Pregabid Cr 82.5 Mg Tablet (10 Tab)

PREGABID CR 82.5 MG TABLET (10 TAB)

Name

• Brand Name: PREGABID CR 82.5 MG TABLET
• Common Name/Active Ingredient: Pregabalin (sustained-release)
• Manufacturer: INTAS PHARMACEUTICALS LTD.

Composition

Each tablet contains Pregabalin 82.5 mg as the active ingredient, formulated for sustained release.

Uses

PREGABID CR 82.5 MG TABLET is an anticonvulsant medication primarily used for:

• Neuropathic Pain: Treatment of pain caused by nerve damage, including diabetic peripheral neuropathy, postherpetic neuralgia (pain following shingles), neuropathic pain associated with spinal cord injury, and other peripheral and central neuropathic pain conditions.
• Fibromyalgia: Management of widespread pain, stiffness, and tenderness in muscles, joints, and tendons associated with fibromyalgia syndrome.
• Epilepsy (Seizures/Fits): Used as adjunctive therapy for adult patients with partial-onset seizures.
• Generalized Anxiety Disorder (GAD): May be prescribed for the management of generalized anxiety disorders when other treatments are not effective.

Dosage and Administration

• Take PREGABID CR 82.5 MG TABLET strictly as directed by your doctor. The dosage and duration of treatment will depend on your medical condition and response to the medication.
• Swallow the tablet whole with a glass of water; do not cut, break, crush, or chew it.
• It can be taken with or without food, but it is important to take it at the same time each day, preferably after an evening meal for the CR (controlled-release) formulation, to ensure consistent effectiveness.
• Do not stop taking this medicine suddenly, as it may lead to withdrawal symptoms such as headache, difficulty sleeping, nausea, anxiety, diarrhea, or increased seizure frequency in epileptic patients. Your doctor will advise on a gradual tapering schedule.
• For postherpetic neuralgia, dosing may begin at 165 mg once daily and be increased to 330 mg once daily within one week, with a maximum recommended dose of 660 mg once daily based on patient response and tolerability.

Side Effects

Common Side Effects:

• Dizziness, drowsiness (somnolence), headache
• Dry mouth, blurred vision, or other visual disturbances
• Weight gain, peripheral edema (swelling, especially in the extremities)
• Difficulty with concentration, abnormal thinking
• Increased appetite, fatigue, lethargy
• Constipation, vomiting, flatulence, diarrhea, nausea, stomach discomfort
• Muscle cramps, joint or back pain, pain in limbs
• Tingling or numbness, tremor, difficulty speaking

Serious Side Effects (seek medical attention immediately):

• Allergic reactions such as hives, itching, swelling of the face or other body parts, or difficulty breathing.
• Suicidal thoughts or changes in mood and behavior.
• Severe vision problems or vision loss.

Precautions

• Allergies: Do not take if you are allergic to pregabalin or any other ingredients of PREGABID CR 82.5 MG TABLET.
• Pregnancy and Breastfeeding: Not generally recommended during pregnancy or breastfeeding unless deemed necessary by a physician. Women of childbearing potential should use effective contraception during treatment.
• Driving and Operating Machinery: This medicine can cause dizziness, drowsiness, and blurred vision. Avoid driving or operating heavy machinery until you know how it affects you and you are fully alert.
• Alcohol Consumption: Avoid or limit alcohol consumption during treatment, as it can intensify side effects such as dizziness and drowsiness.
• Medical Conditions: Exercise caution if you have a history of heart problems, diabetes (regularly monitor blood sugar levels), kidney impairment (dose adjustments may be necessary), liver disease, or respiratory disorders. Inform your doctor if you have a history of drug abuse.
• Elderly Patients: Use with caution in elderly patients (over 60-65 years), especially those with kidney problems, as dizziness can increase the risk of accidental falls.
• Pediatric Use: The safety and effectiveness of PREGABID CR 82.5 MG TABLET have not been established in children under 18 years of age, and it is generally not recommended for this age group.
• Drug Interactions: Inform your doctor about all other medications, supplements, or herbal products you are currently taking to avoid potential interactions. Particular caution is advised with medicines for brain-related disorders, sedatives, and opioids (e.g., oxycodone), as co-administration can enhance side effects like sleepiness, dizziness, or lead to memory loss and impaired physical movements.

Storage

Store PREGABID CR 82.5 MG TABLET below 30°C (some sources say below 25°C), protected from light and moisture. Keep out of the sight and reach of children and pets.

PREGABID CR 82.5 MG TABLET contains Pregabalin, an anticonvulsant medication used to manage various neurological conditions. It is manufactured by Intas Pharmaceuticals Ltd..

What is PREGABID CR 82.5 MG TABLET used for?

PREGABID CR 82.5 MG TABLET is primarily used for the prevention and management of neuropathic pain, which is nerve pain caused by nerve damage due to conditions like diabetes, shingles (herpes zoster infection), or spinal cord injury. It is also prescribed for fibromyalgia, a condition characterized by widespread musculoskeletal pain, fatigue, and sleep disturbances. Additionally, it can be used as an add-on therapy for certain types of epilepsy (seizures) and may be prescribed for generalized anxiety disorders when other medications are not effective.

How does PREGABID CR 82.5 MG TABLET work?

Pregabalin, the active ingredient in PREGABID CR 82.5 MG TABLET, works by calming damaged or overactive nerves in the body. It binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, which helps reduce the release of certain excitatory neurotransmitters involved in pain signals and neuronal excitability. This action helps to reduce pain, improve sleep, and alleviate symptoms associated with nerve damage and seizures.

What is the usual dosage of PREGABID CR 82.5 MG TABLET?

PREGABID CR 82.5 MG TABLET is an extended-release formulation, typically taken once daily after an evening meal. The dosage and duration of treatment depend on the medical condition and the patient's response. For conditions like diabetic peripheral neuropathy or postherpetic neuralgia, dosing often begins at 165 mg once daily and may be increased to a maximum recommended dose of 330 mg once daily within a week, based on efficacy and tolerability. In some cases, for postherpetic neuralgia, the dose may be increased up to 660 mg once daily if needed and tolerated. It is crucial to follow your doctor's instructions, as they will likely start with a low dose and gradually increase it.

What are the possible side effects of PREGABID CR 82.5 MG TABLET?

Common side effects of PREGABID CR 82.5 MG TABLET include dizziness, sleepiness (somnolence), dry mouth, blurred vision, weight gain, swelling (edema), and difficulties with concentration or attention. Other reported side effects can include headache, increased appetite, elevated mood, confusion, tremor, tingling or numbness, constipation, vomiting, diarrhea, muscle cramps, joint pain, and suicidal thoughts. Most side effects are mild and resolve on their own, but if they persist or worsen, it is important to consult your doctor.

Is PREGABID CR 82.5 MG TABLET safe during pregnancy or breastfeeding?

PREGABID CR 82.5 MG TABLET is generally not recommended during pregnancy unless specifically advised by a doctor, who will weigh the potential benefits against the risks. Women of childbearing age are advised to use effective contraception while taking this medicine. During breastfeeding, Pregabalin passes into breast milk, and its effect on the baby is unknown, so a doctor will determine whether to discontinue breastfeeding or the medication based on individual circumstances.

Can it be taken with other medications?

PREGABID CR 82.5 MG TABLET can interact with other medications, potentially increasing side effects like dizziness or drowsiness. It is crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking or plan to take. Particular caution is advised with strong opioids (e.g., oxycodone) and benzodiazepines (e.g., lorazepam), as these combinations can enhance sedative effects and lead to memory loss or impaired physical movement.

What precautions should be taken?

Several precautions should be taken while using PREGABID CR 82.5 MG TABLET. Avoid consuming alcohol, as it can increase sleepiness and dizziness. Due to potential dizziness, sleepiness, and blurred vision, avoid driving or operating machinery until you know how the medicine affects you. Inform your doctor if you have heart problems, diabetes, kidney issues, liver disease, respiratory disorders, a history of drug abuse, or mood disorders. There is a risk of suicidal thoughts, so report any mood changes or thoughts of self-harm to your doctor immediately. Do not stop taking this medicine abruptly, as it can lead to withdrawal symptoms or worsen your condition; the dose should be gradually reduced under medical supervision.

What happens if a dose is missed?

If you miss a dose of PREGABID CR 82.5 MG TABLET after an evening meal, you should take the prescribed dose prior to bedtime following a snack. If you miss a dose prior to bedtime, take it following a morning meal. If you miss a dose following a morning meal, take it at the usual time that evening after an evening meal. Do not double the dose to make up for a missed one.

How should it be stored?

PREGABID CR 82.5 MG TABLET should be stored below 30°C, protected from light and moisture. Keep it out of the reach of children and pets.