Teniva M

TENIVA M

TENIVA M by Intas Pharmaceuticals Ltd. is a combination medication primarily used for the management of high blood sugar levels in adults with type 2 diabetes mellitus. It helps to control blood sugar when diet and exercise alone are insufficient, or when metformin alone does not provide adequate control.

• Name:
  • Brand Name: TENIVA M (often available as TENIVA-M Tablet ER or TENIVA M Tablet ER, indicating extended release).
• Composition:
  • TENIVA M contains two active ingredients: Metformin Hydrochloride (500 mg) and Teneligliptin (20 mg).
  • Metformin, a biguanide, works by reducing glucose production in the liver, decreasing glucose absorption in the intestines, and enhancing the body's sensitivity to insulin. Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases insulin synthesis and release from the pancreas in a glucose-dependent manner, while also decreasing hormones that raise blood sugar levels.
• Uses:
  • Treatment of Type 2 Diabetes Mellitus.
  • Helps prevent serious complications of diabetes such as kidney damage, blindness, nerve problems, and may reduce the risk of heart attack or stroke.
• Dosage and Administration:
  • TENIVA M is taken orally, typically after meals, as directed by a healthcare professional.
  • Tablets should be swallowed whole with a glass of water, without crushing, breaking, or chewing.
  • The dosage depends on the patient's condition, blood sugar levels, and other medications being taken. It should be taken regularly at the same time each day, and treatment should not be stopped without consulting a doctor.
• Side Effects:
  • Common: Nausea, vomiting, diarrhea, stomach upset, headache, nasal congestion, sore throat, upper respiratory tract infection, and hypoglycemia (low blood sugar level).
  • Serious: Lactic acidosis (a rare but serious condition) and Vitamin B12 deficiency (with long-term use).
• Precautions:
  • Contraindicated in patients with type 1 diabetes, diabetic ketoacidosis, severe kidney or liver impairment, severe heart problems, alcoholism, and severe systemic infections.
  • Avoid alcohol consumption as it can worsen blood sugar control and increase the risk of lactic acidosis.
  • Not recommended during pregnancy or breastfeeding; alternative treatments like insulin therapy should be considered.
  • Interactions may occur with certain medications such as carbonic anhydrase inhibitors, medicines that reduce metformin clearance (e.g., ranolazine, cimetidine), and beta-blockers.
• Storage:
  • Store below 25°C or at room temperature in a cool, dry place, away from direct sunlight and moisture.
  • Keep out of reach of children.

What is Teniva M used for?

Teniva M Tablet is primarily used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is typically prescribed when diet and exercise alone are not sufficient to control blood sugar. This medicine helps prevent serious complications of diabetes, such as kidney damage, blindness, nerve problems, and may also reduce the risk of heart attack or stroke.

How does Teniva M work?

Teniva M is a combination of two active ingredients: Teneligliptin and Metformin. Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the levels of incretin hormones. These hormones boost insulin synthesis and release from the pancreas, especially when glucose is present, and also reduce glucagon levels. Metformin, a biguanide, works by reducing the production of glucose in the liver, decreasing glucose absorption from the intestines, and enhancing the body's sensitivity to insulin, allowing cells to absorb and utilize more glucose.

What is the usual dosage of Teniva M?

The daily dose of Teniva M Tablet should be taken as prescribed by your doctor. It is typically recommended to take it once daily, preferably with a meal, to help reduce the chances of an upset stomach. Do not crush, chew, or break the tablet; swallow it whole with a glass of water. It is crucial to adhere to the prescribed dosage and not exceed it without consulting your doctor.

What are the possible side effects of Teniva M?

Common side effects of Teniva M include nausea, vomiting, diarrhea, stomach upset, headache, and low blood sugar (hypoglycemia). More serious, but rare, side effects can include lactic acidosis, a condition where there is a buildup of lactic acid in the blood. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling cold in arms and legs, difficulty in breathing, nausea, vomiting, or stomach pain. If you experience any severe or persistent side effects, you should consult your doctor immediately.

Is Teniva M safe during pregnancy or breastfeeding?

Teniva M Tablet is generally not recommended during pregnancy, as it may be unsafe and could harm the fetus. For pregnancy-related diabetes, insulin is often preferred over oral medications. It is also not advised to breastfeed during treatment with Teniva M, as the medicine may pass into breast milk and affect the nursing baby. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can Teniva M be taken with other medications?

Teniva M can interact with several medications. Taking it with other diabetes medicines like insulin or sulfonylureas can increase the risk of low blood sugar (hypoglycemia). Carbonic anhydrase inhibitors (e.g., acetazolamide) and certain medications that reduce metformin clearance (e.g., ranolazine, cimetidine) may increase the risk of lactic acidosis. Additionally, you may be advised to stop taking Teniva M before or at the time of receiving an injection of iodine-containing contrast media for X-rays or scans. Always inform your doctor about all medicines you are taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions.

What precautions should be taken?

Before taking Teniva M, inform your doctor if you have liver or severe kidney problems, heart disease, or a history of pancreatitis, as the medicine is contraindicated in these conditions due to an increased risk of serious side effects like lactic acidosis. Avoid consuming alcohol while on this medication, as it can lower blood sugar and increase the risk of lactic acidosis. It is also important to maintain a healthy diet and engage in regular exercise as part of your diabetes management plan. Your doctor may regularly monitor your kidney function and blood sugar levels during treatment.

What happens if a dose is missed?

If you miss a dose of Teniva M, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosage schedule. Do not take a double dose to make up for the missed one.

How should it be stored?

Teniva M Tablets should be stored below 25°C or 30°C in a cool, dry place. Keep the medicine away from direct sunlight, moisture, and heat. Always ensure the product is kept out of reach of children.