Difizma Cap

DIFIZMA CAPSULE

DIFIZMA CAPSULE by LUPIN LTD is a combination medication designed for the maintenance treatment of uncontrolled asthma in adults.

• Name:

  • Brand Name: DIFIZMA CAPSULE
  • Manufacturer: Lupin Ltd.

• Composition: Each capsule contains a synergistic blend of active ingredients:

  • Glycopyrronium Bromide (63 mcg)
  • Indacaterol (173 mcg)
  • Mometasone Furoate (160 mcg)

• Uses: DIFIZMA CAPSULE is prescribed as a maintenance treatment for adult patients with uncontrolled asthma. It works by reducing inflammation in the airways, relaxing airway muscles, improving lung function, and consequently reducing symptoms like wheezing, coughing, and breathlessness. It also helps in decreasing the frequency of asthma attacks. This medicine is not intended for the relief of sudden shortness of breath or acute asthma attacks; a rescue inhaler should be used in such cases.

• Dosage and Administration: The typical dosage is one capsule daily. It should be taken at a consistent time each day to maintain stable blood levels of the medication. DIFIZMA CAPSULE can be administered with or without food; however, taking it with food may help mitigate gastrointestinal discomfort. Proper inhaler technique is crucial for optimal effectiveness. After using the inhaler, rinsing the mouth or gargling with water is recommended to reduce the risk of oral thrush. Do not exceed the prescribed dosage.

• Side Effects:

  • Common Side Effects: Nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, fatigue, skin rash, itching, nasopharyngitis (inflammation of the nasal passages and throat), upper respiratory tract infection, and exacerbation of asthma.
  • Serious Side Effects: Allergic reactions (including rash, hives, swelling, difficulty breathing), liver problems, kidney problems, changes in blood counts, muscle pain or weakness, nerve damage, mood changes, and fast heart rate or palpitations. Consult your doctor if any persistent or severe side effects occur.

• Precautions:

  • Inform your doctor about any pre-existing medical conditions, particularly kidney or liver problems, cardiovascular disorders (such as arrhythmias), or diabetes.
  • DIFIZMA CAPSULE is contraindicated for individuals with known allergies to glycopyrrolate, indacaterol, mometasone, or any other components of the medicine.
  • Caution is advised for pregnant or breastfeeding women, and consultation with a healthcare professional is recommended.
  • Patients should avoid smoking as it can worsen their respiratory condition.
  • Diabetic patients should monitor their blood glucose levels as advised by their doctor, as the mometasone component may affect blood sugar control.
  • It may interact with strong CYP3A4 inhibitors (e.g., ketoconazole) and beta-blockers (e.g., propranolol).
  • Do not discontinue the medication abruptly, even if symptoms improve, without consulting your doctor.

• Storage: Store DIFIZMA CAPSULE in a cool, dry place, protected from direct sunlight and moisture. Keep the medication out of reach of children and pets.

What is DIFIZMA CAP used for?

DIFIZMA CAP is primarily used for the maintenance treatment of inadequately controlled asthma in adults. It helps manage asthma symptoms by improving lung function and reducing exacerbations (worsening of symptoms).

How does DIFIZMA CAP work?

DIFIZMA CAP is a combination of three active ingredients: Glycopyrronium, Indacaterol, and Mometasone.

• Glycopyrronium is a long-acting muscarinic antagonist (LAMA) that helps widen the airways by blocking certain receptors and reducing secretions.
• Indacaterol is an ultra long-acting beta2-adrenergic agonist (ultraLABA) that relaxes and opens the air passages in the lungs.
• Mometasone is an inhaled corticosteroid (ICS) with strong anti-inflammatory effects, which reduces swelling in the airways and helps control symptoms like wheezing and coughing.

What is the usual dosage for DIFIZMA CAP?

The typical dosage is the content of one DIFIZMA CAP capsule, inhaled once daily using the provided inhaler (Lupihaler). It's important not to exceed the recommended dose and to administer the medicine at the same time each day for consistent effects.

What are the possible side effects of DIFIZMA CAP?

Common side effects can include exacerbation of asthma symptoms, nasopharyngitis (inflammation of the throat and nasal passages), upper respiratory tract infections, and headaches. Other reported side effects may include influenza, back pain, urinary tract infection, pharyngitis, pyrexia (fever), stomach pain, vomiting, and rash. Rinsing your mouth and throat with water or brushing your teeth after using the inhaler can help minimize some of these side effects, such as oral thrush.

Is DIFIZMA CAP safe during pregnancy or breastfeeding?

Information regarding the use of DIFIZMA CAP during pregnancy and breastfeeding is limited or not available. It is crucial to consult your doctor if you are pregnant, planning a pregnancy, or currently breastfeeding to discuss the potential risks and benefits and ensure the safety of both you and your baby.

Can DIFIZMA CAP be taken with other medications?

DIFIZMA CAP can interact with other medicines. It is important to inform your doctor about all prescription and non-prescription medications, vitamins, and herbal supplements you are currently taking. For example, strong CYP3A4 inhibitors (like ketoconazole) may increase the effects of mometasone and indacaterol, while beta-blockers (like propranolol) can decrease the effectiveness of DIFIZMA CAP and may cause severe breathing difficulties.

What precautions should be taken while using DIFIZMA CAP?

• DIFIZMA CAP is for maintenance treatment and should not be used for sudden shortness of breath or acute asthma attacks; a rescue inhaler should be used in such cases.
• Ensure proper inhaler technique for the medicine to work effectively.
• Do not stop taking the medicine abruptly, even if you feel better, as this can worsen your symptoms.
• Inform your doctor about any existing kidney or liver conditions, though DIFIZMA CAP is generally considered safe for patients with these conditions without dose adjustment.
• Avoid smoking, as it can irritate the lungs and worsen asthma.
• If you have cardiovascular disorders, discuss this with your doctor, as indacaterol can affect heart rate and blood pressure.
• Patients with hyperglycemia or diabetes should be cautious, as the mometasone component may potentially affect blood sugar control.

What happens if a dose of DIFIZMA CAP is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should DIFIZMA CAP be stored?

DIFIZMA CAP should be stored in a cool and dry place, away from direct sunlight. The recommended storage temperature is typically below 30°C. Keep the medicine out of the sight and reach of children.