Piohope 15 Mg Tablet (10 Tab)

PIOHOPE 15 MG TABLET

PIOHOPE 15 MG TABLET is an oral antidiabetic medication manufactured by Mankind Pharma Ltd., used to manage type 2 diabetes mellitus in adults.

• Composition Each tablet contains Pioglitazone 15 mg as its active ingredient. Pioglitazone belongs to the thiazolidinedione class of antidiabetic medicines.

• Uses PIOHOPE 15 MG TABLET is primarily used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels by improving the body's response to insulin and enhancing insulin sensitivity in muscle, fat, and liver cells. This aids in preventing serious complications associated with uncontrolled diabetes, such as kidney damage, blindness, nerve problems, and cardiovascular issues. It is often prescribed when diet, exercise, and other first-line oral antidiabetic medicines like metformin do not yield an adequate response, and can be used alone or with other diabetes medications.

• Dosage and Administration Take PIOHOPE 15 MG TABLET exactly as advised by your doctor. It is typically taken orally once daily, with or without food, preferably at the same time each day to maximize benefits. Do not crush, chew, or break the tablet; swallow it whole with a glass of water. Consistent intake is crucial for effective blood sugar control.

• Side Effects Common side effects may include headache, muscle pain (myalgia), sinusitis, pharyngitis, and weight gain. More serious, though rare, side effects can include fluid retention (oedema) leading to heart failure, liver problems, and an increased risk of bladder cancer. Hypoglycemia (low blood sugar) is also a possible side effect, especially when used with other diabetes medications.

• Precautions PIOHOPE 15 MG TABLET is not recommended for individuals with type 1 diabetes, diabetic ketoacidosis, or severe kidney or liver disease. It should be used with caution in patients with a history of heart disease, heart failure, thyroid disorders, or certain hormonal conditions. Pregnant or breastfeeding women should consult their doctor before taking this medication. Regular monitoring of blood sugar levels and liver function is advised during treatment. Alcohol consumption should be limited.

• Storage Store PIOHOPE 15 MG TABLET in a cool and dry place, ideally below 30°C. Protect it from direct sunlight, moisture, and heat, and keep it out of sight and reach of children.

What is PIOHOPE 15 MG TABLET used for?

PIOHOPE 15 MG TABLET, containing Pioglitazone, is an anti-diabetic medication used to treat type 2 diabetes mellitus in adults. It is prescribed as an adjunct to diet and exercise to help control high blood sugar levels. It can be used alone or in combination with other medications like metformin, sulfonylureas, or insulin.

How does PIOHOPE 15 MG TABLET work?

PIOHOPE 15 MG TABLET works by improving the body's sensitivity to insulin. Its active ingredient, Pioglitazone, is a thiazolidinedione that activates peroxisome proliferator-activated receptor-gamma (PPAR-γ) in fat, muscle, and liver cells. This action helps reduce insulin resistance in the liver and peripheral tissues, leading to increased glucose uptake and utilization by the cells, and decreased glucose production in the liver.

What is the usual dosage for PIOHOPE 15 MG TABLET?

The usual starting dose is 15 mg or 30 mg once daily, taken orally with or without food. Your doctor may adjust the dose based on your glycemic response, but it typically should not exceed 45 mg once a day.

What are the possible side effects of PIOHOPE 15 MG TABLET?

Common side effects can include swelling (edema), low blood sugar (hypoglycemia, especially when taken with insulin or sulfonylureas), upper respiratory tract infection, headache, sinus infection, sore throat, and muscle pain. More serious side effects may include heart failure, increased risk of bladder cancer (especially with prolonged use), weight gain, and bone fractures in women. Patients should also be monitored for liver problems and visual changes.

Is PIOHOPE 15 MG TABLET safe during pregnancy or breastfeeding?

PIOHOPE 15 MG TABLET is generally not recommended during pregnancy, and its safety in this period is not well-established due to potential risks. For breastfeeding, it is unknown whether Pioglitazone passes into human milk, although it is highly protein-bound, making passage into breastmilk in clinically significant amounts unlikely. It is crucial to discuss the risks and benefits with your doctor if you are pregnant or breastfeeding.

Can PIOHOPE 15 MG TABLET be taken with other medications?

Yes, PIOHOPE 15 MG TABLET can be used in combination with other antidiabetic medications like metformin, sulfonylureas, or insulin. However, if taken with insulin or insulin secretagogues, a reduction in the dose of the other antidiabetic medication may be necessary to reduce the risk of low blood sugar. It can also interact with certain medications that affect liver enzymes (CYP2C8 inhibitors or inducers), which may require dose adjustments.

What precautions should be taken while taking PIOHOPE 15 MG TABLET?

Before taking PIOHOPE 15 MG TABLET, inform your doctor if you have a history of heart failure (as it can cause or worsen it), active bladder cancer or a history of it, or liver problems. Women should be aware of an increased risk of bone fractures and the potential for ovulation in premenopausal anovulatory women, which could increase the chance of pregnancy. Regular eye exams are also important if you experience any visual symptoms.

What happens if a dose of PIOHOPE 15 MG TABLET is missed?

If you miss a dose of PIOHOPE 15 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

How should PIOHOPE 15 MG TABLET be stored?

PIOHOPE 15 MG TABLET should be stored in a closed container at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep the tablets in their original container, protected from heat, moisture, and direct light. Ensure it is kept out of the reach of children.