Olvance 20 Mg Tablet (10 Tab)

OLVANCE 20 MG TABLET (10 TAB) by SUN PHARMACEUTICAL IND.LTD.

Name

• Common Name: Olvance 20 mg Tablet
• Brand Name (US equivalent, if applicable): Benicar (US)

Composition

• Active Ingredients: Each tablet contains Olmesartan Medoxomil BP 20 mg. Olmesartan medoxomil is a selective angiotensin II receptor antagonist (AT1 subtype).

Uses

Olvance 20 mg Tablet is primarily used for the following conditions:

• Hypertension (High Blood Pressure): It effectively lowers high blood pressure by relaxing blood vessels, improving circulation, and reducing strain on the heart.
• Prevention of Heart Attack and Stroke: By controlling blood pressure, it helps reduce the risk of future cardiovascular events.
• Kidney Protection: It is also effective in preserving kidney function, particularly in patients with diabetes.

Dosage and Administration

• Adults: The usual recommended starting dose is 10 mg once daily. This may be increased to 20 mg once daily if blood pressure is not adequately controlled. For further reduction after 2 weeks, the dose may be increased to 40 mg once daily. Doses above 40 mg typically do not provide greater effect.
• Administration: Olvance 20 mg Tablet can be taken with or without food. It is important to take the medicine at approximately the same time each day to maintain consistent blood pressure control. The first dose may be suggested before bedtime due to potential dizziness.
• Special Populations: No initial dosage adjustment is generally recommended for elderly patients or those with moderate renal or hepatic impairment, though caution is advised.

Side Effects

Common Side Effects:

• Dizziness, Headache
• Nausea, Diarrhea, Stomach pain, Indigestion
• Flu-like symptoms, Tiredness
• Back pain, Bronchitis, Creatine phosphokinase increased
• Hematuria (blood in urine), Hyperglycemia, Hypertriglyceridemia
• Pharyngitis, Rhinitis, Sinusitis, Cough, Runny or stuffy nose, Sore throat
• Muscle pain, Joint inflammation, Swelling

Serious Side Effects (Rare):

• Allergic reactions (e.g., swelling of the face, mouth, and/or larynx).
• Significant reduction in blood pressure leading to severe light-headedness or fainting.

Precautions

• Pregnancy: Olvance 20 mg Tablet is contraindicated in the second and third trimesters of pregnancy and not recommended in early pregnancy due to potential harm to the fetus.
• Breastfeeding: Not recommended for use in breastfeeding women.
• Renal/Hepatic Impairment: Use with caution. Changes in renal function may occur, especially in susceptible individuals. The dose should not exceed 20 mg daily in moderate hepatic impairment. Maximum 20 mg daily if eGFR 20–60 mL/minute/1.73 m2 and avoided if eGFR is less than 20 mL/minute/1.73 m2.
• Drug Interactions:
  • Avoid potassium supplements and salt substitutes unless advised by a doctor, as it can increase blood potassium levels.
  • Caution is advised with alcohol consumption, as it may increase the risk of low blood pressure.
  • Avoid concomitant use with anti-inflammatory medicines like ibuprofen without consulting a doctor, as this may increase the risk of kidney problems.
  • Co-administration with ACE inhibitors or aliskiren is generally not recommended.
• Monitoring: Regular monitoring of kidney function, blood pressure, and electrolyte levels (e.g., potassium) is recommended.
• Driving/Operating Machinery: May cause dizziness; exercise caution.
• Children: Safety and effectiveness in pediatric patients have not been established; not recommended for children below 6 years.

Storage

• Store in a cool and dry place, protected from moisture and heat.
• Keep out of the reach and sight of children.
• Typically stored at room temperature, below 30°C.

OLVANCE 20 MG TABLET contains Olmesartan Medoxomil, which is an angiotensin II receptor blocker (ARB) used to treat high blood pressure.

What is OLVANCE 20 MG TABLET used for?

OLVANCE 20 MG TABLET is primarily used to treat hypertension (high blood pressure). It helps to lower blood pressure, which in turn reduces the risk of serious complications such as heart attacks, strokes, and kidney problems, particularly in patients with diabetes. It may be used alone or in combination with other antihypertensive agents.

How does OLVANCE 20 MG TABLET work?

OLVANCE 20 MG TABLET contains Olmesartan Medoxomil, which is an angiotensin II receptor blocker (ARB). It works by blocking the action of angiotensin II, a hormone in the body that causes blood vessels to narrow. By blocking this hormone, it relaxes and widens the blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently. This process lowers blood pressure.

What is the usual dosage of OLVANCE 20 MG TABLET?

The dosage of OLVANCE 20 MG TABLET must be individualized by a doctor. For adults, the usual recommended starting dose is 20 mg once daily. If further blood pressure reduction is needed after two weeks of therapy, the dose may be increased to 40 mg once daily. Doses above 40 mg do not typically provide a greater effect. It can be taken with or without food.

What are the possible side effects of OLVANCE 20 MG TABLET?

Common side effects may include dizziness, headache, nausea, indigestion, diarrhea, flu-like symptoms, back pain, and upper respiratory tract infections. Less common side effects can include chest pain and peripheral edema. Most of these side effects are temporary and resolve as your body adjusts to the medicine. However, if any side effects persist or worsen, it's important to consult your doctor.

Is OLVANCE 20 MG TABLET safe during pregnancy or breastfeeding?

OLVANCE 20 MG TABLET is generally considered unsafe during pregnancy. It is not recommended in early pregnancy and must not be taken after the third month of pregnancy, as it can cause serious injury or even death to the developing fetus. It is classified as Pregnancy Categories C (first trimester) and D (second and third trimesters). For breastfeeding mothers, it is not known whether Olmesartan is excreted in human milk, but due to the potential for adverse effects on the nursing infant, it is not recommended during breastfeeding. A doctor will weigh the importance of the drug to the mother versus the potential risk to the infant.

Can OLVANCE 20 MG TABLET be taken with other medications?

Caution is advised when taking OLVANCE 20 MG TABLET with certain other medications:

• Aliskiren or ACE inhibitors (e.g., enalapril, lisinopril, ramipril): Co-administration may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels.
• Potassium supplements and potassium-sparing diuretics (e.g., amiloride, spironolactone): These can increase potassium levels in the blood.
• Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., aspirin, ibuprofen): May lead to kidney failure when taken together with OLVANCE 20 MG TABLET and can also increase potassium levels.
• Lithium: Concomitant use can increase the risk of lithium toxicity.
• Diuretics: May increase the risk of low blood pressure and kidney dysfunction.

Always inform your doctor about all other medications, including herbal and vitamin supplements, you are taking to avoid potential interactions.

What precautions should be taken when using OLVANCE 20 MG TABLET?

• Kidney or Liver Problems: Use with caution in patients with kidney or liver disease. Your doctor may monitor kidney function, blood pressure, and potassium levels regularly. Dosage adjustments may be needed.
• Dehydration/Volume Depletion: Patients who are dehydrated or on high doses of diuretics may be more susceptible to low blood pressure, and a lower starting dose might be considered under medical supervision.
• Alcohol: Avoid consuming alcohol as it can increase the risk of low blood pressure and cause adverse effects like dizziness.
• Driving/Operating Machinery: OLVANCE 20 MG TABLET may cause dizziness or tiredness, so caution should be exercised when driving or operating machinery.
• Potassium-rich foods: Avoid potassium supplements and foods rich in potassium (e.g., bananas, fruit juice, coconut water, broccoli) unless advised by your doctor, as this medicine can increase blood potassium levels.
• Sudden discontinuation: Do not stop taking the medicine suddenly without consulting your doctor, as this can cause blood pressure to spike.

What happens if a dose of OLVANCE 20 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should OLVANCE 20 MG TABLET be stored?

Store OLVANCE 20 MG TABLET in a cool and dry place below 30°C, protected from light and moisture. Keep it out of the sight and reach of children and pets.