Primodil At Tablet (10 Tab)

PRIMODIL AT TABLET (10 TAB) by MEDLEY PHARMACEUTICALS LTD.

PRIMODIL AT TABLET is a combination medication prescribed for the management of cardiovascular conditions, primarily high blood pressure.

Name

• Brand Name: PRIMODIL AT TABLET
• Manufacturer: MEDLEY PHARMACEUTICALS LTD.

Composition

Each tablet of PRIMODIL AT contains two active ingredients:

• Amlodipine (5mg)
• Atenolol (50mg)

Amlodipine is a calcium channel blocker that works by relaxing and widening constricted blood vessels, improving blood flow, and reducing the heart's workload. Atenolol is a beta-blocker that slows down the heart rate and decreases the force of heart contractions, thereby lowering blood pressure and the heart's oxygen demand.

Uses

PRIMODIL AT TABLET is primarily used for:

• Managing high blood pressure (hypertension).
• Treating and preventing angina (heart-related chest pain).
• Reducing the risk of future heart attacks and strokes in patients with cardiovascular risk.
• Managing certain heart-related conditions like irregular heartbeats and symptoms of heart failure.

Dosage and Administration

• PRIMODIL AT TABLET should be taken once daily.
• It can be taken with or without food.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Adhere strictly to the dosage instructions provided by your doctor. Do not stop taking the medication abruptly without consulting your doctor, as this can worsen your condition.
• If a dose is missed, take it as soon as you remember, unless it's almost time for the next dose. Do not double the dose.

Side Effects

Common Side Effects:

• Dizziness, light-headedness, headache, sleepiness, tiredness.
• Nausea, indigestion, constipation, diarrhea, stomach pain.
• Ankle swelling (edema) or swelling of other body parts.
• Palpitations (fast heartbeat) or slow heart rate.
• Cold extremities, flushing (sense of warmth).
• Muscle cramps/pain, increased sweating, increased urination at night, changes in taste.

Serious Side Effects (seek immediate medical attention if experienced):

• Chest pain or shortness of breath (possible signs of a heart attack).
• Inflammation of the pancreas, causing severe stomach pain that radiates to the back.

Precautions

• Allergies: Do not take if you are allergic to Amlodipine, Atenolol, or any other ingredients in the tablet.
• Heart Conditions: Not recommended for patients with severe heart problems such as heart block, severe heart failure, aortic stenosis (narrowing of arteries), or cardiogenic shock. Use with caution if you have a history of a recent heart attack or heart failure.
• Blood Pressure: Avoid if you have severe hypotension (very low blood pressure).
• Kidney/Liver Disease: Use with caution in patients with kidney or liver conditions, as dosage adjustments may be necessary.
• Pregnancy and Breastfeeding: PRIMODIL AT is generally not recommended during pregnancy (Atenolol is pregnancy category D) and is probably unsafe during breastfeeding. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Alcohol: Avoid alcohol consumption while taking this medicine, as it can intensify side effects like dizziness or drowsiness and lead to extremely low blood pressure.
• Driving/Operating Machinery: May cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how the medicine affects you.
• Drug Interactions: Inform your doctor about all other medicines, including over-the-counter drugs, herbal supplements, and vitamins, to prevent potential interactions. Notable interactions include other antihypertensives, NSAIDs, cardiac glycosides, and CYP3A4 inhibitors.
• Diabetes: Use with caution in diabetic patients as it may mask symptoms of low blood sugar.
• Surgery: Inform your doctor if you are undergoing major surgery, as treatment may need to be stopped temporarily.

Storage

• Store PRIMODIL AT TABLET in a cool and dry place, protected from direct sunlight, moisture, and heat.
• Keep the medicine out of sight and reach of children and pets.
• Store below 30°C.
• Do not use expired medicines.

What is Primodil AT Tablet used for?

Primodil AT Tablet is a combination medication primarily used to treat hypertension (high blood pressure) and angina pectoris (chest pain caused by a lack of oxygen supply to the heart). It also helps in preventing severe cardiovascular events like heart attacks and strokes in patients with cardiovascular risk.

How does Primodil AT Tablet work?

Primodil AT Tablet contains two active ingredients: Amlodipine and Atenolol. Amlodipine is a calcium channel blocker that works by relaxing and widening blood vessels, which improves blood flow and reduces blood pressure. Atenolol is a beta-blocker that decreases heart rate and the force of heart contractions, thereby reducing the heart's workload and lowering blood pressure. The combined action of these two medicines effectively controls blood pressure and reduces strain on the heart.

What is the usual dosage of Primodil AT Tablet?

Primodil AT Tablet is typically taken once daily, with or without food, as advised by your doctor. The tablet should be swallowed whole with a glass of water and not crushed or chewed. Your doctor will determine the correct dose and duration based on your age, body weight, and medical condition. It is crucial not to stop taking the medication suddenly without consulting your doctor, as this can lead to a sudden increase in blood pressure.

What are the possible side effects of Primodil AT Tablet?

Common side effects of Primodil AT Tablet may include dizziness, light-headedness, fatigue, nausea, diarrhea, constipation, headache, sleepiness, ankle swelling (peripheral edema), a slow heart rate, palpitations, and cold hands and feet. Most side effects are usually mild and temporary. If any side effects persist or worsen, it is advisable to consult your doctor.

Is Primodil AT Tablet safe during pregnancy or breastfeeding?

Primodil AT Tablet is generally not recommended during pregnancy, as there is evidence of risk to the developing baby. Atenolol, one of the active ingredients, is considered a pregnancy category D drug. It is also advised against breastfeeding during treatment with this medicine as it may pass into breast milk and harm the infant. Always consult your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

Can Primodil AT Tablet be taken with other medications?

Primodil AT Tablet can interact with certain other medications. It is important to inform your doctor about all medicines you are taking, including prescribed, non-prescribed, herbal medicines, and dietary supplements. Some medications that may interact include other blood pressure-lowering medicines (e.g., nifedipine, verapamil), NSAIDs like ibuprofen, cardiac glycosides like digoxin, certain antibiotics (e.g., erythromycin, clarithromycin), and medicines used to manage fungal infections (e.g., ketoconazole, itraconazole). Additionally, grapefruit juice should be avoided as it can increase amlodipine levels and potentially lead to extremely low blood pressure.

What precautions should be taken while using Primodil AT Tablet?

Before taking Primodil AT Tablet, inform your doctor if you have any liver or kidney problems, severe high or low blood pressure, asthma, diabetes, or other severe heart conditions like heart failure or aortic stenosis. Alcohol consumption should be avoided as it can intensify side effects like dizziness and drowsiness. The medication may cause dizziness and sleepiness, so caution is advised when driving or operating machinery.

What happens if a dose of Primodil AT Tablet is missed?

If you miss a dose of Primodil AT Tablet, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one.

How should Primodil AT Tablet be stored?

Primodil AT Tablet should be stored in a cool, dry place, protected from direct sunlight, moisture, and heat. Keep it out of the reach of children and pets. Always check the expiration date on the package before use and properly discard any unused medicine.