Glura M 1000

GLURA M 1000, manufactured by Eris Lifesciences Limited, is a combination medication primarily used in the management of type 2 diabetes mellitus. It helps to control high blood sugar levels when diet and exercise alone are insufficient.

Name

• Brand Name: GLURA M 1000 Tablet

Composition

GLURA M 1000 contains two active ingredients:

• Metformin Hydrochloride: 1000 mg
• Sitagliptin: 50 mg

Metformin works by reducing glucose production in the liver, decreasing intestinal glucose absorption, and enhancing the body's sensitivity to insulin. Sitagliptin, a DPP-4 inhibitor, increases the levels of incretin hormones, which helps increase insulin release and reduce glucagon levels in a glucose-dependent manner.

Uses

GLURA M 1000 is prescribed for:

• Controlling high blood sugar levels in adults with type 2 diabetes mellitus.
• Improving overall glycemic control.
• Lowering the risk of diabetes-related complications such as kidney damage, eyesight loss (retinopathy), nerve damage (neuropathy), heart problems, and stroke.

Dosage and Administration

• Typically taken with food to minimize stomach upset.
• Swallow the tablet whole with water; do not crush, chew, or break it.
• The exact dose and duration of therapy are determined by a physician based on the patient's age, body weight, and medical condition. It is often taken once or twice daily.
• It is crucial to follow a healthy diet and engage in regular physical exercise alongside this medication for better results.

Side Effects

Common Side Effects:

• Low blood sugar levels (hypoglycemia) – symptoms include increased hunger, sweating, shakiness, weakness, dizziness, and irregular heartbeat.
• Stomach upset, nausea, vomiting, diarrhea, abdominal pain, flatulence.
• Metallic taste in the mouth.
• Headache, sore throat, stuffy nose, upper respiratory tract infections.
• Joint pain.

Serious Side Effects:

• Lactic acidosis (a rare but serious condition that can damage the liver and kidneys) – symptoms include muscle pain, weakness, dizziness, cold hands/feet, breathing difficulties, stomach pain, nausea, vomiting, and a slow heartbeat.
• Pancreatitis (inflammation of the pancreas).
• Severe allergic reactions (e.g., hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing).
• Severe blistering of the skin (bullous pemphigoid).

Precautions

• Contraindications: Not recommended for patients with severe, uncontrolled diabetes, type 1 diabetes mellitus, diabetic ketoacidosis, severe kidney or liver problems, severe systemic infections, alcoholism, or shock.
• Pregnancy and Breastfeeding: Generally not recommended for use during pregnancy or by breastfeeding women. Consult a doctor immediately if pregnant, planning pregnancy, or breastfeeding.
• Liver/Kidney/Heart Problems: Inform your doctor if you have any pre-existing liver, kidney, or heart conditions.
• Alcohol Consumption: Avoid alcohol as it may increase the risk of lactic acidosis and other side effects.
• Drug Interactions: Inform your doctor about all other medicines you are taking, including antidiabetics (e.g., insulin, sulfonylureas), diuretics, corticosteroids, NSAIDs, and certain heart medications.
• Monitoring: Regular monitoring of blood sugar levels and kidney function may be required during therapy.
• Driving: May cause dizziness; avoid driving or operating machinery if affected.
• Vitamin B12 levels: Long-term use may lower vitamin B12 levels.
• Do not stop taking the medicine abruptly without consulting a doctor, as this can lead to increased blood sugar levels and worsen complications.

Storage

• Store below 30°C.
• Keep away from direct sunlight and moisture.
• Ensure it is out of the sight and reach of children and pets.
• Discard any expired tablets.

GLURA M 1000 is a medication manufactured by Eris Lifesciences Limited, primarily used for the management of Type 2 Diabetes Mellitus. It combines two active ingredients, sitagliptin and metformin, to help control blood sugar levels.

Here are some frequently asked questions about GLURA M 1000:

1. What is GLURA M 1000 used for?

GLURA M 1000 is used to manage Type 2 Diabetes Mellitus in adults. It helps control blood sugar levels when diet and exercise alone are not sufficient. This medication aims to improve glycemic control by reducing both fasting and post-meal blood glucose concentrations, enhancing insulin sensitivity, and decreasing glucose production by the liver. It can also help reduce the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, heart issues, and stroke.

2. How does GLURA M 1000 work?

GLURA M 1000 contains two active ingredients:

• Sitagliptin (50 mg): This component is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of natural substances called incretins, which help to lower blood sugar when it is high by stimulating insulin release from the pancreas and reducing glucagon secretion.
• Metformin (1000 mg): This biguanide works by reducing glucose production in the liver, decreasing the absorption of glucose from the intestines, and enhancing the body's sensitivity to insulin, allowing for more effective glucose utilization. Together, they provide better control of blood sugar.

3. What is the usual dosage for GLURA M 1000?

The dosage of GLURA M 1000 is determined by your doctor based on your individual condition, blood sugar levels, and other medications you might be taking. It should be taken exactly as prescribed by your doctor, usually swallowed whole with a glass of water during meals. Do not break, chew, or crush the tablet.

4. What are the possible side effects of GLURA M 1000?

Common side effects may include diarrhea, nausea, vomiting, abdominal pain, headache, flatulence, upper respiratory tract infections, and low blood sugar levels (hypoglycemia). More serious, though rare, side effects can include lactic acidosis (a dangerous build-up of acid in the blood) and severe allergic reactions. If you experience persistent or severe side effects, or symptoms like severe abdominal pain, difficulty breathing, or unusual muscle pain, consult your doctor immediately.

5. Is GLURA M 1000 safe during pregnancy or breastfeeding?

Caution is advised regarding the use of GLURA M 1000 during pregnancy. It may be unsafe, and some components can cause harm to an unborn baby. For breastfeeding mothers, the components of GLURA M 1000, particularly metformin, are known to be excreted into human breast milk. It is considered probably unsafe during breastfeeding, and your doctor may advise whether to discontinue breastfeeding or stop the medication based on your specific situation. Always consult your doctor before using this medicine if you are pregnant, planning to conceive, or breastfeeding.

6. Can GLURA M 1000 be taken with other medications?

GLURA M 1000 can interact with various other medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking or plan to take. Interactions may occur with:

• Other anti-diabetic medicines (like glimepiride, glibenclamide, insulin) which can increase the risk of hypoglycemia.
• Diuretics (like furosemide) and cationic medicines (like digoxin, morphine, vancomycin) which may alter metformin's effectiveness.
• Calcium channel blockers (like nifedipine) which might increase blood glucose levels.
• Certain steroids, bronchodilators, NSAIDs, and iodine contrast mediums. Alcohol consumption should be avoided as it increases the risk of lactic acidosis and can affect blood sugar control.

7. What precautions should be taken while using GLURA M 1000?

Before taking GLURA M 1000, inform your doctor if you have kidney, liver, or heart problems, a history of pancreatitis, or low vitamin B12 levels. It is not recommended for individuals with Type 1 diabetes, severe kidney or liver disease, metabolic acidosis, severe dehydration, or alcoholism. Regular monitoring of kidney function and blood sugar levels is essential during treatment.

8. What happens if a dose of GLURA M 1000 is missed?

If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Never double your dose to make up for a missed one.

9. How should GLURA M 1000 be stored?

GLURA M 1000 should be stored below 30°C. Keep it away from direct sunlight and moisture, and ensure it remains out of the reach of children. Always check the expiry date before use and discard any expired tablets.