Dompan Sr Tablet (10 Tab)

DOMPAN SR TABLET by MEDLEY PHARMACEUTICALS LTD.

Name

Brand Name: DOMPAN SR TABLET Common Name: Pantoprazole and Domperidone Sustained Release Tablet

Composition

Each DOMPAN SR Tablet contains two active ingredients:

• Pantoprazole: 40 mg (a proton pump inhibitor)
• Domperidone (Sustained Release): 30 mg (a prokinetic and anti-nausea agent)

Uses

DOMPAN SR Tablet is a prescription medication used to treat various conditions related to the stomach and digestive system. It is primarily prescribed for:

• Gastroesophageal Reflux Disease (GERD) or Acid reflux, especially when not adequately controlled by pantoprazole alone
• Heartburn
• Dyspepsia (indigestion)
• Gastritis
• Peptic ulcers (gastric and duodenal ulcers)
• Nausea and vomiting
• Upper abdominal discomfort, bloating, and regurgitation of gastric contents
• Erosive esophagitis (inflammation of the esophagus due to acid reflux)

Dosage and Administration

• DOMPAN SR Tablet should be taken as directed by a healthcare professional.
• It is typically administered once daily, preferably in the morning, before a meal.
• For optimal absorption and effectiveness, it should be taken on an empty stomach, approximately 30-60 minutes before food.
• Swallow the tablet whole with a glass of water; do not crush, chew, open, or break it.
• The dosage and duration of treatment depend on the patient's condition and response to therapy.
• Consistent use is important, and treatment should not be stopped abruptly to prevent symptom recurrence.

Side Effects

Common side effects associated with DOMPAN SR Tablet include:

• Diarrhea
• Stomach pain
• Flatulence (gas)
• Dry mouth
• Headache
• Dizziness
• Drowsiness
• Vomiting

These side effects are usually temporary and tend to resolve with time. If any side effects persist or worsen, consult a doctor.

Precautions

• Alcohol: Avoid consuming alcohol as it may exacerbate drowsiness and potentially increase stomach acid production.
• Driving/Operating Machinery: This medication may cause dizziness or drowsiness; therefore, refrain from driving or operating machinery until you understand how it affects you.
• Kidney and Liver Conditions: Inform your doctor about any existing kidney or liver issues. Caution is advised for patients with moderate to severe liver impairment.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Use during pregnancy and breastfeeding should only occur if the potential benefits outweigh the risks.
• Children: DOMPAN SR Tablet is generally not recommended for children below 12 years of age as safety and effectiveness have not been established.
• Long-Term Use: Prolonged intake may increase the risk of cyanocobalamin deficiency, Clostridium difficile-associated diarrhea (CDAD), bone fractures, and low magnesium levels. Regular monitoring is advised for long-term treatment.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking, as interactions can occur. For example, CYP3A4 inhibitors (like clarithromycin) can increase domperidone levels, and pantoprazole can affect the absorption of drugs requiring an acidic gastric environment (e.g., ketoconazole, iron supplements, digoxin).

Storage

• Store DOMPAN SR Tablet in a cool and dry place.
• Protect it from direct sunlight and moisture.
• Keep out of sight and reach of children and pets.
• Maintain storage temperatures below 25°C or 30°C.

DOMPAN SR TABLET (10 TAB) is a prescription medicine that combines Domperidone and Pantoprazole to address various digestive issues. It is manufactured by MEDLEY PHARMACEUTICALS LTD.

Here are some frequently asked questions about DOMPAN SR TABLET:

What is DOMPAN SR TABLET used for?

DOMPAN SR TABLET is primarily used to treat conditions related to the stomach and digestive system. These include gastroesophageal reflux disease (GERD), also known as acid reflux, which causes heartburn and chest discomfort. It is also prescribed for dyspepsia (indigestion), gastritis, peptic ulcers, and reflux esophagitis. Additionally, it helps relieve symptoms such as nausea, vomiting, bloating, burping, acidity, and upper abdominal discomfort. This combination medicine is often used when pantoprazole alone cannot effectively control acid reflux.

How does DOMPAN SR TABLET work?

DOMPAN SR TABLET contains two active ingredients: Pantoprazole and Domperidone.

• Pantoprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach by blocking the action of a substance responsible for acid production.
• Domperidone is a prokinetic medicine that works by blocking certain chemical messengers in the gut. This action helps to increase the movement of food from the stomach to the intestines, thereby reducing acid reflux and alleviating nausea and vomiting.

What is the usual dosage for DOMPAN SR TABLET?

The dosage of DOMPAN SR TABLET is determined by a healthcare professional based on the patient's condition, age, and response to treatment. It is typically taken once daily, preferably in the morning, about 15-30 minutes before a meal. The tablet should be swallowed whole with a glass of water and should not be crushed or chewed.

What are the possible side effects of DOMPAN SR TABLET?

Common side effects of DOMPAN SR TABLET may include diarrhea, stomach pain, flatulence (gas), dry mouth, headache, dizziness, drowsiness, and constipation. If these effects persist or worsen, it is important to consult your doctor. More serious, though less common, side effects can include signs of liver problems, severe skin reactions, kidney issues, or symptoms of low magnesium levels (such as tiredness, abnormal muscle movements, or irregular heartbeat).

Is DOMPAN SR TABLET safe during pregnancy or breastfeeding?

Pregnancy: DOMPAN SR TABLET should be used during pregnancy only if considered necessary by a physician, as there is limited information on its effects in pregnant women, and animal studies have shown harmful effects on developing babies. Breastfeeding: The medicine may pass into human breast milk. Therefore, it should not be used by breastfeeding women unless specifically prescribed by the doctor, and only if the potential benefits outweigh the risks. Always consult your doctor before taking this medication if you are pregnant or breastfeeding.

Can DOMPAN SR TABLET be taken with other medications?

It is crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential drug interactions. DOMPAN SR TABLET may interact with certain medications, including:

• Anti-HIV medicines like rilpivirine.
• Antibiotics (e.g., clarithromycin, erythromycin), antifungals (e.g., ketoconazole, fluconazole), and certain heart medications (e.g., verapamil, diltiazem, digoxin) as they can increase domperidone levels and side effects.
• Medicines that require an acidic environment for absorption (e.g., some antifungals, iron supplements, cardiac glycosides), as Pantoprazole reduces stomach acid.
• Immunosuppressants such as methotrexate and certain diuretics.

What precautions should be taken while using DOMPAN SR TABLET?

• Alcohol: Avoid consuming alcohol as it can worsen drowsiness and may increase stomach acid production.
• Driving/Operating Machinery: Do not drive or operate heavy machinery if you experience dizziness or drowsiness.
• Medical Conditions: Inform your doctor if you have kidney or liver disease, heart conditions (e.g., heart failure, irregular heart rhythm), a pituitary gland tumor, or any history of bleeding, blockage, or tears in the gut.
• Long-term Use: Prolonged use may lead to weak bones, deficiency of minerals like magnesium, and an increased risk of certain infections. Your doctor may monitor your kidney and liver function, and magnesium levels, and may recommend calcium and magnesium supplements.
• Lifestyle: Adopting lifestyle changes such as avoiding spicy or fatty foods, hot beverages, and eating smaller, more frequent meals can enhance treatment efficacy. Avoid eating 3-4 hours before bedtime.
• Children: This medicine is generally not recommended for children as its safety and effectiveness have not been established.

What happens if a dose of DOMPAN SR TABLET is missed?

If you miss a dose of DOMPAN SR TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should DOMPAN SR TABLET be stored?

DOMPAN SR TABLET should be stored at room temperature, typically below 25°C or between 10-25°C, and protected from light and moisture. Keep the medicine in its original packaging and out of the sight and reach of children. Do not use the medicine after its expiry date.