Lupase 25000 Tablet used for?

Lupase 25000 Tablet is a pancreatic enzyme supplement used to treat exocrine pancreatic insufficiency (EPI). This condition occurs when the pancreas does not produce enough digestive enzymes to properly break down food. It is commonly associated with conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, or after surgical removal of the pancreas (pancreatectomy). The medication helps improve digestion, reduce stool frequency, alleviate stomach discomfort, and manage symptoms like bloating, gas, and diarrhea caused by poor digestion.

How does Lupase 25000 Tablet work?

Lupase 25000 Tablet contains Pancreatin, which is a combination of digestive enzymes: amylase, lipase, and protease. These enzymes are derived from an animal source (pork) and work by mixing thoroughly with food to help break down carbohydrates, fats, and proteins into smaller, more easily absorbable units as they pass through the gut.

What is the usual dosage for Lupase 25000 Tablet?

The dosage of Lupase 25000 Tablet is determined by a doctor based on the severity of pancreatic insufficiency and the patient's response to the medication. It should be taken during or immediately after a meal or snack with plenty of water. The tablets should be swallowed whole and not chewed, crushed, or held in the mouth to avoid irritation and ensure proper function. In some cases, the granules can be mixed with soft, acidic foods like yogurt, applesauce, or fruit juice if swallowing the tablet is difficult. It is important to increase fluid intake while taking this medicine.

What are the possible side effects of Lupase 25000 Tablet?

Common side effects may include nausea, mild stomach pain, abdominal discomfort or bloating, diarrhea, constipation, and a mild skin rash. Most of these side effects are temporary and usually resolve over time. More serious but rare side effects, especially in patients with cystic fibrosis receiving high doses, can include a bowel condition called fibrosing colonopathy (characterized by severe stomach pain, swelling, vomiting, and constipation) and an increase in blood uric acid levels (hyperuricemia), which can worsen gout.

Is Lupase 25000 Tablet safe during pregnancy or breastfeeding?

Lupase 25000 Tablet falls under pregnancy category C, meaning animal studies have shown harmful effects on the fetus, though human studies are limited. It may be unsafe to use during pregnancy, and a doctor will weigh the benefits against potential risks before prescribing it.

During breastfeeding, Lupase 25000 Tablet is probably safe to use, as limited human data suggests no significant risk to the baby. However, it is still recommended to consult a doctor before use.

Can Lupase 25000 Tablet be taken with other medications?

Lupase 25000 Tablet may interact with certain medications. It can reduce the absorption of iron salts and folic acid. It may also antagonize the hypoglycemic effect of acarbose and can affect blood sugar levels, requiring adjustments to diabetes treatment. Concurrent use with antacids should be avoided. It is crucial to inform your doctor about all medicines, including supplements and herbal products, you are currently taking.

What precautions should be taken?

Do not take Lupase 25000 Tablet if you are allergic to pork or any of its components, as the enzymes are animal-derived. Patients with cystic fibrosis should avoid high doses due to the risk of fibrosing colonopathy. Caution is advised for individuals with gout or high uric acid levels, as the medication can increase symptoms. Inform your doctor if you have asthma, heart problems, liver, or kidney problems. Maintain adequate hydration while taking this medicine. Avoid mixing the tablet with hot food or liquids, as heat can inactivate the enzymes.

What happens if a dose is missed?

If a dose of Lupase 25000 Tablet is missed, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one.

How should it be stored?

Lupase 25000 Tablet should be stored in a cool, dry place, ideally below 25°C or 30°C, away from direct sunlight, heat, and moisture. Keep it in its original packaging and out of the sight and reach of children.