Solonex Dt Tablet ( 10 Tab )

SOLONEX DT TABLET (10 TAB) by MACLEODS PHARMACEUTICALS LTD.

Name

• Brand Name: SOLONEX DT Tablet
• Common Name: Isoniazid (active ingredient)

Composition

• Active Ingredient: Isoniazid 100mg (as per SOLONEX DT 100MG TABLET references)

Uses SOLONEX DT Tablet is an anti-tubercular agent primarily used for the treatment and prevention of tuberculosis (TB), including both active and inactive (latent) forms. It effectively targets and eliminates Mycobacterium tuberculosis bacteria by inhibiting the production of mycolic acid, which is essential for bacterial cell wall formation.

Dosage and Administration

• SOLONEX DT Tablet should be taken orally on an empty stomach, ideally at least 1 hour before or 2 hours after a meal, with a glass of water.
• The dose and duration of treatment are determined by a healthcare professional based on the patient's body weight and medical condition.
• It is crucial to complete the entire prescribed course of treatment, even if symptoms improve, to prevent treatment failure and the development of drug resistance. Do not skip doses or take a double dose to compensate for a missed one.

Side Effects

• Common Side Effects: Fever, dizziness, nausea, stomach upset, loss of appetite, constipation, tiredness, weakness, lethargy, skin rash, joint pain. A common side effect is peripheral neuropathy, characterized by tingling, burning sensation, and numbness in the hands and feet.
• Serious Side Effects (Consult a doctor immediately if experienced): Signs of liver damage (jaundice, yellowing of eyes or skin, dark urine, stomach pain, joint pain), hepatitis, increased liver enzymes, mental health problems, fits (seizures), optic neuritis (swelling of the optic nerve that may cause vision loss), or severe allergic reactions (fever, chills, rashes, swelling of the face and tongue).

Precautions

• Inform your doctor about any allergies to isoniazid or other components of the medicine.
• Patients with pre-existing conditions such as liver disease, kidney disease, diabetes, HIV infection, malnutrition, or a history of psychosis or fits should inform their doctor before taking this medicine.
• Pregnant or breastfeeding women should consult their doctor before use, as the medicine crosses the placenta and can be used cautiously for active TB, with monitoring of the newborn.
• Avoid alcohol consumption during treatment as it can increase the risk of liver damage and severe side effects.
• Avoid consuming tyramine-rich foods (e.g., aged cheese, smoked fish/meats, certain beers, red wine, soy, tuna, salmon, mackerel) as they may interact with the medication.
• Vitamin B6 (pyridoxine) supplementation is often advised to counteract peripheral neuropathy.
• SOLONEX DT Tablet may cause side effects such as mental health problems, fits, or vision loss, which could impair the ability to drive or operate machinery.
• Regular monitoring of liver function tests is recommended during treatment.

Storage Store SOLONEX DT Tablet at room temperature (20-25 degrees Celsius) away from light and moisture. Keep out of reach and sight of children.

Here are frequently asked questions and answers about SOLONEX DT TABLET.

What is SOLONEX DT TABLET used for?

SOLONEX DT TABLET is an antibiotic primarily used to treat and prevent tuberculosis (TB), including both active and latent forms of the infection. Tuberculosis is a serious bacterial disease that commonly affects the lungs but can also spread to other parts of the body, such as the kidneys, brain, spine, and bone marrow.

How does SOLONEX DT TABLET work?

SOLONEX DT TABLET contains Isoniazid, which works by preventing bacteria from producing mycolic acid. Mycolic acid is a crucial component required for the formation of the bacterial cell wall (protective coating). By disrupting mycolic acid synthesis and interfering with bacterial cell metabolism, Isoniazid kills the Mycobacterium tuberculosis bacteria that cause TB, thereby inhibiting the spread of infection.

What is the usual dosage for SOLONEX DT TABLET?

The dose and duration of SOLONEX DT TABLET should be strictly as advised by your doctor, based on your body weight and medical condition. It is typically taken orally on an empty stomach, at least one hour before or two hours after a meal, to ensure proper absorption. For adults, a common dosage is 5 mg/kg up to 300 mg daily as a single dose, or 15 mg/kg up to 900 mg/day, two or three times weekly. For children, it's usually 10-15 mg/kg up to 300 mg daily or 20-40 mg/kg up to 900 mg/day, two or three times weekly. It's crucial to complete the entire course of treatment to prevent the development of drug resistance.

What are the possible side effects of SOLONEX DT TABLET?

Common side effects can include peripheral neuropathy (tingling, burning sensation, and numbness in hands and feet), loss of appetite, nausea, vomiting, stomach upset, dizziness, and unusual tiredness or weakness. More serious side effects, though less common, can include liver damage (jaundice, elevated liver enzymes, dark urine, stomach pain), mental health problems, convulsions (fits), or optic neuritis (swelling of the optic nerve that may cause vision loss). If you experience any persistent or worsening side effects, especially signs of liver problems or vision changes, consult your doctor immediately.

Is SOLONEX DT TABLET safe during pregnancy or breastfeeding?

If you are pregnant or breastfeeding, it is imperative to consult your doctor before taking SOLONEX DT TABLET. While it may be considered unsafe during pregnancy with limited human studies showing harmful effects on developing babies, your doctor may prescribe it if the benefits outweigh the risks. In breastfeeding women, the drug is generally considered safe if prescribed, as it is excreted in breast milk in low quantities and is not typically harmful to the baby. However, appropriate Vitamin B6 supplementation for the mother under medical supervision is recommended if the medicine is used during breastfeeding.

Can SOLONEX DT TABLET be taken with other medications?

SOLONEX DT TABLET is often used in combination with other anti-tubercular agents as part of a multidrug regimen. It's crucial to inform your doctor about all medications you are currently taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions. Notably, concurrent use of a Vitamin B6 (pyridoxine) supplement is often prescribed to help prevent peripheral neuropathy, a common side effect. Multidrug treatments for tuberculosis that include rifampin can decrease the effectiveness of oral contraceptives. SOLONEX DT TABLET itself has no known serious interactions with commonly used oral contraceptives or with ibuprofen, paracetamol, naproxen, or amoxicillin.

What precautions should be taken while on SOLONEX DT TABLET?

Avoid alcohol consumption while taking SOLONEX DT TABLET as it can increase the risk of liver damage and other severe side effects. It's also important to avoid foods and drinks high in tyramine, such as aged cheese, cured meats, smoked fish, soy, tuna, salmon, mackerel, red wine, and certain beers, as they may interact with the medication and potentially lead to increased blood pressure. Inform your doctor if you have a history of liver disease, kidney disease, diabetes, HIV infection, malnutrition, convulsive disorders, or psychosis. Do not drive or operate heavy machinery if you experience side effects like dizziness, mental health problems, or vision changes.

What happens if a dose of SOLONEX DT TABLET is missed?

If you miss a dose of SOLONEX DT TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to compensate for a missed one.

How should SOLONEX DT TABLET be stored?

SOLONEX DT TABLET should be stored at room temperature, typically between 20-25°C (68-77°F). It should be protected from moisture and light, and kept out of the reach and sight of children.