Aceret 25

ACERET 25 Capsule

ACERET 25 is a medication manufactured by Glenmark Pharmaceuticals Ltd. used primarily for severe skin conditions.

• Name:

  • Brand Name: ACERET 25
  • Common Name: Acitretin (active ingredient)

• Composition:

  • Each capsule contains Acitretin 25 mg.

• Uses: ACERET 25 is a retinoid, similar to vitamin A, that helps normalize skin cell growth. It is prescribed for:

  • Psoriasis: Severe cases where the skin is thick, scaly, itchy, and red, and doesn't respond to other treatments. It reduces rapid skin cell growth, scaling, redness, and thickness.
  • Other Keratinization Disorders: Including ichthyosis (dry, thickened, scaly skin) and Darier's disease (persistent crusted or scaly spots), and pityriasis.

• Dosage and Administration: ACERET 25 should be taken orally once daily with food or a glass of milk, swallowed whole without crushing or chewing. The dosage and duration depend on the patient's condition and response, as advised by a doctor. Do not stop treatment abruptly.

• Side Effects: Common side effects include dry lips, mouth dryness, peeling skin (especially palms and soles), hair loss, itching, nosebleeds, eye irritation (conjunctivitis), joint pain, and elevated blood fat levels. More serious, though rare, side effects can include vision problems (especially at night), mood changes, depression, and liver damage.

• Precautions:

  • Pregnancy and Breastfeeding: ACERET 25 is highly unsafe during pregnancy and is contraindicated for pregnant and breastfeeding women due to the risk of severe birth defects. Effective contraception must be used during treatment and for three years after stopping the medication.
  • Alcohol: Avoid alcohol consumption during and for three years after treatment, as it can increase side effects and lead to the formation of a long-acting teratogenic metabolite.
  • Sun Sensitivity: The medication increases skin sensitivity to sunlight; use sunscreen and protective clothing.
  • Medical Conditions: Use with caution in patients with liver or kidney impairment, diabetes (can alter blood glucose), high cholesterol, and those with a history of mental health problems.
  • Other Medications: Inform your doctor about all other medications, especially other retinoids, vitamin A supplements, tetracycline antibiotics, and methotrexate.
  • Blood Donation: Do not donate blood during treatment or for three years after discontinuing ACERET 25.
  • Driving/Operating Machinery: May cause dizziness, blurred vision, or decreased night vision; avoid these activities if affected.

• Storage: Store ACERET 25 below 25-30°C in a cool, dry place, protected from light and moisture. Keep it out of reach of children.

Here are some frequently asked questions about ACERET 25:

What is ACERET 25 used for?

ACERET 25, containing Acitretin, is primarily used to treat severe and extensive forms of psoriasis, a chronic autoimmune skin condition characterized by red, scaly, and itchy patches on the skin. It is prescribed when other conventional treatments have not been effective. It can also be used for other severe keratinization disorders such as ichthyosis (dry, thickened, scaly skin) and Darier's disease (persistent crusted or scaly spots).

How does ACERET 25 work?

ACERET 25 is a retinoid, a derivative of vitamin A, with anti-inflammatory and antiproliferative properties. It works by regulating skin cell growth and normalizing keratinocyte differentiation, effectively slowing down the excessive growth and thickening of skin cells that occurs in conditions like psoriasis. This action helps to reduce the redness, scaling, and thickness of psoriatic rashes and improves the overall appearance of the affected skin.

What is the usual dosage for ACERET 25?

The dosage of ACERET 25 is determined by a doctor based on the patient's condition and response to treatment. It is generally taken once daily with food or a glass of milk to enhance absorption. For severe psoriasis, an initial dose may range from 25 to 50 mg orally daily, with maintenance doses also typically falling within this range after initial response. It's crucial to follow the doctor's instructions precisely and not to stop the medication without consulting them, as symptoms may recur or worsen.

What are the possible side effects of ACERET 25?

Common side effects of ACERET 25 include dry lips, dry skin, skin peeling (especially on palms and soles), hair loss, nail disorders, nosebleeds, and eye irritation (conjunctivitis or dry eyes). Other reported side effects can include joint pain, muscle ache, increased thirst, reddening of the skin, itching, burning sensation, and a feeling of cold. Most side effects are temporary and may resolve upon discontinuing treatment, but if any persist or worsen, immediate medical advice should be sought. ACERET 25 can also cause dizziness and drowsiness, and may affect night vision.

Is ACERET 25 safe during pregnancy or breastfeeding?

No, ACERET 25 is highly unsafe and strictly contraindicated during pregnancy, as it can cause severe birth defects and harm to the unborn baby. Women of childbearing potential must use effective and reliable contraception during treatment and for at least three years after discontinuing the medication, even if their periods are irregular or they are not sexually active. Regular pregnancy tests are often advised during this period. ACERET 25 is also contraindicated for breastfeeding mothers, as it may pass into breast milk and potentially harm the nursing baby.

Can ACERET 25 be taken with other medications?

ACERET 25 can interact with several medications. It should not be taken with tetracycline antibiotics (which can increase the risk of a condition called pseudotumor cerebri), methotrexate (used for cancer, psoriasis, and rheumatoid arthritis), or other retinoid medicines and vitamin A supplements (exceeding 5000 IU per day), as this can lead to additive toxicity and increased side effects. The contraceptive efficacy of progestin-only contraceptives (mini-pills) might also be reduced when taken with ACERET 25. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using ACERET 25?

Several precautions are necessary when taking ACERET 25:

• Alcohol: Avoid alcohol consumption during treatment and for at least two months (or even three years in women of childbearing potential) after stopping the medicine, as it can increase side effects and lead to the formation of a long-acting teratogenic metabolite called etretinate.
• Sun Exposure: ACERET 25 can increase skin sensitivity to sunlight. Avoid strong sunlight and sunbeds, and use protective clothing and sunscreen when outdoors.
• Driving/Operating Machinery: The medication may cause dizziness, drowsiness, or vision problems, especially in the dark. Avoid driving or operating heavy machinery if you experience these effects.
• Liver and Kidney Function: ACERET 25 should be used with caution in patients with liver or kidney disease, and dose adjustments may be needed. Your doctor may recommend regular blood tests to monitor liver function and blood fat levels.
• Mental Health: In rare cases, ACERET 25 may cause depression or suicidal thoughts. Inform your doctor immediately if you notice mood changes.
• Blood Donation: Do not donate blood during treatment and for at least three years after stopping ACERET 25, as it could harm an unborn child if the blood is transfused to a pregnant woman.

What happens if a dose of ACERET 25 is missed?

If you miss a dose of ACERET 25, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should ACERET 25 be stored?

ACERET 25 capsules should be stored at a cool temperature, typically below 25°C or 30°C, and protected from light and moisture. Keep the medicine in an airtight container and out of reach of children and pets.