Trivogo 1

TRIVOGO 1 by ALEMBIC PHARMACEUTICALS LTD

Name

• Brand Name: TRIVOGO 1
• Common Name: Glimepiride, Metformin, and Voglibose combination tablet.

Composition TRIVOGO 1 is a combination of three antidiabetic medicines:

• Glimepiride (1 mg)
• Metformin Hydrochloride (500 mg)
• Voglibose (0.2 mg)

Uses TRIVOGO 1 is prescribed for the management of Type 2 Diabetes Mellitus in adults. It is used when diet, exercise, and single-agent or dual therapy are insufficient to adequately control blood sugar levels. This medication helps to:

• Control high blood glucose levels.
• Slow down the breakdown of food in the intestine into simple glucose, thereby decreasing the rise in blood glucose levels after meals.
• Facilitate the elimination of excess glucose from the body through urine.
• Reduce the risk of long-term diabetes-related complications such as kidney damage, eye damage, nerve problems, and loss of limbs, as well as reduce the chance of heart attack or stroke.

Dosage and Administration TRIVOGO 1 should be taken orally as directed by a physician. The typical dosage is usually once or twice daily with or immediately before meals.

• Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• Take it regularly at the same time each day to maximize benefits and maintain consistent drug levels.
• The dosage may vary based on individual condition, severity of the ailment, and response to treatment.
• Do not alter the dosage or discontinue the medication without consulting a healthcare provider.
• If a dose is missed, take it as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose.

Side Effects Common Side Effects:

• Hypoglycemia (low blood sugar level), with symptoms such as sweating, dizziness, headache, and shaking.
• Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, and altered taste.
• Flatulence, stomach discomfort, and bloating.
• Headache.
• Skin rash and itching.
• Respiratory tract infection.
• Edema (swelling) and blurred vision.
• Weight gain.

Serious Side Effects (Rare):

• Lactic acidosis.
• Liver problems (e.g., jaundice or hepatitis).
• Pancreatitis.
• Severe skin reactions.

Precautions

• Contraindications: TRIVOGO 1 is not recommended for individuals with Type 1 Diabetes Mellitus, diabetic ketoacidosis, severe kidney or liver disease, acute conditions (dehydration, severe infection, severe trauma), severe ketosis, lung or heart problems, or known allergy to any of its components or other sulfonylureas/sulphonamides.
• Pregnancy and Breastfeeding: Not recommended for pregnant or breastfeeding women as it may cause harm to the fetus or nursing child.
• Alcohol Consumption: Avoid alcohol as it can increase the risk of hypoglycemia and lactic acidosis.
• Drug Interactions: Inform your doctor about all medicines, including over-the-counter drugs, herbal supplements, and dietary supplements. Interactions can occur with antibacterials, antifungals, other oral antidiabetics, insulin, anticancer drugs, disopyramide, fenyramidol, pentoxifylline, medicines for joint pain, corticosteroids, diuretics, laxatives, phenytoin, fenfluramine, and dolutegravir.
• Lifestyle: Adherence to a balanced diet and regular exercise is crucial for optimal outcomes.
• Monitoring: Regular monitoring of blood sugar levels, blood cell counts, and liver function is advised.
• Hypoglycemia Risk: Carry a fast-acting source of glucose (e.g., sugary food or fruit juice) for immediate relief from low blood sugar symptoms.

Storage Store TRIVOGO 1 below 25°C or 30°C in a cool, dry place. Keep it away from moisture and direct sunlight. Keep out of the reach of children and pets.

TRIVOGO 1 by Alembic Pharmaceuticals Ltd. is a combination medication primarily used for the management of Type 2 Diabetes Mellitus. It contains three active ingredients: Glimepiride, Metformin, and Voglibose, which work together to help control high blood sugar levels.

Here are some frequently asked questions about TRIVOGO 1:

What is TRIVOGO 1 used for?

TRIVOGO 1 is prescribed to adults with Type 2 Diabetes Mellitus when diet, exercise, and single-agent or dual therapy with other anti-diabetic medicines are not sufficient to adequately control blood sugar levels. It helps to regulate glucose metabolism and maintain optimal sugar levels, reducing the risk of diabetes-related complications such as kidney damage, eye problems, nerve issues, and cardiovascular disease.

How does TRIVOGO 1 work?

TRIVOGO 1 combines three anti-diabetic medicines, each with a distinct mechanism of action:

• Glimepiride: A sulfonylurea that stimulates the beta cells of the pancreas to release more insulin, which helps lower blood glucose.
• Metformin: A biguanide that primarily reduces glucose production in the liver, delays glucose absorption from the intestines, and improves the body's sensitivity to insulin in peripheral tissues.
• Voglibose: An alpha-glucosidase inhibitor that delays the breakdown and absorption of carbohydrates from the small intestine, thereby preventing a rapid increase in blood glucose levels after meals. The synergistic action of these components provides comprehensive blood sugar control.

What is the usual dosage of TRIVOGO 1?

TRIVOGO 1 should be taken orally as directed by your doctor. It is typically recommended to be taken once daily with or immediately after a meal to minimize gastrointestinal discomfort and optimize effectiveness. The tablet should be swallowed whole with a glass of water and not crushed or chewed. Your doctor will determine the appropriate dose based on your individual condition and blood sugar levels.

What are the possible side effects of TRIVOGO 1?

Common side effects of TRIVOGO 1 can include low blood glucose levels (hypoglycemia), nausea, vomiting, diarrhea, abdominal pain, loss of appetite, altered taste, headache, and upper respiratory tract infection. Some individuals may also experience dizziness, blurred vision, or weight gain. Rarely, more serious side effects like lactic acidosis can occur, especially in patients with severe kidney or liver disease.

Is TRIVOGO 1 safe during pregnancy or breastfeeding?

TRIVOGO 1 is generally not recommended for use during pregnancy as it may be unsafe and could harm the developing baby. It is also considered probably unsafe during breastfeeding as the drug may pass into breast milk and potentially harm the infant. It is crucial to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can TRIVOGO 1 be taken with other medications?

TRIVOGO 1 can interact with various other medications. Inform your doctor about all prescribed and non-prescribed medicines, herbal supplements, and dietary supplements you are taking. Particular caution is needed with other anti-diabetic medications, oral contraceptives, water pills (diuretics), rifampicin, phenytoin, thyroid medications, and blood thinners like phenprocoumon. Alcohol consumption should be avoided due to an increased risk of hypoglycemia and lactic acidosis.

What precautions should be taken with TRIVOGO 1?

• Hypoglycemia: Be aware of the signs of low blood sugar (sweating, dizziness, headache, shaking) and carry a fast-acting source of glucose for immediate relief.
• Kidney and Liver Disease: TRIVOGO 1 is generally not recommended for patients with severe kidney or liver disease.
• Alcohol: Avoid consuming alcohol, as it can increase the risk of low blood sugar and lactic acidosis.
• Diet and Exercise: This medication works best when used in conjunction with a proper diet and regular exercise regimen.
• Monitoring: Regular monitoring of blood sugar levels is essential, and your doctor may recommend periodic blood tests to monitor liver function and blood cell counts.
• Surgery/Medical Procedures: Inform your doctor if you have an upcoming surgery or medical procedure, especially those involving contrast media, as the medication may need to be stopped a few days prior.
• Sun Sensitivity: TRIVOGO 1 may increase skin sensitivity to the sun, so using sunscreen is advisable.

What happens if a dose of TRIVOGO 1 is missed?

If you miss a dose of TRIVOGO 1, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can be harmful and lead to a significant drop in blood glucose levels.

How should TRIVOGO 1 be stored?

Store TRIVOGO 1 tablets below 25°C or 30°C in a cool, dry place. Keep the medicine away from heat, moisture, and direct sunlight. It should always be kept out of the reach of children and pets.