Pentanerv M 100 (10 Tab)

PENTANERV M 100 (10 TAB)

PENTANERV M 100 is a combination medication manufactured by Alkem Laboratories Ltd..

Composition PENTANERV M 100 contains two active ingredients: Gabapentin (100mg) and Methylcobalamin (Mecobalamin or Vitamin B12) (500mcg). Gabapentin is an anticonvulsant that works by binding to specific sites on voltage-gated calcium channels, which helps relieve nerve pain and lowers the risk of seizures. Methylcobalamin is a coenzyme form of vitamin B12 that rejuvenates and protects damaged nerve cells by producing myelin, a substance that forms a protective covering around nerve fibers.

Uses PENTANERV M 100 is primarily used to treat neuropathic pain (nerve pain) and epilepsy (seizures). It is effective in managing chronic pain caused by nerve damage due to conditions such as diabetes (diabetic neuropathy), shingles/herpes zoster infection (post-herpetic neuralgia), or spinal cord injury. It also helps control partial seizures by stabilizing electrical activity in the brain.

Dosage and Administration PENTANERV M 100 should be taken orally as advised by a physician. It can be taken with or without food, preferably at bedtime, to maintain a consistent level of the medicine in the body. The dosage and duration of treatment are determined by the doctor based on the individual's medical condition and response. It is crucial not to exceed the recommended dose and to avoid stopping the medication abruptly, as this can lead to withdrawal symptoms or worsen the underlying condition.

Side Effects Common side effects may include dizziness, sleepiness, tiredness, nausea, vomiting, confusion, headache, and lack of coordination. Serious side effects, though less common, can include severe depressive symptoms along with self-harming thoughts. If any side effects persist or worsen, medical attention should be sought.

Precautions

• Pregnancy and Breastfeeding: Consult a doctor before taking PENTANERV M 100 if pregnant, planning pregnancy, or breastfeeding, as it may interfere with fetal development or be excreted into breast milk.
• Alcohol Consumption: Avoid consuming alcohol, as it can increase dizziness and sleepiness.
• Driving and Operating Machinery: Due to potential dizziness, drowsiness, or impaired cognitive function, avoid driving or operating machinery until you know how the medicine affects you.
• Medical Conditions: Inform the doctor about any history of heart problems, bipolar syndrome, nervous system disorders, kidney diseases, liver impairment, or a history of drug abuse.
• Drug Interactions: Inform your doctor about all prescription, non-prescription drugs, and herbal products being used. Specific interactions include antacids (take with a two-hour gap), certain antibiotics like tetracycline, and medicines for depression or anxiety. Morphine may require a lower dose of PENTANERV M 100.
• Withdrawal Symptoms: Do not stop taking the medicine suddenly without consulting a doctor, as it can cause withdrawal symptoms like anxiety, nausea, pain, and sweating.

Storage PENTANERV M 100 should be stored in a cool and dry place, away from direct sunlight, at room temperature (10ºC to 25ºC or below 30ºC). Keep it out of sight and reach of children.

Here are the most frequently asked questions about PENTANERV M 100, a medicine manufactured by ALKEM LABORATORIES LTD, which contains Gabapentin and Methylcobalamin.

What is PENTANERV M 100 used for?

PENTANERV M 100 is primarily used to treat neuropathic pain, which is nerve pain caused by nerve damage. This can include conditions such as diabetic neuropathy, post-herpetic neuralgia (pain after shingles), and pain from spinal cord injuries. It is also used to manage epilepsy (seizures).

How does PENTANERV M 100 work?

PENTANERV M 100 is a combination of two active ingredients: Gabapentin and Methylcobalamin (a form of Vitamin B12). Gabapentin, an anticonvulsant, works by stabilizing electrical activity in the brain and modulating calcium channel activity in nerve cells, which helps to reduce the release of neurotransmitters involved in pain signaling and lowers the risk of seizures. Methylcobalamin supports nerve health by aiding in the production of myelin, a substance that protects nerve fibers, and helps in the regeneration and repair of damaged nerve cells. Together, they relieve nerve pain and support overall nerve function.

What is the usual dosage of PENTANERV M 100?

The dosage of PENTANERV M 100 is determined by a healthcare provider based on the patient's medical condition, age, and response to treatment. It is typically administered orally, usually 1 to 3 times daily, and can be taken with or without food. It's often recommended to take it around the same time each day, and sometimes preferably before bedtime to manage symptoms and reduce daytime drowsiness. Treatment usually begins with a small dose and is gradually increased. Do not exceed the prescribed dose or stop the medication abruptly.

What are the possible side effects of PENTANERV M 100?

Common side effects of PENTANERV M 100 may include dizziness, drowsiness, tiredness, nausea, vomiting, uncoordinated body movements, headache, dry mouth, blurred vision, and swelling of hands or feet. These side effects are usually mild and temporary. More serious but rare side effects can include severe allergic reactions (rash, itching, swelling, trouble breathing), mood changes (depression, anxiety, suicidal thoughts), unusual eye movements, muscle weakness, or severe dizziness. If any side effects persist or worsen, or if serious side effects occur, medical attention should be sought immediately.

Is PENTANERV M 100 safe during pregnancy or breastfeeding?

PENTANERV M 100 is generally not recommended during pregnancy unless clearly prescribed by a doctor, as its safety is not well-established and it might affect fetal development. Gabapentin, one of the components, is excreted into breast milk. Therefore, pregnant and breastfeeding women should consult their doctor before taking this medication, and caution is advised if breastfeeding.

Can PENTANERV M 100 be taken with other medications?

PENTANERV M 100 can interact with certain other medications. It should not be taken at the same time as antacids containing aluminum or magnesium, as they can reduce gabapentin absorption; a gap of at least two hours is recommended. Co-administration with opioids (like morphine) or sedatives can increase drowsiness and dizziness. It may also interact with some antidepressants, antibiotics (like tetracycline), and certain other anti-convulsants. Always inform your doctor about all prescription, non-prescription drugs, and herbal products you are taking to prevent dangerous drug interactions.

What precautions should be taken with PENTANERV M 100?

Avoid consuming alcohol while taking PENTANERV M 100 as it can increase drowsiness and dizziness. Due to potential dizziness and sleepiness, avoid driving or operating heavy machinery until you know how the medication affects you. Patients with kidney problems may need dosage adjustments as the body removes gabapentin through the kidneys. Do not stop the medication suddenly without consulting your doctor, as abrupt discontinuation can lead to withdrawal symptoms like anxiety, insomnia, nausea, or even seizures. Report any unusual mood changes, depression, or suicidal thoughts to your doctor immediately.

How should PENTANERV M 100 be stored?

Store PENTANERV M 100 in its original container, tightly closed, and away from direct sunlight. It should be stored at room temperature, not exceeding 25°C. Keep it out of reach of children and pets. Dispose of any unused medicine properly.