Verifica M 50/1000 Tab

VERIFICA M 50/1000 mg Tablet by LUPIN LTD

Name

• Brand Name: VERIFICA M 50/1000 mg Tablet
• Common Name: Vildagliptin and Metformin Hydrochloride Tablets

Composition

• Active Ingredients: Each tablet contains Vildagliptin 50 mg and Metformin Hydrochloride 1000 mg.

Uses

VERIFICA M 50/1000 mg Tablet is prescribed for the management of Type 2 Diabetes Mellitus in adults. It is used when diet and exercise alone, or monotherapy with either vildagliptin or metformin, do not provide adequate blood sugar control. This combination helps improve glycemic control and reduces the risk of serious diabetes-related complications.

Dosage and Administration

Take VERIFICA M 50/1000 mg Tablet orally as directed by your physician. The tablet should be swallowed whole with water, preferably with a meal, and not crushed, chewed, or broken. It is generally recommended to take it regularly at the same time each day, often twice daily. The dosage and duration depend on individual medical conditions and response to treatment. Do not discontinue the medication without consulting your doctor.

Side Effects

• Common Side Effects: Diarrhea, stomach pain/upset, nausea, vomiting, loss of appetite, metallic taste, headache, dizziness, low blood glucose (hypoglycemia, especially when used with other antidiabetic medicines), joint pain, tiredness, constipation, and swollen hands, ankles, or feet (oedema).
• Serious Side Effects: Seek immediate medical attention if you experience symptoms of lactic acidosis (e.g., severe vomiting, stomach pain, difficulty breathing, muscle cramps, severe tiredness, or reduced body temperature) or signs of an inflamed pancreas (severe, persistent abdominal pain with or without nausea or vomiting).

Precautions

• Contraindications: Avoid use if allergic to vildagliptin or metformin, in cases of Type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, congestive heart failure, acute or chronic metabolic acidosis, or excessive alcohol consumption. It is not recommended for children under 18 years of age.
• Pregnancy and Breastfeeding: Not recommended for breastfeeding women. In pregnancy, it should only be used if advised by a doctor, with careful monitoring.
• Alcohol: Avoid alcohol consumption as it can increase the risk of lactic acidosis and affect blood sugar control.
• Driving: Use with caution, as fluctuations in blood sugar levels (too low or too high) or dizziness may affect the ability to drive or operate machinery.
• Interactions: Inform your doctor about all other medications, as interactions may occur (e.g., with other antidiabetic drugs, certain heart medicines, diuretics, or carbonic anhydrase inhibitors). Regular monitoring of blood sugar, kidney function, and liver enzymes is essential during treatment.

Storage

Store the medicine in a cool and dry place, protected from direct sunlight and moisture, preferably below 30°C. Keep it in its original packaging and out of the sight and reach of children.

What is Verifica M 50/1000 Tablet used for?

Verifica M 50/1000 Tablet is a combination medication primarily used for the management of Type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone, or treatment with either metformin or vildagliptin alone, is not sufficient to control blood sugar levels. This medicine helps to improve blood glucose control and can reduce the risk of serious complications associated with diabetes, such as kidney damage, eye damage, nerve problems, limb amputations, and cardiovascular events.

How does Verifica M 50/1000 Tablet work?

Verifica M 50/1000 Tablet contains two active ingredients: Vildagliptin (50 mg) and Metformin (1000 mg).

• Vildagliptin is a DPP-4 inhibitor that works by increasing insulin secretion from the pancreas in a glucose-dependent manner (meaning it acts when blood glucose levels are high) and by reducing glucagon secretion from the pancreas. Glucagon is a hormone that raises blood glucose levels.
• Metformin is a biguanide that lowers glucose production by the liver, decreases the absorption of glucose from the intestines, and enhances the body's sensitivity to insulin, allowing body cells to utilize more circulating blood glucose. Together, these two components help to control blood sugar levels effectively.

What is the usual dosage of Verifica M 50/1000 Tablet?

Verifica M 50/1000 Tablet should be taken exactly as prescribed by your doctor. It is typically recommended to be taken twice daily, usually with or after meals to minimize gastrointestinal discomfort. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. Your doctor will determine the appropriate dose and duration based on your individual condition, age, and response to treatment.

What are the possible side effects of Verifica M 50/1000 Tablet?

Common side effects of Verifica M 50/1000 Tablet may include:

• Hypoglycemia (low blood glucose levels), characterized by dizziness, sweating, hunger pangs, and dry mouth.
• Changes in taste (metallic taste).
• Nausea, vomiting, diarrhea, stomach pain, and loss of appetite.
• Headache, dizziness, and fatigue.
• Joint pain, tiredness, constipation.

Serious but rare side effects include lactic acidosis, which can damage the liver and kidneys. Symptoms of lactic acidosis include vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, severe tiredness, or reduced body temperature. Pancreatitis (inflamed pancreas) is another serious side effect. If you experience any severe or persistent side effects, contact your doctor immediately.

Is Verifica M 50/1000 Tablet safe during pregnancy or breastfeeding?

Verifica M 50/1000 Tablet is generally not recommended during pregnancy unless considered absolutely necessary and advised by your doctor, as there is limited information regarding its safety. Similarly, it is not recommended for use by breastfeeding women because its components are known to pass into breast milk. Always consult your doctor for advice if you are pregnant, planning to conceive, or breastfeeding.

Can Verifica M 50/1000 Tablet be taken with other medications?

Verifica M 50/1000 Tablet can interact with certain medications. It is crucial to inform your doctor about all medicines, supplements, or herbal products you are taking to avoid possible interactions.

• Hyperglycemic medications such as glucocorticoids, beta-2-agonists, and diuretics can counteract the blood sugar-lowering effect of Verifica M.
• ACE-inhibitors (e.g., benazepril, captopril) may increase the risk of hypoglycemia when taken with this medicine.
• Carbonic anhydrase inhibitors (e.g., topiramate) may increase the risk of lactic acidosis.
• Cationic medications like amiloride, digoxin, and morphine may interact with metformin. Your doctor may need to adjust the dosage of your medications or monitor your blood glucose more frequently if you are taking these concurrently.

What precautions should be taken while using Verifica M 50/1000 Tablet?

• Kidney and Liver Conditions: Verifica M is contraindicated in severe kidney disease, end-stage renal disease, or severe liver disease due to the risk of metformin accumulation and lactic acidosis. Your doctor will monitor your kidney and liver function before and during treatment.
• Alcohol Consumption: Avoid consuming alcohol while taking Verifica M, as it can lower blood sugar and significantly increase the risk of lactic acidosis.
• Heart Conditions: Use with caution in patients with heart conditions, including recent heart attack or heart failure.
• Driving and Operating Machinery: This medicine can cause hypoglycemia, leading to dizziness or drowsiness, which may impair your ability to drive or operate machinery. Carry a form of sugar (e.g., juice, chocolate) to manage low blood sugar episodes.
• Type 1 Diabetes: Verifica M is not for the treatment of Type 1 diabetes or diabetic ketoacidosis.
• Stopping Treatment: Do not stop taking Verifica M without consulting your doctor, as abruptly discontinuing the medication can lead to increased blood sugar levels and potential complications.
• Diet and Exercise: It is crucial to continue following the diet and exercise regimen recommended by your doctor while on this medication.

What happens if a dose of Verifica M 50/1000 Tablet is missed?

If you miss a dose of Verifica M 50/1000 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Verifica M 50/1000 Tablet be stored?

Verifica M 50/1000 Tablet should be stored in a cool and dry place, protected from direct sunlight, moisture, and heat. The ideal storage temperature is typically between 10ºC to 25ºC or below 30°C. Always keep this medicine out of the sight and reach of children and pets. Discard any expired or unused medicine properly.