Tenali M 1000 Mg (10 Tab)

TENALI M 1000 MG

by CADILA PHARMACEUTICALS LIMITED

Name:

• Brand Name: TENALI M 1000 MG (also referred to as Tenali M 1000mg/20mg Tablet ER, Tenali M 1000 Tablet)
• Manufacturer: Cadila Pharmaceuticals Limited

Composition: TENALI M 1000 MG contains two active ingredients:

• Metformin Hydrochloride: 1000 mg
• Teneligliptin: 20 mg

Uses: TENALI M 1000 MG is an antidiabetic medication primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed to improve blood sugar control, especially when diet and exercise alone, or metformin alone, are insufficient. This combination medication helps in lowering blood glucose levels, enhancing insulin sensitivity, reducing the amount of glucose produced by the liver, and decreasing glucose absorption from the intestines. Effective management of blood sugar levels helps prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, heart attack, or stroke.

Dosage and Administration: TENALI M 1000 MG tablets are for oral administration. They should be taken as directed by a healthcare professional, typically with food to minimize the chance of stomach upset. The tablet should be swallowed whole and not crushed, chewed, or broken. It is usually recommended to take it regularly, at the same time each day, for optimal benefit, and treatment should not be stopped without consulting a doctor.

Side Effects: Common side effects may include:

• Diarrhea
• Nausea
• Vomiting
• Hypoglycemia (low blood sugar), which can cause dizziness, sweating, and confusion
• Headache
• Stomach ache or upset
• Respiratory tract infection

Serious but rare side effects include lactic acidosis, which requires immediate medical attention. Long-term use may also lead to Vitamin B12 deficiency.

Precautions:

• Contraindications: Avoid use in patients with known allergy to Metformin or Teneligliptin, severe renal impairment, liver impairment, congestive heart failure, lactic acidosis, diabetic ketoacidosis, type 1 diabetes mellitus, severe uncontrollable diabetes, alcoholism, or severe systemic infections.
• Pregnancy and Breastfeeding: Not recommended for use during pregnancy or while breastfeeding due to potential risks to the baby.
• Alcohol: Excessive alcohol consumption increases the risk of lactic acidosis.
• Drug Interactions: Caution is advised when co-administering with certain medications like corticosteroids, cimetidine, dolutegravir, ranolazine, NSAIDs, verapamil, rifampicin, and olaparib, as these may alter metformin levels or affect blood sugar lowering effects.
• Other Warnings: Inform your doctor if you have pituitary insufficiency, adrenal insufficiency, are malnourished, on an irregular diet, perform extreme muscle exercises, have a history of abdominal surgery or intestinal obstruction, or have hypokalaemia. Regular monitoring of kidney and liver function is important.

Storage: Store TENALI M 1000 MG at room temperature, between 15 to 30°C (or below 30°C), in a dry and dark place. Keep it protected from direct light, moisture, and heat. Always keep this medicine out of reach of children and pets. Do not use expired or damaged medicines.

Here are frequently asked questions about TENALI M 1000 MG, a medication manufactured by Cadila Pharmaceuticals Limited:

What is TENALI M 1000 MG used for?

TENALI M 1000 MG is an antidiabetic medication primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus. It is often prescribed when diet and exercise alone, or treatment with metformin alone, are not sufficient to control blood sugar. This medication helps to prevent serious complications associated with diabetes, such as kidney damage, blindness, heart attack, and stroke.

How does TENALI M 1000 MG work?

TENALI M 1000 MG contains two active ingredients: Metformin (1000 mg) and Teneligliptin (20 mg).

• Metformin (a biguanide) works by reducing the production of glucose in the liver, decreasing the absorption of glucose from the intestines, and increasing the body's sensitivity to insulin.
• Teneligliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor) works by increasing the levels of incretin hormones (like GLP-1 and GIP), which stimulate the pancreas to release more insulin when blood glucose levels are high and reduce glucagon secretion. Together, these actions lead to better control of both fasting and post-meal blood sugar levels.

What is the usual dosage for TENALI M 1000 MG?

TENALI M 1000 MG should be taken as directed by your doctor. It is typically consumed with food to help reduce stomach upset. You should swallow the tablet whole with a glass of water and not crush, chew, or break it. The exact dose and duration of treatment will depend on your condition, blood sugar levels, and other medications you may be taking, as determined by your physician.

What are the possible side effects of TENALI M 1000 MG?

Common side effects may include diarrhea, nausea, vomiting, headache, and hypoglycemia (low blood sugar). Other possible side effects are stomach ache, respiratory infection, weight gain, sweating, constipation, and altered taste sensations. A rare but serious side effect is lactic acidosis, which can cause symptoms like muscle pain, dizziness, tiredness, difficulty breathing, and stomach pain. Long-term use may also lead to Vitamin B12 deficiency. If you experience any severe or persistent side effects, or symptoms of lactic acidosis, consult your doctor immediately.

Is TENALI M 1000 MG safe during pregnancy or breastfeeding?

TENALI M 1000 MG is generally not recommended for use during pregnancy as its safety has not been established and animal studies have shown harmful effects on the developing baby. For breastfeeding mothers, it is also not recommended, as the drug may pass into breast milk and potentially harm the infant. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding, to weigh the benefits against potential risks.

Can TENALI M 1000 MG be taken with other medications?

TENALI M 1000 MG can interact with certain other medications. For instance, cationic medicines (like amiloride, cimetidine, ranitidine) can increase metformin levels, raising the risk of lactic acidosis. Other medications that may interact include NSAIDs (like ibuprofen), certain blood pressure medications (like enalapril), steroids (like corticosteroids), certain antibiotics (like rifampicin), and medicines for fungal infections (like fluconazole). It is crucial to inform your doctor about all medicines, herbal preparations, and supplements you are taking to avoid potential interactions.

What precautions should be taken while using TENALI M 1000 MG?

Avoid consuming alcohol while taking this medicine, as it can increase the risk of lactic acidosis. Inform your doctor if you have kidney, liver, or heart problems, severe infection, or are planning surgery. This medicine is contraindicated in patients with severe renal impairment, severe liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis. Regular monitoring of blood sugar levels is important, especially when combined with other antidiabetic medicines, to avoid hypoglycemia.

What happens if a dose of TENALI M 1000 MG is missed?

If you miss a dose of TENALI M 1000 MG, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Always consult your doctor before making any changes to your dosage regimen.

How should TENALI M 1000 MG be stored?

Store TENALI M 1000 MG at room temperature, typically between 15 to 30°C (or below 30°C). Keep the medicine in a dry, dark place, away from direct light and moisture. Always keep it out of the reach of children. Ensure the medicine is used before its expiry date.