Briv + 100 Mg Tablet (10 Tab)

BRIV + 100 MG TABLET

BRIV + 100 MG TABLET is an anti-epileptic medication manufactured by Dr. Reddy's Laboratories Ltd., used to manage seizures associated with epilepsy.

• Name:

  • Common Name: Brivaracetam 100 mg Tablet
  • Brand Name: BRIV + 100 MG TABLET, Briviact (a commonly known brand for Brivaracetam)

• Composition:

  • Active Ingredient: Brivaracetam 100 mg
  • Each film-coated tablet contains 100 mg Brivaracetam.

• Uses: BRIV + 100 MG TABLET is indicated as adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in adults, adolescents, and children from 1 month of age with epilepsy. It works by suppressing the abnormal electrical activity in the brain, thereby controlling seizures.

• Dosage and Administration: BRIV + 100 MG TABLET is typically taken orally, twice daily, with or without food, but consistency in timing is important. Tablets should be swallowed whole and not crushed, chewed, or broken.

  • Adults and adolescents (16 years and older): Recommended starting dose is usually 50 mg twice daily, with a maximum dose of 100 mg twice daily (200 mg/day).
  • Children (1 month to less than 16 years of age): Dosage is based on body weight and must be determined by a doctor.
  • Hepatic Impairment: Dose adjustments may be necessary for patients with liver problems, with a recommended maximum daily dose of 150 mg.
  • Discontinuation: Do not stop taking this medicine suddenly, as abrupt withdrawal can lead to increased seizure frequency or status epilepticus. Gradual dose reduction under medical supervision is recommended.

• Side Effects: Common side effects may include:

  • Somnolence (drowsiness)
  • Dizziness
  • Fatigue/Tiredness
  • Nausea and Vomiting
  • Irritability

  Serious side effects, though rare, can include:

  • Suicidal thoughts or behaviors
  • Serious allergic reactions (e.g., bronchospasm, angioedema, severe skin rashes like Stevens-Johnson syndrome)
  • Mood and behavior changes (e.g., aggression, anxiety, depression, hostility)
  • Problems with balance and coordination

• Precautions:

  • Patients should be monitored for new or worsening depression, suicidal thoughts or behaviors, and unusual changes in mood or behavior.
  • Avoid driving or operating heavy machinery until you know how the medicine affects you, as it can cause drowsiness, dizziness, and coordination problems.
  • Caution is advised with alcohol consumption as it may increase sedation.
  • Inform your doctor about all medications and supplements being taken, especially carbamazepine (may increase its active metabolite) and rifampin (can reduce brivaracetam levels).
  • Use with caution in patients with hepatic impairment.
  • Consult your doctor if pregnant or breastfeeding, as the safety in pregnancy is not well established.

• Storage: Store BRIV + 100 MG TABLET at room temperature, typically between 15°C to 30°C (59°F to 86°F). Keep out of the sight and reach of children.

What is BRIV + 100 MG TABLET used for?

BRIV + 100 MG TABLET, containing brivaracetam, is an anti-epileptic medicine used to treat partial-onset seizures (fits) in people with epilepsy. It can be used alone or in combination with other medications. It is approved for use in adults and children aged 1 month and older. This medicine helps control seizures for as long as it is taken, but it does not cure epilepsy.

How does BRIV + 100 MG TABLET work?

BRIV + 100 MG TABLET works by binding with high affinity to synaptic vesicle glycoprotein 2A (SV2A) in the brain. This action is believed to be the primary mechanism for its anticonvulsant activity, suppressing abnormal electrical activity of nerve cells and preventing the spread of electrical signals that cause seizures.

What is the usual dosage of BRIV + 100 MG TABLET?

For adults and adolescents 16 years of age and older, the typical starting dosage is 50 milligrams (mg) twice a day. The dose may be adjusted based on individual response and tolerability, usually not exceeding 100 mg twice a day (200 mg per day). For children 1 month to less than 16 years of age, the dose is based on body weight and determined by a doctor. It is important to swallow the tablets whole and not chew or crush them. Patients with liver problems may require a lower starting dose, generally not exceeding 75 mg twice daily (150 mg per day).

What are the possible side effects of BRIV + 100 MG TABLET?

Common side effects include sleepiness, dizziness, feeling tired, nausea, and vomiting. More serious, but rare, side effects can include changes in mood or behavior such as depression, anxiety, anger, irritability, aggression, and suicidal thoughts or behavior. Some individuals may also experience hypersensitivity reactions like bronchospasm (difficulty breathing) and angioedema (swelling of the face, lips, tongue, or throat).

Is it safe during pregnancy or breastfeeding?

There are no adequate data on the developmental risks of brivaracetam in pregnant women, and it is not known if it is safe to take during pregnancy. Animal studies have shown evidence of developmental toxicity at higher exposures. If you become pregnant while taking brivaracetam, you should consult your doctor immediately. A pregnancy registry is available to collect information for those taking antiepileptic drugs during pregnancy.

Brivaracetam passes into breast milk, but the effect on a breastfed infant is unknown. Due to the lack of information, an alternative drug may be preferred, especially for newborns or preterm infants. If brivaracetam is necessary, infants should be monitored for drowsiness, agitation, adequate weight gain, and developmental milestones.

Can it be taken with other medications?

Brivaracetam does not seem to interact with most medications. However, some strong enzyme-inducing antiepileptic drugs like carbamazepine, phenytoin, and phenobarbital/primidone can moderately lower brivaracetam plasma concentrations, though dose adjustment of brivaracetam is usually not needed. Co-administration with carbamazepine may increase the concentration of carbamazepine epoxide, an active metabolite, and a carbamazepine dose reduction might be considered if tolerability issues arise. Rifampin may require a dose adjustment of brivaracetam. Caution should also be used with St. John's wort. Combining brivaracetam with other CNS depressants, including alcohol, can increase sedation and impair psychomotor function, attention, and memory.

What precautions should be taken?

It is important not to stop taking BRIV + 100 MG TABLET suddenly, as this can lead to an increase in seizure frequency or more severe seizures. Your doctor may gradually reduce the dose if discontinuation is necessary.

Since brivaracetam can cause dizziness, drowsiness, and problems with coordination and balance, you should avoid driving or operating machinery until you know how the medicine affects you. Alcohol consumption should be discussed with your doctor, as brivaracetam can worsen alcohol's side effects. Patients with liver problems may need a lower dose.

What happens if a dose is missed?

If you miss a dose of BRIV + 100 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your healthcare provider for advice.

How should it be stored?

BRIV + 100 MG TABLET (tablets) should be stored at room temperature, ideally between 68°F and 77°F (20°C and 25°C), away from heat, moisture, and direct light. Ensure to keep the medicine in its closed container and out of the reach of children.